Jutta Joormann1, Samuel A McLean2,3, Francesca L Beaudoin4,5,6,7, Xinming An2, Jennifer S Stevens8, Donglin Zeng9, Thomas C Neylan10,11, Gari Clifford12, Sarah D Linnstaedt2, Laura T Germine13,14,15, Scott L Rauch16, Paul I Musey17, Phyllis L Hendry18, Sophia Sheikh18, Christopher W Jones19, Brittany E Punches20,21, Gregory Fermann20, Lauren A Hudak22, Kamran Mohiuddin23, Vishnu Murty24, Meghan E McGrath25, John P Haran26, Jose Pascual27, Mark Seamon28, David A Peak29, Claire Pearson30, Robert M Domeier31, Paulina Sergot32, Roland Merchant33, Leon D Sanchez34,35, Niels K Rathlev36, William F Peacock37, Steven E Bruce38, Deanna Barch39, Diego A Pizzagalli14, Beatriz Luna40, Steven E Harte41, Irving Hwang42, Sue Lee42, Nancy Sampson42, Karestan C Koenen43, Kerry J Ressler14,44, Ronald C Kessler42,44. 1. Department of Psychology, Yale University, New Haven, CT, USA. 2. Department of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 3. Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 4. Department of Emergency Medicine, The Alpert Medical School of Brown University, Providence, RI, USA. 5. Department of Health Services, Policy and Practice, Brown University School of Public Health, Providence, RI, USA. 6. Rhode Island Hospital, Providence, RI, USA. 7. The Miriam Hospital, Providence, RI, USA. 8. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. 9. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. 10. San Francisco VA Healthcare System, San Francisco, CA, USA. 11. Departments of Psychiatry and Neurology, University of California, San Francisco, CA, USA. 12. Department of Biomedical Informatics, Emory University School of Medicine and Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. 13. Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA. 14. Department of Psychiatry, Harvard Medical School, Boston, MA, USA. 15. The Many Brains Project, Acton, MA, USA. 16. Department of Psychiatry, McLean Hospital, Belmont, MA, USA. 17. Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. 18. Department of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA. 19. Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA. 20. Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. 21. University of Cincinnati College of Nursing, Cincinnati, OH, USA. 22. Department of Emergency Medicine, Emory University, Grady Memorial Hospital, Atlanta, GA, USA. 23. Department of Emergency Medicine/Internal Medicine, Einstein Medical Center, Philadelphia, PA, USA. 24. Department of Psychology, Temple University, Philadelphia, PA, USA. 25. Departmentof Emergency Medicine, Boston Medical Center, Boston, MA, USA. 26. Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA. 27. Department of Surgery and Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. 28. Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA. 29. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA. 30. Wayne State University Department of Emergency Medicine, Ascension St. John Hospital, Detroit, MI, USA. 31. Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ann Arbor, MI, USA. 32. Department of Emergency Medicine, University of Texas Health Science Center, Houston, TX, USA. 33. Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA. 34. Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. 35. Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA. 36. Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA. 37. Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA. 38. Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA. 39. Departments of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University in St. Louis, St. Louis, MO, USA. 40. Laboratory of Neurocognitive Development, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 41. Departments of Anesthesiology and Internal Medicine-Rheumatology, Chronic Pain and Fatigue Research Center, University of Michigan Medical School, Ann Arbor, MI, USA. 42. Department of Health Care Policy, Harvard Medical School, Boston, MA, USA. 43. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. 44. Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Abstract
BACKGROUND: This is the first report on the association between trauma exposure and depression from the Advancing Understanding of RecOvery afteR traumA(AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. METHODS: We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression. RESULTS: Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma. CONCLUSIONS: These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.
BACKGROUND: This is the first report on the association between trauma exposure and depression from the Advancing Understanding of RecOvery afteR traumA(AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. METHODS: We focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression. RESULTS: Eight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma. CONCLUSIONS: These observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.
Authors: K C Koenen; A Ratanatharathorn; L Ng; K A McLaughlin; E J Bromet; D J Stein; E G Karam; A Meron Ruscio; C Benjet; K Scott; L Atwoli; M Petukhova; C C W Lim; S Aguilar-Gaxiola; A Al-Hamzawi; J Alonso; B Bunting; M Ciutan; G de Girolamo; L Degenhardt; O Gureje; J M Haro; Y Huang; N Kawakami; S Lee; F Navarro-Mateu; B-E Pennell; M Piazza; N Sampson; M Ten Have; Y Torres; M C Viana; D Williams; M Xavier; R C Kessler Journal: Psychol Med Date: 2017-04-07 Impact factor: 7.723
Authors: Jutta Joormann; Hannah N Ziobrowski; Andrew J King; Sarah M Gildea; Sue Lee; Nancy A Sampson; Stacey L House; Francesca L Beaudoin; Xinming An; Jennifer S Stevens; Donglin Zeng; Thomas C Neylan; Gari D Clifford; Sarah D Linnstaedt; Laura T Germine; Kenneth A Bollen; Scott L Rauch; John P Haran; Alan B Storrow; Paul I Musey; Phyllis L Hendry; Sophia Sheikh; Christopher W Jones; Brittany E Punches; Meghan E McGrath; Lauren A Hudak; Jose L Pascual; Mark J Seamon; Anna M Chang; Claire Pearson; David A Peak; Robert M Domeier; Niels K Rathlev; Brian J O'Neil; Leon D Sanchez; Steven E Bruce; Mark W Miller; Robert H Pietrzak; Deanna M Barch; Diego A Pizzagalli; Steven E Harte; James M Elliott; Karestan C Koenen; Samuel A McLean; Ronald C Kessler Journal: Depress Anxiety Date: 2021-11-15 Impact factor: 6.505
Authors: N G Harnett; N M Dumornay; M Delity; L D Sanchez; K Mohiuddin; P I Musey; M J Seamon; S A McLean; R C Kessler; K C Koenen; F L Beaudoin; L A M Lebois; S J H van Rooij; N A Sampson; V Michopoulos; J L Maples-Keller; J P Haran; A B Storrow; C Lewandowski; P L Hendry; S Sheikh; C W Jones; B E Punches; M C Kurz; R A Swor; M E McGrath; L A Hudak; J L Pascual; S L House; X An; J S Stevens; T C Neylan; T Jovanovic; S D Linnstaedt; L T Germine; E M Datner; A M Chang; C Pearson; D A Peak; R C Merchant; R M Domeier; N K Rathlev; B J O'Neil; P Sergot; S E Bruce; M W Miller; R H Pietrzak; J Joormann; D M Barch; D A Pizzagalli; J F Sheridan; J W Smoller; B Luna; S E Harte; J M Elliott; K J Ressler Journal: Psychol Med Date: 2022-01-31 Impact factor: 10.592
Authors: Jennifer S Stevens; Nathaniel G Harnett; Lauren A M Lebois; Sanne J H van Rooij; Timothy D Ely; Alyssa Roeckner; Nico Vincent; Francesca L Beaudoin; Xinming An; Donglin Zeng; Thomas C Neylan; Gari D Clifford; Sarah D Linnstaedt; Laura T Germine; Scott L Rauch; Christopher Lewandowski; Alan B Storrow; Phyllis L Hendry; Sophia Sheikh; Paul I Musey; John P Haran; Christopher W Jones; Brittany E Punches; Michael S Lyons; Michael C Kurz; Meghan E McGrath; Jose L Pascual; Elizabeth M Datner; Anna M Chang; Claire Pearson; David A Peak; Robert M Domeier; Brian J O'Neil; Niels K Rathlev; Leon D Sanchez; Robert H Pietrzak; Jutta Joormann; Deanna M Barch; Diego A Pizzagalli; John F Sheridan; Beatriz Luna; Steven E Harte; James M Elliott; Vishnu P Murty; Tanja Jovanovic; Steven E Bruce; Stacey L House; Ronald C Kessler; Karestan C Koenen; Samuel A McLean; Kerry J Ressler Journal: Am J Psychiatry Date: 2021-10-14 Impact factor: 19.242
Authors: Thomas C Neylan; Ronald C Kessler; Kerry J Ressler; Gari Clifford; Francesca L Beaudoin; Xinming An; Jennifer S Stevens; Donglin Zeng; Sarah D Linnstaedt; Laura T Germine; Sophia Sheikh; Alan B Storrow; Brittany E Punches; Kamran Mohiuddin; Nina T Gentile; Meghan E McGrath; Sanne J H van Rooij; John P Haran; David A Peak; Robert M Domeier; Claire Pearson; Leon D Sanchez; Niels K Rathlev; William F Peacock; Steven E Bruce; Jutta Joormann; Deanna M Barch; Diego A Pizzagalli; John F Sheridan; Steven E Harte; James M Elliott; Irving Hwang; Maria V Petukhova; Nancy A Sampson; Karestan C Koenen; Samuel A McLean Journal: Sleep Date: 2021-03-12 Impact factor: 5.849
Authors: Antoine Yrondi; Hélène Colineaux; Isabelle Claudet; Jérome Sales de Gauzy; Samantha Huo; Simon Taib; Eric Bui; Philippe Birmes Journal: Eur J Psychotraumatol Date: 2022-09-27
Authors: Jarred J Lobo; Samuel A McLean; Andrew S Tungate; David A Peak; Robert A Swor; Niels K Rathlev; Phyllis L Hendry; Sarah D Linnstaedt Journal: Transl Psychiatry Date: 2021-06-29 Impact factor: 6.222