Literature DB >> 32805219

Enzymatic Reactions inside Biological Condensates.

Yi Zhang1, Geeta J Narlikar2, Tatiana G Kutateladze3.   

Abstract

Biological enzymes significantly speed up chemical reactions in living organisms. The complex environment within cells has long been appreciated as a major regulator of enzymatic activities. Recent advances in the rapidly evolving field of biological condensates, which are spontaneously formed by macromolecules through phase separation, suggest new possibilities for how enzymatic reactions may be modulated within cells. Here, we review the latest studies of enzymatic reactions in biological condensates focusing on basic concepts in enzymology and discussing some context-dependent roles of phase separation in regulating biochemical reactions.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  condensates; enzyme; phase separation; reaction

Mesh：

Substances：

Year:  2020        PMID： 32805219      PMCID： PMC9089403          DOI： 10.1016/j.jmb.2020.08.009

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   6.151


  39 in total

Review 1.  The depth of chemical time and the power of enzymes as catalysts.

Authors:  R Wolfenden; M J Snider
Journal:  Acc Chem Res       Date:  2001-12       Impact factor: 22.384

2.  Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

Authors:  Tae Hun Kim; Brian Tsang; Robert M Vernon; Nahum Sonenberg; Lewis E Kay; Julie D Forman-Kay
Journal:  Science       Date:  2019-08-23       Impact factor: 47.728

3.  Quantifying enzyme activity in living cells.

Authors:  Agnes Zotter; Felix Bäuerle; Debabrata Dey; Vladimir Kiss; Gideon Schreiber
Journal:  J Biol Chem       Date:  2017-08-07       Impact factor: 5.157

4.  Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response.

Authors:  Johannes H Wilbertz; Franka Voigt; Ivana Horvathova; Gregory Roth; Yinxiu Zhan; Jeffrey A Chao
Journal:  Mol Cell       Date:  2019-01-17       Impact factor: 17.970

5.  Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect.

Authors:  M I Page; W P Jencks
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205

6.  Peptide-nucleotide microdroplets as a step towards a membrane-free protocell model.

Authors:  Shogo Koga; David S Williams; Adam W Perriman; Stephen Mann
Journal:  Nat Chem       Date:  2011-08-07       Impact factor: 24.427

7.  Composition-dependent thermodynamics of intracellular phase separation.

Authors:  Joshua A Riback; Lian Zhu; Mylene C Ferrolino; Michele Tolbert; Diana M Mitrea; David W Sanders; Ming-Tzo Wei; Richard W Kriwacki; Clifford P Brangwynne
Journal:  Nature       Date:  2020-05-06       Impact factor: 49.962

8.  Coexisting Liquid Phases Underlie Nucleolar Subcompartments.

Authors:  Marina Feric; Nilesh Vaidya; Tyler S Harmon; Diana M Mitrea; Lian Zhu; Tiffany M Richardson; Richard W Kriwacki; Rohit V Pappu; Clifford P Brangwynne
Journal:  Cell       Date:  2016-05-19       Impact factor: 41.582

9.  Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles.

Authors:  Timothy J Nott; Evangelia Petsalaki; Patrick Farber; Dylan Jervis; Eden Fussner; Anne Plochowietz; Timothy D Craggs; David P Bazett-Jones; Tony Pawson; Julie D Forman-Kay; Andrew J Baldwin
Journal:  Mol Cell       Date:  2015-03-05       Impact factor: 17.970

10.  Light-based control of metabolic flux through assembly of synthetic organelles.

Authors:  Evan M Zhao; Nathan Suek; Maxwell Z Wilson; Elliot Dine; Nicole L Pannucci; Zemer Gitai; José L Avalos; Jared E Toettcher
Journal:  Nat Chem Biol       Date:  2019-05-13       Impact factor: 15.040
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  8 in total

1.  Histone H3 and H4 tails play an important role in nucleosome phase separation.

Authors:  Erin F Hammonds; Megan Cleland Harwig; Emeleeta A Paintsil; Emma A Tillison; R Blake Hill; Emma A Morrison
Journal:  Biophys Chem       Date:  2022-02-02       Impact factor: 2.352

2.  Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.

Authors:  Lin Dang; Xinyi Cao; Tianye Zhang; Yongzhan Sun; Shanshan Tian; Tianyu Gong; Hui Xiong; Peipei Cao; Yuhao Li; Shengqiang Yu; Li Yang; Lirong Zhang; Tong Liu; Kai Zhang; Jing Liang; Yupeng Chen
Journal:  J Am Soc Nephrol       Date:  2022-08-02       Impact factor: 14.978

Review 3.  Protein conformation and biomolecular condensates.

Authors:  Diego S Vazquez; Pamela L Toledo; Alejo R Gianotti; Mario R Ermácora
Journal:  Curr Res Struct Biol       Date:  2022-09-14

Review 4.  Biomolecular Condensates and Cancer.

Authors:  Ann Boija; Isaac A Klein; Richard A Young
Journal:  Cancer Cell       Date:  2021-01-07       Impact factor: 31.743

Review 5.  Collaboration through chromatin: motors of transcription and chromatin structure.

Authors:  Nathan Gamarra; Geeta J Narlikar
Journal:  J Mol Biol       Date:  2021-02-05       Impact factor: 6.151

6.  The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation.

Authors:  Sébastien Lyonnais; S Kashif Sadiq; Cristina Lorca-Oró; Laure Dufau; Sara Nieto-Marquez; Tuixent Escribà; Natalia Gabrielli; Xiao Tan; Mohamed Ouizougun-Oubari; Josephine Okoronkwo; Michèle Reboud-Ravaux; José Maria Gatell; Roland Marquet; Jean-Christophe Paillart; Andreas Meyerhans; Carine Tisné; Robert J Gorelick; Gilles Mirambeau
Journal:  Viruses       Date:  2021-11-19       Impact factor: 5.048

Review 7.  Nuclear Protein Condensates and Their Properties in Regulation of Gene Expression.

Authors:  Wei Li; Hao Jiang
Journal:  J Mol Biol       Date:  2021-07-14       Impact factor: 6.151

8.  Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.

Authors:  Yi Zhang; Kyle Brown; Yucong Yu; Ziad Ibrahim; Mohamad Zandian; Hongwen Xuan; Steven Ingersoll; Thomas Lee; Christopher C Ebmeier; Jiuyang Liu; Daniel Panne; Xiaobing Shi; Xiaojun Ren; Tatiana G Kutateladze
Journal:  Nat Commun       Date:  2021-07-29       Impact factor: 17.694
  8 in total

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