Literature DB >> 34358539

Extracellular vesicles as delivery systems at nano-/micro-scale.

Peiwen Fu1, Jianguo Zhang2, Haitao Li3, Michael Mak4, Wenrong Xu5, Zhimin Tao6.   

Abstract

Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission.
Copyright © 2021 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Drug delivery; Exosomes; Extracellular vesicles; Nanomaterials

Mesh：

Substances：

Year:  2021        PMID： 34358539      PMCID： PMC8986465          DOI： 10.1016/j.addr.2021.113910

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  184 in total

1.  In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment.

Authors:  Qian Chen; Chao Wang; Xudong Zhang; Guojun Chen; Quanyin Hu; Hongjun Li; Jinqiang Wang; Di Wen; Yuqi Zhang; Yifei Lu; Guang Yang; Chen Jiang; Jun Wang; Gianpietro Dotti; Zhen Gu
Journal:  Nat Nanotechnol       Date:  2018-12-10       Impact factor: 39.213

Review 2.  Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications.

Authors:  Raziye Mohammadpour; Marina A Dobrovolskaia; Darwin L Cheney; Khaled F Greish; Hamidreza Ghandehari
Journal:  Adv Drug Deliv Rev       Date:  2019-07-08       Impact factor: 15.470

3.  Generation and testing of clinical-grade exosomes for pancreatic cancer.

Authors:  Mayela Mendt; Sushrut Kamerkar; Hikaru Sugimoto; Kathleen M McAndrews; Chia-Chin Wu; Mihai Gagea; Sujuan Yang; Elena V Rodriges Blanko; Qian Peng; Xiaoyan Ma; Joseph R Marszalek; Anirban Maitra; Cassian Yee; Katayoun Rezvani; Elizabeth Shpall; Valerie S LeBleu; Raghu Kalluri
Journal:  JCI Insight       Date:  2018-04-19

4.  Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake.

Authors:  Jiashu Sun; Lu Zhang; Jiuling Wang; Qiang Feng; Dingbin Liu; Qifang Yin; Dongyan Xu; Yujie Wei; Baoquan Ding; Xinghua Shi; Xingyu Jiang
Journal:  Adv Mater       Date:  2014-12-22       Impact factor: 30.849

5.  Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer.

Authors:  Huifang Nie; Xiaodong Xie; Doudou Zhang; Yu Zhou; Bifei Li; Fengqiao Li; Feiyang Li; Yunlong Cheng; Hao Mei; Huan Meng; Lee Jia
Journal:  Nanoscale       Date:  2019-12-13       Impact factor: 7.790

6.  Tuning the Mechanical Properties of Polymer Nanocomposites Filled with Grafted Nanoparticles by Varying the Grafted Chain Length and Flexibility.

Authors:  Zixuan Wang; Zijian Zheng; Jun Liu; Youping Wu; Liqun Zhang
Journal:  Polymers (Basel)       Date:  2016-08-25       Impact factor: 4.329

7.  Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol.

Authors:  Juan Carlos Polanco; Gabriel Rhys Hand; Adam Briner; Chuanzhou Li; Jürgen Götz
Journal:  Acta Neuropathol       Date:  2021-01-08       Impact factor: 17.088

Review 8.  Engineering precision nanoparticles for drug delivery.

Authors:  Michael J Mitchell; Margaret M Billingsley; Rebecca M Haley; Marissa E Wechsler; Nicholas A Peppas; Robert Langer
Journal:  Nat Rev Drug Discov       Date:  2020-12-04       Impact factor: 84.694

9.  Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles.

Authors:  Xiaodong Xie; Huifang Nie; Yu Zhou; Shu Lian; Hao Mei; Yusheng Lu; Haiyan Dong; Fengqiao Li; Tao Li; Bifei Li; Jie Wang; Min Lin; Chaihung Wang; Jingwei Shao; Yu Gao; Jianming Chen; Fangwei Xie; Lee Jia
Journal:  Nat Commun       Date:  2019-12-02       Impact factor: 14.919

Review 10.  Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications.

Authors:  Austin Gowen; Farah Shahjin; Subhash Chand; Katherine E Odegaard; Sowmya V Yelamanchili
Journal:  Front Cell Dev Biol       Date:  2020-03-12
View more
  12 in total

Review 1.  Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.

Authors:  Francesca Garello; Yulia Svenskaya; Bogdan Parakhonskiy; Miriam Filippi
Journal:  Pharmaceutics       Date:  2022-05-26       Impact factor: 6.525

Review 2.  Mesenchymal Stem Cells and Their Small Extracellular Vesicles as Crucial Immunological Efficacy for Hepatic Diseases.

Authors:  Yuting Tang; Peipei Wu; Linli Li; Wenrong Xu; Jiajia Jiang
Journal:  Front Immunol       Date:  2022-05-06       Impact factor: 8.786

3.  Exploiting Extracellular Vesicles Strategies to Modulate Cell Death and Inflammation in COVID-19.

Authors:  Barbara Bortot; Arianna Romani; Giuseppe Ricci; Stefania Biffi
Journal:  Front Pharmacol       Date:  2022-05-20       Impact factor: 5.988

4.  MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation.

Authors:  Benshuai You; Can Jin; Jiaxin Zhang; Min Xu; Wenrong Xu; Zixuan Sun; Hui Qian
Journal:  Stem Cells Int       Date:  2022-01-18       Impact factor: 5.443

5.  Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes.

Authors:  Yitong Guo; Zhuo Wan; Ping Zhao; Mengying Wei; Yunnan Liu; Te Bu; Wenqi Sun; Zhelong Li; Lijun Yuan
Journal:  J Nanobiotechnology       Date:  2021-12-04       Impact factor: 10.435

Review 6.  The emerging roles of exosomal long non-coding RNAs in bladder cancer.

Authors:  Qiang Liu
Journal:  J Cell Mol Med       Date:  2022-01-03       Impact factor: 5.310

Review 7.  The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy.

Authors:  Juan Li; Guo Zhang; Chen-Guang Liu; Xiaoqiang Xiang; Minh T N Le; Gautam Sethi; Lingzhi Wang; Boon-Cher Goh; Zhaowu Ma
Journal:  Theranostics       Date:  2022-01-01       Impact factor: 11.600

Review 8.  Exosomes: Insights and therapeutic applications in cancer.

Authors:  Anita Raj Panigrahi; Lankalapalli Srinivas; Jagadeesh Panda
Journal:  Transl Oncol       Date:  2022-05-09       Impact factor: 4.803

9.  Engineered exosome-mediated delivery of circDIDO1 inhibits gastric cancer progression via regulation of MiR-1307-3p/SOCS2 Axis.

Authors:  Zhen Guo; Yu Zhang; Wenrong Xu; Xu Zhang; Jiajia Jiang
Journal:  J Transl Med       Date:  2022-07-21       Impact factor: 8.440

Review 10.  Therapeutic Applications of Extracellular Vesicles for Myocardial Repair.

Authors:  Chunping Liu; Nathan Bayado; Dongyue He; Jie Li; Huiqi Chen; Longmei Li; Jinhua Li; Xinyao Long; Tingting Du; Jing Tang; Yue Dang; Zhijin Fan; Lei Wang; Phillip C Yang
Journal:  Front Cardiovasc Med       Date:  2021-12-09
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.