| Literature DB >> 33275656 |
Jacob Stauber1, John M Greally1, Ulrich Steidl1.
Abstract
Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and relapse. We highlight recent advances and unanswered questions about the contribution of the hematopoietic stem cell population to these processes.Entities:
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Year: 2021 PMID: 33275656 PMCID: PMC7907728 DOI: 10.1182/blood.2019004397
Source DB: PubMed Journal: Blood ISSN: 0006-4971 Impact factor: 22.113