Jutta Joormann1, Hannah N Ziobrowski2, Andrew J King2, Sarah M Gildea2, Sue Lee2, Nancy A Sampson2, Stacey L House3, Francesca L Beaudoin4,5,6,7, Xinming An8, Jennifer S Stevens9, Donglin Zeng10, Thomas C Neylan11,12, Gari D Clifford13,14, Sarah D Linnstaedt8, Laura T Germine15,16,17, Kenneth A Bollen18,19,20, Scott L Rauch16,18,21, John P Haran22, Alan B Storrow23, Paul I Musey24, Phyllis L Hendry25, Sophia Sheikh25, Christopher W Jones26, Brittany E Punches27,28, Meghan E McGrath29, Lauren A Hudak30, Jose L Pascual31,32,33, Mark J Seamon33,34, Anna M Chang35, Claire Pearson36, David A Peak37, Robert M Domeier38, Niels K Rathlev39, Brian J O'Neil36, Leon D Sanchez40,41, Steven E Bruce42, Mark W Miller43,44, Robert H Pietrzak45,46, Deanna M Barch47, Diego A Pizzagalli18,48, Steven E Harte49,50, James M Elliott51,52,53,54, Karestan C Koenen55, Samuel A McLean8,56, Ronald C Kessler2. 1. Department of Psychology, Yale University, New Haven, Connecticut, USA. 2. Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA. 3. Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. 4. Department of Emergency Medicine, The Alpert Medical School of Brown University, Providence, Rhode Island, USA. 5. Department of Health Services, Policy, and Practice, The Alpert Medical School of Brown University, Providence, Rhode Island, USA. 6. Department of Emergency Medicine, Rhode Island Hospital, Providence, Rhode Island, USA. 7. Department of Emergency Medicine, The Miriam Hospital, Providence, Rhode Island, USA. 8. Department of Anesthesiology, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 9. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA. 10. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA. 11. Department of Psychiatry, University of California San Francisco, San Francisco, California, USA. 12. Department of Neurology, University of California San Francisco, San Francisco, California, USA. 13. Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA. 14. Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. 15. Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA. 16. Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts, USA. 17. The Many Brains Project, Inc., Belmont, Massachusetts, USA. 18. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. 19. Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 20. Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 21. Department of Psychiatry, McLean Hospital, Belmont, Massachusetts, USA. 22. Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 23. Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 24. Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. 25. Department of Emergency Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA. 26. Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey, USA. 27. Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. 28. College of Nursing, University of Cincinnati, Cincinnati, Ohio, USA. 29. Department of Emergency Medicine, Boston Medical Center, Boston, Massachusetts, USA. 30. Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. 31. Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 32. Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 33. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 34. Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 35. Department of Emergency Medicine, Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. 36. Department of Emergency Medicine, Wayne State University, Detroit, Massachusetts, USA. 37. Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. 38. Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, Michigan, USA. 39. Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts, USA. 40. Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. 41. Department of Emergency Medicine, Harvard Medical School, Boston, Massachusetts, USA. 42. Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, Missouri, USA. 43. Behavioral Science Division, National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts, USA. 44. Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA. 45. Clinical Neurosciences Division, National Center for PTSD, VA Connecticut Healthcare System, West Haven, Connecticut, USA. 46. Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA. 47. Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA. 48. Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts, USA. 49. Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA. 50. Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. 51. Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia. 52. Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. 53. Allied Health Network, Northern Sydney Local Health District, Sydney, New South Wales, Australia. 54. Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. 55. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA. 56. Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Abstract
BACKGROUND: A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions. METHODS: Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders. RESULTS: 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6-7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders. CONCLUSIONS: Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.
BACKGROUND: A better understanding of the extent to which prior occurrences of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) predict psychopathological reactions to subsequent traumas might be useful in targeting posttraumatic preventive interventions. METHODS: Data come from 1306 patients presenting to 29 U.S. emergency departments (EDs) after a motor vehicle collision (MVC) in the advancing understanding of recovery after trauma study. Patients completed self-reports in the ED and 2-weeks, 8-weeks, and 3-months post-MVC. Associations of pre-MVC probable PTSD and probable MDE histories with subsequent 3-months post-MVC probable PTSD and probable MDE were examined along with mediation through intervening peritraumatic, 2-, and 8-week disorders. RESULTS: 27.6% of patients had 3-month post-MVC probable PTSD and/or MDE. Pre-MVC lifetime histories of these disorders were not only significant (relative risk = 2.6-7.4) but were dominant (63.1% population attributable risk proportion [PARP]) predictors of this 3-month outcome, with 46.6% prevalence of the outcome among patients with pre-MVC disorder histories versus 9.9% among those without such histories. The associations of pre-MVC lifetime disorders with the 3-month outcome were mediated largely by 2- and 8-week probable PTSD and MDE (PARP decreasing to 22.8% with controls for these intervening disorders). Decomposition showed that pre-MVC lifetime histories predicted both onset and persistence of these intervening disorders as well as the higher conditional prevalence of the 3-month outcome in the presence of these intervening disorders. CONCLUSIONS: Assessments of pre-MVC PTSD and MDE histories and follow-ups at 2 and 8 weeks could help target early interventions for psychopathological reactions to MVCs.
Authors: Sarah R Lowe; Andrew Ratanatharathorn; Betty S Lai; Willem van der Mei; Anna C Barbano; Richard A Bryant; Douglas L Delahanty; Yutaka J Matsuoka; Miranda Olff; Ulrich Schnyder; Eugene Laska; Karestan C Koenen; Arieh Y Shalev; Ronald C Kessler Journal: Psychol Med Date: 2020-02-03 Impact factor: 7.723
Authors: Matthew Price; Katherine van Stolk-Cooke; Hannah L Ward; Michael O'Keefe; Jennifer Gratton; Christian Skalka; Kalev Freeman Journal: J Technol Behav Sci Date: 2017-01-11
Authors: K C Koenen; A Ratanatharathorn; L Ng; K A McLaughlin; E J Bromet; D J Stein; E G Karam; A Meron Ruscio; C Benjet; K Scott; L Atwoli; M Petukhova; C C W Lim; S Aguilar-Gaxiola; A Al-Hamzawi; J Alonso; B Bunting; M Ciutan; G de Girolamo; L Degenhardt; O Gureje; J M Haro; Y Huang; N Kawakami; S Lee; F Navarro-Mateu; B-E Pennell; M Piazza; N Sampson; M Ten Have; Y Torres; M C Viana; D Williams; M Xavier; R C Kessler Journal: Psychol Med Date: 2017-04-07 Impact factor: 7.723
Authors: Richard A Bryant; Lisa Gibbs; H Colin Gallagher; Phillipa Pattison; Dean Lusher; Colin MacDougall; Louise Harms; Karen Block; Greg Ireton; John Richardson; David Forbes; Robyn Molyneaux; Meaghan O'Donnell Journal: Aust N Z J Psychiatry Date: 2020-11-11 Impact factor: 5.744
Authors: Madelon B Bronner; Anne-Marie Kayser; Hendrika Knoester; Albert P Bos; Bob F Last; Martha A Grootenhuis Journal: Child Adolesc Psychiatry Ment Health Date: 2009-10-15 Impact factor: 3.033