Jennifer S Stevens1, Nathaniel G Harnett1, Lauren A M Lebois1, Sanne J H van Rooij1, Timothy D Ely1, Alyssa Roeckner1, Nico Vincent1, Francesca L Beaudoin1, Xinming An1, Donglin Zeng1, Thomas C Neylan1, Gari D Clifford1, Sarah D Linnstaedt1, Laura T Germine1, Scott L Rauch1, Christopher Lewandowski1, Alan B Storrow1, Phyllis L Hendry1, Sophia Sheikh1, Paul I Musey1, John P Haran1, Christopher W Jones1, Brittany E Punches1, Michael S Lyons1, Michael C Kurz1, Meghan E McGrath1, Jose L Pascual1, Elizabeth M Datner1, Anna M Chang1, Claire Pearson1, David A Peak1, Robert M Domeier1, Brian J O'Neil1, Niels K Rathlev1, Leon D Sanchez1, Robert H Pietrzak1, Jutta Joormann1, Deanna M Barch1, Diego A Pizzagalli1, John F Sheridan1, Beatriz Luna1, Steven E Harte1, James M Elliott1, Vishnu P Murty1, Tanja Jovanovic1, Steven E Bruce1, Stacey L House1, Ronald C Kessler1, Karestan C Koenen1, Samuel A McLean1, Kerry J Ressler1. 1. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta (Stevens, van Rooij, Ely, Roeckner, Vincent); Division of Depression and Anxiety, McLean Hospital, Belmont, Mass. (Harnett, Lebois, Ressler); Department of Psychiatry, Harvard Medical School, Boston (Harnett, Lebois, Pizzagalli, Ressler); Departments of Emergency Medicine and Health Services, Policy, and Practice, Alpert Medical School of Brown University, Rhode Island Hospital, and the Miriam Hospital, Providence, R.I. (Beaudoin); Department of Anesthesiology, Institute of Trauma Recovery, University of North Carolina, Chapel Hill (An, Linnstaedt, McLean); Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (Zeng); Departments of Psychiatry and Neurology, University of California, San Francisco (Neylan); Department of Biomedical Informatics, Emory University School of Medicine, Atlanta (Clifford); Institute for Technology in Psychiatry (Germine) and Department of Psychiatry (Rauch), McLean Hospital, Belmont, Mass.; Department of Emergency Medicine, Henry Ford Health System, Detroit (Lewandowski); Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tenn. (Storrow); Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville (Hendry, Sheikh); Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis (Musey); Department of Emergency Medicine, University of Massachusetts Medical School, Worcester (Haran); Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, N.J. (Jones); Department of Emergency Medicine, College of Medicine and College of Nursing, University of Cincinnati, Cincinnati (Punches); Department of Emergency Medicine and Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati (Lyons); Departments of Emergency Medicine and Surgery, Division of Acute Care Surgery, University of Alabama School of Medicine, Birmingham (Kurz); Center for Injury Science, University of Alabama, Birmingham (Kurz); Department of Emergency Medicine, Boston Medical Center, Boston (McGrath); Departments of Surgery (Pascual) and Neurosurgery (Pascual), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Emergency Medicine, Einstein Health Care Network, Philadelphia (Datner); Department of Emergency Medicine, Jefferson University Hospitals, Philadelphia (Chang); Department of Emergency Medicine, Wayne State University, Detroit (Pearson); Department of Emergency Medicine, Massachusetts General Hospital, Boston (Peak); Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ann Arbor, Mich. (Domeier); Department of Emergency Medicine, Wayne State University School of Medicine, Detroit (O'Neil); Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield (Rathley); Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston (Sanchez); Department of Emergency Medicine, Harvard Medical School, Boston (Sanchez); Department of Psychiatry, Yale School of Medicine, and U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, New Haven, Conn. (Pietrzak); Department of Psychology, Yale University, New Haven, Conn. (Joorman); Department of Psychological and Brain Sciences, Washington University, St. Louis (Barch); Department of Biosciences and Neuroscience and Institute for Behavioral Medicine Research, Ohio State University Wexner Medical Center, Columbus (Sheridan); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Luna); Departments of Anesthesiology and Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor (Harte); the Kolling Institute of Medical Research, Northern Clinical School, University of Sydney, and Faculty of Medicine and Health, University of Sydney, Sydney, Australia (Elliott); Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago (Elliott); Department of Psychology, Temple University, Philadelphia (Murty); Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit (Jovanovich); Department of Psychological Sciences, University of Missouri, St. Louis (Bruce); Department of Emergency Medicine, Washington University School of Medicine, St. Louis (House); Department of Health Care Policy, Harvard Medical School, Boston (Kessler); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Koenen); Department of Emergency Medicine, University of North Carolina, Chapel Hill (McLean).
Abstract
OBJECTIVE: Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations. METHODS: A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments. RESULTS: Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms. CONCLUSIONS: These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.
OBJECTIVE: Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations. METHODS: A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments. RESULTS: Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms. CONCLUSIONS: These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.
Authors: Andrew T Drysdale; Logan Grosenick; Jonathan Downar; Katharine Dunlop; Farrokh Mansouri; Yue Meng; Robert N Fetcho; Benjamin Zebley; Desmond J Oathes; Amit Etkin; Alan F Schatzberg; Keith Sudheimer; Jennifer Keller; Helen S Mayberg; Faith M Gunning; George S Alexopoulos; Michael D Fox; Alvaro Pascual-Leone; Henning U Voss; B J Casey; Marc J Dubin; Conor Liston Journal: Nat Med Date: 2016-12-05 Impact factor: 53.440
Authors: Lisa S Talbot; Shira Maguen; Thomas J Metzler; Martha Schmitz; Shannon E McCaslin; Anne Richards; Michael L Perlis; Donn A Posner; Brandon Weiss; Leslie Ruoff; Jonathan Varbel; Thomas C Neylan Journal: Sleep Date: 2014-02-01 Impact factor: 5.849
Authors: Sanne J H van Rooij; Meghna Ravi; Timothy D Ely; Vasiliki Michopoulos; Sterling J Winters; Jaemin Shin; Marie-France Marin; Mohammed R Milad; Barbara O Rothbaum; Kerry J Ressler; Tanja Jovanovic; Jennifer S Stevens Journal: Behav Brain Res Date: 2021-04-02 Impact factor: 3.352
Authors: Richard Dinga; Lianne Schmaal; Brenda W J H Penninx; Marie Jose van Tol; Dick J Veltman; Laura van Velzen; Maarten Mennes; Nic J A van der Wee; Andre F Marquand Journal: Neuroimage Clin Date: 2019-03-27 Impact factor: 4.881
Authors: Samuel A McLean; Kerry Ressler; Karestan Chase Koenen; Thomas Neylan; Laura Germine; Tanja Jovanovic; Gari D Clifford; Donglin Zeng; Xinming An; Sarah Linnstaedt; Francesca Beaudoin; Stacey House; Kenneth A Bollen; Paul Musey; Phyllis Hendry; Christopher W Jones; Christopher Lewandowski; Robert Swor; Elizabeth Datner; Kamran Mohiuddin; Jennifer S Stevens; Alan Storrow; Michael Christopher Kurz; Meghan E McGrath; Gregory J Fermann; Lauren A Hudak; Nina Gentile; Anna Marie Chang; David A Peak; Jose L Pascual; Mark J Seamon; Paulina Sergot; W Frank Peacock; Deborah Diercks; Leon D Sanchez; Niels Rathlev; Robert Domeier; John Patrick Haran; Claire Pearson; Vishnu P Murty; Thomas R Insel; Paul Dagum; Jukka-Pekka Onnela; Steven E Bruce; Bradley N Gaynes; Jutta Joormann; Mark W Miller; Robert H Pietrzak; Daniel J Buysse; Diego A Pizzagalli; Scott L Rauch; Steven E Harte; Larry J Young; Deanna M Barch; Lauren A M Lebois; Sanne J H van Rooij; Beatriz Luna; Jordan W Smoller; Robert F Dougherty; Thaddeus W W Pace; Elisabeth Binder; John F Sheridan; James M Elliott; Archana Basu; Menachem Fromer; Tushar Parlikar; Alan M Zaslavsky; Ronald Kessler Journal: Mol Psychiatry Date: 2019-11-19 Impact factor: 15.992
Authors: Abigail Powers; Cecilia A Hinojosa; Jennifer S Stevens; Brandon Harvey; Pascal Pas; Barbara O Rothbaum; Kerry J Ressler; Tanja Jovanovic; Sanne J H van Rooij Journal: Eur J Psychotraumatol Date: 2022-04-11
Authors: Joseph E Dunsmoor; Josh M Cisler; Gregory A Fonzo; Suzannah K Creech; Charles B Nemeroff Journal: Neuron Date: 2022-03-23 Impact factor: 18.688
Authors: Nathaniel G Harnett; Katherine E Finegold; Lauren A M Lebois; Sanne J H van Rooij; Timothy D Ely; Vishnu P Murty; Tanja Jovanovic; Steven E Bruce; Stacey L House; Francesca L Beaudoin; Xinming An; Donglin Zeng; Thomas C Neylan; Gari D Clifford; Sarah D Linnstaedt; Laura T Germine; Kenneth A Bollen; Scott L Rauch; John P Haran; Alan B Storrow; Christopher Lewandowski; Paul I Musey; Phyllis L Hendry; Sophia Sheikh; Christopher W Jones; Brittany E Punches; Michael C Kurz; Robert A Swor; Lauren A Hudak; Jose L Pascual; Mark J Seamon; Erica Harris; Anna M Chang; Claire Pearson; David A Peak; Robert M Domeier; Niels K Rathlev; Brian J O'Neil; Paulina Sergot; Leon D Sanchez; Mark W Miller; Robert H Pietrzak; Jutta Joormann; Deanna M Barch; Diego A Pizzagalli; John F Sheridan; Steven E Harte; James M Elliott; Ronald C Kessler; Karestan C Koenen; Samuel A McLean; Lisa D Nickerson; Kerry J Ressler; Jennifer S Stevens Journal: Transl Psychiatry Date: 2022-08-08 Impact factor: 7.989
Authors: Audreyana Jagger-Rickels; David Rothlein; Anna Stumps; Travis Clark Evans; John Bernstein; William Milberg; Regina McGlinchey; Joseph DeGutis; Michael Esterman Journal: Transl Psychiatry Date: 2022-06-27 Impact factor: 7.989