Literature DB >> 33381480

Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation.

Mira N Moufarrej1, Ronald J Wong2, Gary M Shaw2, David K Stevenson2, Stephen R Quake1.   

Abstract

In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.
Copyright © 2020 Moufarrej, Wong, Shaw, Stevenson and Quake.

Entities:  

Keywords:  IUGR; cell-free RNA; prediction; preeclampsia; preterm birth; transcriptome

Year:  2020        PMID： 33381480      PMCID： PMC7767905          DOI： 10.3389/fped.2020.605219

Source DB:  PubMed          Journal:  Front Pediatr        ISSN： 2296-2360            Impact factor:   3.418


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