Zeb D Jonker1, Carolin Gaiser2, Joke H M Tulen3, Gerard M Ribbers4, Maarten A Frens2, Ruud W Selles5. 1. Department of Neuroscience, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Rehabilitation Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Rijndam Rehabilitation Center, Rotterdam, the Netherlands. 2. Department of Neuroscience, Erasmus University Medical Center, Rotterdam, the Netherlands. 3. Department of Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands. 4. Department of Rehabilitation Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Rijndam Rehabilitation Center, Rotterdam, the Netherlands. 5. Department of Rehabilitation Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Plastic and Reconstructive Surgery, Erasmus University Medical Centre, Rotterdam, the Netherlands. Electronic address: r.selles@erasmusmc.nl.
Abstract
BACKGROUND:Transcranial direct current stimulation (tDCS) has emerged as a non-invasive brain stimulation technique. Most studies show that anodal tDCS increases cortical excitability. However, this effect has been found to be highly variable. OBJECTIVE: To test the effect of anodal tDCS on cortical excitability and the interaction effect of two participant-specific factors that may explain individual differences in sensitivity to anodal tDCS: the Brain Derived Neurotrophic Factor Val66Met polymorphism (BDNF genotype) and the latency difference between anterior-posterior and lateromedial TMS pulses (APLM latency). METHODS: In 62 healthy participants, cortical excitability over the left motor cortex was measured before and after anodal tDCS at 2 mA for 20 min in a pre-registered, double-blind, randomized, placebo-controlled trial with repeated measures. RESULTS: We did not find a main effect of anodal tDCS, nor an interaction effect of the participant-specific predictors. Moreover, further analyses did not provide evidence for the existence of responders and non-responders. CONCLUSION: This study indicates that anodal tDCS at 2 mA for 20 min may not reliably affect cortical excitability.
RCT Entities:
BACKGROUND: Transcranial direct current stimulation (tDCS) has emerged as a non-invasive brain stimulation technique. Most studies show that anodal tDCS increases cortical excitability. However, this effect has been found to be highly variable. OBJECTIVE: To test the effect of anodal tDCS on cortical excitability and the interaction effect of two participant-specific factors that may explain individual differences in sensitivity to anodal tDCS: the Brain Derived Neurotrophic Factor Val66Met polymorphism (BDNF genotype) and the latency difference between anterior-posterior and lateromedial TMS pulses (APLM latency). METHODS: In 62 healthy participants, cortical excitability over the left motor cortex was measured before and after anodal tDCS at 2 mA for 20 min in a pre-registered, double-blind, randomized, placebo-controlled trial with repeated measures. RESULTS: We did not find a main effect of anodal tDCS, nor an interaction effect of the participant-specific predictors. Moreover, further analyses did not provide evidence for the existence of responders and non-responders. CONCLUSION: This study indicates that anodal tDCS at 2 mA for 20 min may not reliably affect cortical excitability.
Authors: Marie Louise Liu; Anke Ninija Karabanov; Marjolein Piek; Esben Thade Petersen; Axel Thielscher; Hartwig Roman Siebner Journal: Sci Rep Date: 2022-06-10 Impact factor: 4.996
Authors: Joris Van der Cruijsen; Zeb D Jonker; Eleni-Rosalina Andrinopoulou; Jessica E Wijngaarden; Ditte A Tangkau; Joke H M Tulen; Maarten A Frens; Gerard M Ribbers; Ruud W Selles Journal: Front Hum Neurosci Date: 2022-05-04 Impact factor: 3.473
Authors: Timothy R Macaulay; Brian T Peters; Scott J Wood; Gilles R Clément; Lars Oddsson; Jacob J Bloomberg Journal: Front Syst Neurosci Date: 2021-04-27