Literature DB >> 3277172

Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA.

S K Hanks1, R Armour, J H Baldwin, F Maldonado, J Spiess, R W Holley.   

Abstract

The complete amino acid sequence of the BSC-1 cell growth inhibitor, including its precursor polypeptide, is reported. The sequence was deduced from the nucleotide sequence of the cDNA. The N-terminal amino acid sequence of the mature bioactive BSC-1 cell growth inhibitor is identical with the N-terminal sequences of the factors that have been called type beta 2 transforming growth factor and cartilage-inducing factor B, suggesting that these are identical. The complete amino acid sequence of the mature BSC-1 cell growth inhibitor differs from that of human type beta transforming growth factor in 32 of the 112 amino acids. Polyergin is proposed as the name for the BSC-1 cell growth inhibitor.

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Year:  1988        PMID: 3277172      PMCID: PMC279485          DOI: 10.1073/pnas.85.1.79

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  20 in total

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4.  Purification of kidney epithelial cell growth inhibitors.

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Review 5.  Processing mechanisms in the biosynthesis of proteins.

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7.  DNA sequencing with chain-terminating inhibitors.

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  27 in total

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