Literature DB >> 30104218

Chronic immune response dysregulation in MDS pathogenesis.

Laura Barreyro1, Timothy M Chlon1,2, Daniel T Starczynowski1,2.   

Abstract

Chronic innate immune signaling in hematopoietic cells is widely described in myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly via pattern recognition receptors, increases the risk of developing MDS. An inflammatory component to MDS has been reported for many years, but only recently has evidence supported a more direct role of chronic innate immune signaling and associated inflammatory pathways in the pathogenesis of MDS. Here we review recent findings and discuss relevant questions related to chronic immune response dysregulation in MDS.
© 2018 by The American Society of Hematology.

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Year:  2018        PMID： 30104218      PMCID： PMC6182269          DOI： 10.1182/blood-2018-03-784116

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  112 in total

1.  The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate.

Authors:  K De Luca; V Frances-Duvert; M-J Asensio; R Ihsani; E Debien; M Taillardet; E Verhoeyen; C Bella; S Lantheaume; L Genestier; T Defrance
Journal:  Leukemia       Date:  2009-07-30       Impact factor: 11.528

2.  Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia.

Authors:  Steven M Kornblau; David McCue; Neera Singh; Wenjing Chen; Zeev Estrov; Kevin R Coombes
Journal:  Blood       Date:  2010-08-02       Impact factor: 22.113

3.  Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs.

Authors:  Claudia Benz; Michael R Copley; David G Kent; Stefan Wohrer; Adrian Cortes; Nima Aghaeepour; Elaine Ma; Heidi Mader; Keegan Rowe; Christopher Day; David Treloar; Ryan R Brinkman; Connie J Eaves
Journal:  Cell Stem Cell       Date:  2012-03-02       Impact factor: 24.633

Review 4.  Deconstructing innate immune signaling in myelodysplastic syndromes.

Authors:  Madeline Niederkorn; Molly Smith; Laura Barreyro; Melinda E Varney; Katelyn Melgar; Daniel T Starczynowski
Journal:  Exp Hematol       Date:  2015-07-02       Impact factor: 3.084

5.  Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.

Authors:  Shuai Chen; Chunjie Sheng; Dong Liu; Chen Yao; Shijuan Gao; Liping Song; Wei Jiang; Jiandong Li; Wenlin Huang
Journal:  J Immunol       Date:  2013-08-05       Impact factor: 5.422

6.  Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS.

Authors:  Ganesan Keerthivasan; Yang Mei; Baobing Zhao; Ling Zhang; Chad E Harris; Juehua Gao; Ashley A Basiorka; Matthew J Schipma; James McElherne; Jing Yang; Amit K Verma; Andrea Pellagatti; Jacqueline Boultwood; Alan F List; David A Williams; Peng Ji
Journal:  Blood       Date:  2014-06-02       Impact factor: 22.113

7.  Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.

Authors:  Xiaowei Chen; Huan Deng; Michael J Churchill; Larry L Luchsinger; Xing Du; Timothy H Chu; Richard A Friedman; Moritz Middelhoff; Hongxu Ding; Yagnesh H Tailor; Alexander L E Wang; Haibo Liu; Zhengchuan Niu; Hongshan Wang; Zhengyu Jiang; Simon Renders; Siu-Hong Ho; Spandan V Shah; Pavel Tishchenko; Wenju Chang; Theresa C Swayne; Laura Munteanu; Andrea Califano; Ryota Takahashi; Karan K Nagar; Bernhard W Renz; Daniel L Worthley; C Benedikt Westphalen; Yoku Hayakawa; Samuel Asfaha; Florence Borot; Chyuan-Sheng Lin; Hans-Willem Snoeck; Siddhartha Mukherjee; Timothy C Wang
Journal:  Cell Stem Cell       Date:  2017-11-30       Impact factor: 24.633

8.  STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.

Authors:  Huiyuan Zhang; Hongbo Hu; Nathaniel Greeley; Jin Jin; Allison J Matthews; Erika Ohashi; Mauricio S Caetano; Haiyan S Li; Xuefeng Wu; Pijus K Mandal; John S McMurray; Seyed Javad Moghaddam; Shao-Cong Sun; Stephanie S Watowich
Journal:  Nat Commun       Date:  2014-12-15       Impact factor: 14.919

9.  Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome.

Authors:  Astrid Olsnes Kittang; Shahram Kordasti; Kristoffer Evebø Sand; Benedetta Costantini; Anne Marijn Kramer; Pilar Perezabellan; Thomas Seidl; Kristin Paulsen Rye; Karen Marie Hagen; Austin Kulasekararaj; Øystein Bruserud; Ghulam J Mufti
Journal:  Oncoimmunology       Date:  2015-06-24       Impact factor: 8.110

10.  Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.

Authors:  Shixin Ma; Xiaoling Wan; Zihou Deng; Lei Shi; Congfang Hao; Zhenyuan Zhou; Chun Zhou; Yiyuan Fang; Jinghua Liu; Jing Yang; Xia Chen; Tiantian Li; Aiping Zang; Shigang Yin; Bin Li; Joel Plumas; Laurence Chaperot; Xiaoming Zhang; Guoliang Xu; Lubin Jiang; Nan Shen; Sidong Xiong; Xiaoming Gao; Yan Zhang; Hui Xiao
Journal:  J Exp Med       Date:  2017-04-17       Impact factor: 14.307
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  57 in total

Review 1.  The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes.

Authors:  David A Sallman; Alan List
Journal:  Blood       Date:  2019-01-22       Impact factor: 22.113

2.  Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.

Authors:  Jian Zhang; Abdullah M Ali; Yen K Lieu; Zhaoqi Liu; Jianchao Gao; Raul Rabadan; Azra Raza; Siddhartha Mukherjee; James L Manley
Journal:  Mol Cell       Date:  2019-08-29       Impact factor: 17.970

3.  Ubiquitination is not omnipresent in myeloid leukemia.

Authors:  Ramesh C Nayak; Jose A Cancelas
Journal:  Haematologica       Date:  2019-09       Impact factor: 9.941

4.  Immune Dysregulation and Recurring Mutations in Myelodysplastic Syndromes Pathogenesis.

Authors:  Anacélia Matos; Silvia M M Magalhães; Michael J Rauh
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.

Authors:  Roberta Taiane Germano de Oliveira; João Victor Alves Cordeiro; Bruna Ferreira Vitoriano; Mayara Magna de Lima Melo; Letícia Rodrigues Sampaio; Daniela de Paula Borges; Silvia Maria Meira Magalhães; Ronald Feitosa Pinheiro
Journal:  Med Oncol       Date:  2021-02-17       Impact factor: 3.064

Review 6.  Canonical Wnt: a safeguard and threat for erythropoiesis.

Authors:  Rosa A Krimpenfort; Micha Nethe
Journal:  Blood Adv       Date:  2021-09-28

7.  Immune-Based Therapeutic Interventions for Acute Myeloid Leukemia.

Authors:  Fabiana Perna; Manuel R Espinoza-Gutarra; Giuseppe Bombaci; Sherif S Farag; Jennifer E Schwartz
Journal:  Cancer Treat Res       Date:  2022

Review 8.  Environmental influences on clonal hematopoiesis.

Authors:  Katherine Y King; Yun Huang; Daisuke Nakada; Margaret A Goodell
Journal:  Exp Hematol       Date:  2019-12-29       Impact factor: 3.084

9.  Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.

Authors:  Tomoya Muto; Callum S Walker; Kwangmin Choi; Kathleen Hueneman; Molly A Smith; Zartash Gul; Guillermo Garcia-Manero; Averil Ma; Yi Zheng; Daniel T Starczynowski
Journal:  Nat Immunol       Date:  2020-04-20       Impact factor: 25.606

Review 10.  Preleukemic and leukemic evolution at the stem cell level.

Authors:  Jacob Stauber; John M Greally; Ulrich Steidl
Journal:  Blood       Date:  2021-02-25       Impact factor: 22.113
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