| Literature DB >> 34212295 |
Meijun Fu1,2,3,4, Huan Chen1,2,4, Zepo Cai1,2,4, Yihang Yang2,3,4, Ziyu Feng5, Mengying Zeng5, Lijun Chen1,2,4, Yue Qin2,3,4, Baomei Cai5, Pinghui Zhu5, Chunhua Zhou2,4, Shengyong Yu2,3,4, Jing Guo2,4, Jing Liu6,7,8, Shangtao Cao9, Duanqing Pei10,11,12,13,14.
Abstract
Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear. Here, we report that FoxD subfamily and FoxG1 accelerate induced pluripotent stem cells (iPSCs) generation from mouse fibroblasts as early as day4 while FoxA and FoxO subfamily impede this process obviously. More importantly, FoxD3, FoxD4 and FoxG1 can replace Oct4 respectively and generate iPSCs with germline transmission together with Sox2 and Klf4. On the contrary, FoxO6 almost totally blocks reprogramming through inhibiting cell proliferation, suppressing the expression of pluripotent genes and hindering the process of mesenchymal to epithelial transition (MET). Thus, our study uncovers unexpected roles of Fox transcription factors in reprogramming and offers new insights into cell fate transition.Entities:
Year: 2021 PMID： 34212295 DOI： 10.1186/s13619-021-00078-4
Source DB: PubMed Journal: Cell Regen ISSN： 2045-9769