Literature DB >> 2519621

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

A B Glick1, K C Flanders, D Danielpour, S H Yuspa, M B Sporn.   

Abstract

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

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Year:  1989        PMID： 2519621      PMCID： PMC361428          DOI： 10.1091/mbc.1.1.87

Source DB:  PubMed          Journal:  Cell Regul        ISSN： 1044-2030


  43 in total

1.  Metaplasia produced in cultures of chick ectoderm by high vitamin A.

Authors:  H B FELL; E MELLANBY
Journal:  J Physiol       Date:  1953-03       Impact factor: 5.182

2.  Growth modulation of mouse keratinocytes by transforming growth factors.

Authors:  R J Coffey; N J Sipes; C C Bascom; R Graves-Deal; C Y Pennington; B E Weissman; H L Moses
Journal:  Cancer Res       Date:  1988-03-15       Impact factor: 12.701

3.  Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells.

Authors:  B S Komm; C M Terpening; D J Benz; K A Graeme; A Gallegos; M Korc; G L Greene; B W O'Malley; M R Haussler
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

4.  Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

Authors:  J Pfeilschifter; G R Mundy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

5.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

6.  Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells.

Authors:  S Y Wang; G J LaRosa; L J Gudas
Journal:  Dev Biol       Date:  1985-01       Impact factor: 3.582

7.  Differential effects of retinoids on DNA synthesis in calcium-regulated murine epidermal keratinocyte cultures.

Authors:  P S Tong; D M Mayes; L A Wheeler
Journal:  J Invest Dermatol       Date:  1988-06       Impact factor: 8.551

8.  Response of epidermal cell proliferation to orally administered aromatic retinoid.

Authors:  P O Fritsch; G Pohlin; U Längle; P M Elias
Journal:  J Invest Dermatol       Date:  1981-09       Impact factor: 8.551

9.  Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

Authors:  R de Martin; B Haendler; R Hofer-Warbinek; H Gaugitsch; M Wrann; H Schlüsener; J M Seifert; S Bodmer; A Fontana; E Hofer
Journal:  EMBO J       Date:  1987-12-01       Impact factor: 11.598

10.  Distribution and modulation of the cellular receptor for transforming growth factor-beta.

Authors:  L M Wakefield; D M Smith; T Masui; C C Harris; M B Sporn
Journal:  J Cell Biol       Date:  1987-08       Impact factor: 10.539
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  54 in total

1.  c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid.

Authors:  G J Fisher; S Datta; Z Wang; X Y Li; T Quan; J H Chung; S Kang; J J Voorhees
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

2.  Preservation and expansion of the primate keratocyte phenotype by downregulating TGF-beta signaling in a low-calcium, serum-free medium.

Authors:  Tetsuya Kawakita; Edgar M Espana; Hua He; Robert Smiddy; Jean-Marie Parel; Chia-Yang Liu; Scheffer C G Tseng
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-05       Impact factor: 4.799

Review 3.  The extracellular regulation of growth factor action.

Authors:  R Flaumenhaft; D B Rifkin
Journal:  Mol Biol Cell       Date:  1992-10       Impact factor: 4.138

Review 4.  TGF-beta: problems and prospects.

Authors:  M B Sporn; A B Roberts
Journal:  Cell Regul       Date:  1990-11

5.  Microarray analysis of microRNA expression in skin of Xpc⁺/⁻ mice and wild-type mice.

Authors:  B Zhou; H Wu; W Li; W Liu; D Luo
Journal:  Ir J Med Sci       Date:  2010-10-26       Impact factor: 1.568

Review 6.  Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells.

Authors:  J Rodrigo Mora; Ulrich H von Andrian
Journal:  Semin Immunol       Date:  2008-09-18       Impact factor: 11.130

Review 7.  Retinoic acid in the immune system.

Authors:  Karina Pino-Lagos; Micah J Benson; Randolph J Noelle
Journal:  Ann N Y Acad Sci       Date:  2008-11       Impact factor: 5.691

8.  The hormetic morphogen theory of curvature and the morphogenesis and pathology of tubular and other curved structures.

Authors:  Egil Fosslien
Journal:  Dose Response       Date:  2009-10-16       Impact factor: 2.658

9.  Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

Authors:  J R Merwin; W Newman; L D Beall; A Tucker; J Madri
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

10.  Aberrant T-cell function in vitro and impaired T-cell dependent antibody response in vivo in vitamin A-deficient rats.

Authors:  U Wiedermann; L A Hanson; H Kahu; U I Dahlgren
Journal:  Immunology       Date:  1993-12       Impact factor: 7.397
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