Literature DB >> 33007237

Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges.

Shinya Yamanaka1.   

Abstract

Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable diseases and injuries. Both ESCs and iPSCs are already being used in clinical trials. However, we continue to encounter practical issues that limit their use, including their inherent properties of tumorigenicity, immunogenicity, and heterogeneity. Here, I review two decades of research aimed at overcoming these three difficulties.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 33007237     DOI： 10.1016/j.stem.2020.09.014

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  141 in total

1.  Highly Sensitive Detection of Human Pluripotent Stem Cells by Loop-Mediated Isothermal Amplification.

Authors:  Ryota Yasui; Atsuka Matsui; Keisuke Sekine; Satoshi Okamoto; Hideki Taniguchi
Journal:  Stem Cell Rev Rep       Date:  2022-06-03       Impact factor: 5.739

Review 2.  Regenerative medicine clinical readiness.

Authors:  Satsuki Yamada; Atta Behfar; Andre Terzic
Journal:  Regen Med       Date:  2021-02-24       Impact factor: 3.806

Review 3.  Characterization of Tendon-Derived Stem Cells and Rescue Tendon Injury.

Authors:  Bing Wei; Jun Lu
Journal:  Stem Cell Rev Rep       Date:  2021-03-02       Impact factor: 5.739

Review 4.  Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential.

Authors:  Justin Thomas; Ludovic Zimmerlin; Jeffrey S Huo; Michael Considine; Leslie Cope; Elias T Zambidis
Journal:  NPJ Regen Med       Date:  2021-05-17

Review 5.  Bioengineering of the Uterus.

Authors:  Yushi Yoshimasa; Tetsuo Maruyama
Journal:  Reprod Sci       Date:  2021-04-07       Impact factor: 3.060

Review 6.  Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products.

Authors:  Muhammad Sadeqi Nezhad; Meghdad Abdollahpour-Alitappeh; Behzad Rezaei; Mahboubeh Yazdanifar; Alexander Marcus Seifalian
Journal:  Pharm Res       Date:  2021-06-10       Impact factor: 4.200

Review 7.  Extracellular vesicles as delivery systems at nano-/micro-scale.

Authors:  Peiwen Fu; Jianguo Zhang; Haitao Li; Michael Mak; Wenrong Xu; Zhimin Tao
Journal:  Adv Drug Deliv Rev       Date:  2021-08-03       Impact factor: 15.470

8.  Layer-Number-Dependent Effects of Graphene Oxide on the Pluripotency of Mouse Embryonic Stem Cells Through the Regulation of the Interaction Between the Extracellular Matrix and Integrins.

Authors:  Guoxin Jing; Kun Li; Feiyue Sun; Jintong Niu; Rongrong Zhu; Yechang Qian; Shilong Wang
Journal:  Int J Nanomedicine       Date:  2021-06-04

9.  Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency.

Authors:  Meijun Fu; Huan Chen; Zepo Cai; Yihang Yang; Ziyu Feng; Mengying Zeng; Lijun Chen; Yue Qin; Baomei Cai; Pinghui Zhu; Chunhua Zhou; Shengyong Yu; Jing Guo; Jing Liu; Shangtao Cao; Duanqing Pei
Journal:  Cell Regen       Date:  2021-07-02

10.  Dolly at 25… is she '… still goin' strong?'

Authors:  Kevin D Sinclair
Journal:  Reproduction       Date:  2021-06-21       Impact factor: 3.906
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