BACKGROUND: Atherosclerotic remodeling starts early in life and can accelerate in the presence of cardiovascular risk (CV) factors. Regular physical activity (PA) can mitigate development of large and small artery disease during lifespan. We aimed to investigate the association of changes in body mass index (BMI), blood pressure (BP), PA behavior and retinal microvascular diameters with large artery pulse wave velocity (PWV) in prepubertal children over 4 years. METHODS: The school-based prospective cohort study included 262 children initially aged 6-8 years, assessing the above CV risk factors and retinal vessels by standardized procedures at baseline (2014) and follow-up (2018). PWV was assessed by an oscillometric device at follow-up. RESULTS: Children with increased systolic BP over 4 years showed higher PWV at follow-up (β [95% CI] 0.006 [0.002 to 0.011] mmHg per unit, P = 0.002). In contrast, increased vigorous PA corresponded to a lower PWV at follow-up (β [95% CI] -0.009 [-0.018 to <0-0.001] 10 min/day per unit, P = 0.047). Progression of retinal arteriolar narrowing and venular widening were linked to a higher PWV after 4 years (β [95% CI] -0.014 [-0.023 to -0.004] 0.01 changes per unit, P = 0.003). CONCLUSION: Increase in systolic BP and progression of microvascular dysfunction were associated with higher PWV after 4 years. Children with increasing levels of vigorous PA were found to have lower PWV at follow-up. Habitual vigorous PA has the potential to decelerate the process of early vascular aging in children and may thus help counteract CV disease development later in life. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, Identifier: NCT03085498.
BACKGROUND: Atherosclerotic remodeling starts early in life and can accelerate in the presence of cardiovascular risk (CV) factors. Regular physical activity (PA) can mitigate development of large and small artery disease during lifespan. We aimed to investigate the association of changes in body mass index (BMI), blood pressure (BP), PA behavior and retinal microvascular diameters with large artery pulse wave velocity (PWV) in prepubertal children over 4 years. METHODS: The school-based prospective cohort study included 262 children initially aged 6-8 years, assessing the above CV risk factors and retinal vessels by standardized procedures at baseline (2014) and follow-up (2018). PWV was assessed by an oscillometric device at follow-up. RESULTS: Children with increased systolic BP over 4 years showed higher PWV at follow-up (β [95% CI] 0.006 [0.002 to 0.011] mmHg per unit, P = 0.002). In contrast, increased vigorous PA corresponded to a lower PWV at follow-up (β [95% CI] -0.009 [-0.018 to <0-0.001] 10 min/day per unit, P = 0.047). Progression of retinal arteriolar narrowing and venular widening were linked to a higher PWV after 4 years (β [95% CI] -0.014 [-0.023 to -0.004] 0.01 changes per unit, P = 0.003). CONCLUSION: Increase in systolic BP and progression of microvascular dysfunction were associated with higher PWV after 4 years. Children with increasing levels of vigorous PA were found to have lower PWV at follow-up. Habitual vigorous PA has the potential to decelerate the process of early vascular aging in children and may thus help counteract CV disease development later in life. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, Identifier: NCT03085498.
Authors: Emanuela Falaschetti; Aroon D Hingorani; Alexander Jones; Marietta Charakida; Nicholas Finer; Peter Whincup; Debbie A Lawlor; George Davey Smith; Naveed Sattar; John E Deanfield Journal: Eur Heart J Date: 2010-10-23 Impact factor: 29.983
Authors: Scott A Lear; Weihong Hu; Sumathy Rangarajan; Danijela Gasevic; Darryl Leong; Romaina Iqbal; Amparo Casanova; Sumathi Swaminathan; R M Anjana; Rajesh Kumar; Annika Rosengren; Li Wei; Wang Yang; Wang Chuangshi; Liu Huaxing; Sanjeev Nair; Rafael Diaz; Hany Swidon; Rajeev Gupta; Noushin Mohammadifard; Patricio Lopez-Jaramillo; Aytekin Oguz; Katarzyna Zatonska; Pamela Seron; Alvaro Avezum; Paul Poirier; Koon Teo; Salim Yusuf Journal: Lancet Date: 2017-09-21 Impact factor: 79.321
Authors: Joseph T Flynn; David C Kaelber; Carissa M Baker-Smith; Douglas Blowey; Aaron E Carroll; Stephen R Daniels; Sarah D de Ferranti; Janis M Dionne; Bonita Falkner; Susan K Flinn; Samuel S Gidding; Celeste Goodwin; Michael G Leu; Makia E Powers; Corinna Rea; Joshua Samuels; Madeline Simasek; Vidhu V Thaker; Elaine M Urbina Journal: Pediatrics Date: 2017-08-21 Impact factor: 7.124
Authors: Roel J van de Laar; Isabel Ferreira; Willem van Mechelen; Martin H Prins; Jos W Twisk; Coen D Stehouwer Journal: Hypertension Date: 2009-12-07 Impact factor: 10.190
Authors: Yolandi Breet; Ashleigh Craig; Wayne Smith; Shani Botha-Le Roux; Lebo F Gafane-Matemane; Sanette Brits; Johannes M van Rooyen; Henner Hanssen; Ruan Kruger Journal: Front Pediatr Date: 2021-12-16 Impact factor: 3.418