AIMS: to examine the associations of several markers of adiposity and a wide range of cardiovascular risk factors and biomarkers in pre-pubertal children. METHODS AND RESULTS: four measures of adiposity,body mass index (BMI), waist circumference, dual-energy X-ray absorptiometry (DXA)-determined fat mass, and leptin concentration, were available in up to 7589 children aged 8.8-11.7 (9.9 mean) years from the Avon Longitudinal Study of Parents and Children (ALSPAC). Thirteen per cent of boys and 18.8% of girls were overweight, and 5.3% of boys and 5% of girls were obese. Body mass index was highly correlated with waist circumference (r = 0.91), DXA fat mass (r = 0.87), and leptin concentration (r = 0.75), and all had similar associations with cardiovascular risk factors. A 1 kg/m(2) greater BMI was associated with 1.4 mmHg (95% CI 1.25-1.44) higher systolic blood pressure (BP). In 5002 children, a 1 kg/m(2) greater BMI was associated with a 0.05 mmol/L (95% CI 0.036-0.055) higher non-high-density lipoprotein (HDL) cholesterol and 0.03 mmol/L (95% CI -0.034 to -0.025) lower HDL cholesterol. There were also graded associations with apolipoproteins A1 and B, interleukin-6, and C-reactive protein. Comparing children who were obese with those who were normal weight, the odds ratio for hypertension was 10.7 (95% CI 7.2-15.9) for boys and 13.5 (95% CI 9.4-19.5) for girls. CONCLUSION: in pre-pubertal UK children, overweight/obesity is common and has broadly similar associations with BP, HDL cholesterol, and non-HDL cholesterol to those observed in adults. Future research should evaluate whether effective interventions to maintain healthy weight in childhood could have important benefits for adult cardiovascular risk.
AIMS: to examine the associations of several markers of adiposity and a wide range of cardiovascular risk factors and biomarkers in pre-pubertal children. METHODS AND RESULTS: four measures of adiposity,body mass index (BMI), waist circumference, dual-energy X-ray absorptiometry (DXA)-determined fat mass, and leptin concentration, were available in up to 7589 children aged 8.8-11.7 (9.9 mean) years from the Avon Longitudinal Study of Parents and Children (ALSPAC). Thirteen per cent of boys and 18.8% of girls were overweight, and 5.3% of boys and 5% of girls were obese. Body mass index was highly correlated with waist circumference (r = 0.91), DXA fat mass (r = 0.87), and leptin concentration (r = 0.75), and all had similar associations with cardiovascular risk factors. A 1 kg/m(2) greater BMI was associated with 1.4 mmHg (95% CI 1.25-1.44) higher systolic blood pressure (BP). In 5002 children, a 1 kg/m(2) greater BMI was associated with a 0.05 mmol/L (95% CI 0.036-0.055) higher non-high-density lipoprotein (HDL) cholesterol and 0.03 mmol/L (95% CI -0.034 to -0.025) lower HDL cholesterol. There were also graded associations with apolipoproteins A1 and B, interleukin-6, and C-reactive protein. Comparing children who were obese with those who were normal weight, the odds ratio for hypertension was 10.7 (95% CI 7.2-15.9) for boys and 13.5 (95% CI 9.4-19.5) for girls. CONCLUSION: in pre-pubertal UK children, overweight/obesity is common and has broadly similar associations with BP, HDL cholesterol, and non-HDL cholesterol to those observed in adults. Future research should evaluate whether effective interventions to maintain healthy weight in childhood could have important benefits for adult cardiovascular risk.
Authors: S C Savva; M Tornaritis; M E Savva; Y Kourides; A Panagi; N Silikiotou; C Georgiou; A Kafatos Journal: Int J Obes Relat Metab Disord Date: 2000-11
Authors: Ranjana Sinha; Gene Fisch; Barbara Teague; William V Tamborlane; Bruna Banyas; Karin Allen; Mary Savoye; Vera Rieger; Sara Taksali; Gina Barbetta; Robert S Sherwin; Sonia Caprio Journal: N Engl J Med Date: 2002-03-14 Impact factor: 91.245
Authors: A Avenell; T J Brown; M A McGee; M K Campbell; A M Grant; J Broom; R T Jung; W C S Smith Journal: J Hum Nutr Diet Date: 2004-08 Impact factor: 3.089
Authors: Elsie M Taveras; Matthew W Gillman; Michelle-Marie Peña; Susan Redline; Sheryl L Rifas-Shiman Journal: Pediatrics Date: 2014-06 Impact factor: 7.124
Authors: Jane S Burns; Paige L Williams; Susan A Korrick; Russ Hauser; Oleg Sergeyev; Boris Revich; Thuy Lam; Mary M Lee Journal: Am J Epidemiol Date: 2014-09-25 Impact factor: 4.897
Authors: Andre Filipe Santos-Magalhaes; Luisa Aires; Clarice Martins; Gustavo Silva; Ana Maria Teixeira; Jorge Mota; Luis Rama Journal: Clin Auton Res Date: 2015-03-28 Impact factor: 4.435
Authors: L Toemen; O Gishti; S Vogelezang; R Gaillard; A Hofman; O H Franco; J F Felix; V W V Jaddoe Journal: Int J Obes (Lond) Date: 2015-04-29 Impact factor: 5.095
Authors: Laura D Howe; Kate Tilling; Li Benfield; Jennifer Logue; Naveed Sattar; Andy R Ness; George Davey Smith; Debbie A Lawlor Journal: PLoS One Date: 2010-12-08 Impact factor: 3.240