J Kim1, K Mamoto2, R Lartey3, K Xu4, K Nakamura5, W Shin6, C S Winalski7, N Obuchowski8, M Tanaka9, E Bahroos10, T M Link11, P A Hardy12, Q Peng13, R Reddy14, A Botto-van Bemden15, K Liu16, R D Peters17, C Wu18, X Li19. 1. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. 2. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: mamoto7@hotmail.com. 3. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: LARTEYR@ccf.org. 4. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: kaipin_xu@163.com. 5. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: Nakamuk@ccf.org. 6. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: wanyong.shin@gmail.com. 7. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: winalsc@ccf.org. 8. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: ObuchoN@ccf.org. 9. Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA. Electronic address: Matthew.Tanaka@ucsf.edu. 10. Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA. Electronic address: Emma.Bahroos@ucsf.edu. 11. Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA. Electronic address: Thomas.Link@ucsf.edu. 12. Department of Radiology, University of Kentucky, Lexington KY, USA. Electronic address: Peter.Hardy@uky.edu. 13. Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. Electronic address: dr.chrispeng@gmail.com. 14. Perelman School of Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: krr@pennmedicine.upenn.edu. 15. Arthritis Foundation, GA, USA. Electronic address: avanbemden@hotmail.com. 16. Siemens Medical Solution Inc, USA. Electronic address: Kecheng.liu@siemens-healthineeers.com. 17. GE Healthcare, Waukesha, WI, USA. Electronic address: Robert.Peters@med.ge.com. 18. Philips Healthcare, Andover, MA, USA. Electronic address: can.wu@philips.com. 19. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: lix6@ccf.org.
Abstract
OBJECTIVE: To develop 3D T1ρ and T2 imaging based on the same sequence structure on MR systems from multiple vendors, and to evaluate intra-site repeatability and inter-site inter-vendor reproducibility of T1ρ and T2 measurements of knee cartilage. METHODS: 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS) were implemented on MR systems from Siemens, GE and Philips. Phantom and human subject data were collected at four sites using 3T MR systems from the three vendors with harmonized protocols. Phantom data were collected by means of different positioning of the coil. Volunteers were scanned and rescanned after repositioning. Two traveling volunteers were scanned at all sites. Data were transferred to one site for centralized processing. RESULTS: Intra-site average coefficient of variations (CVs) ranged from 1.09% to 3.05% for T1ρ and 1.78-3.30% for T2 in phantoms, and 1.60-3.93% for T1ρ and 1.44-4.08% for T2 in volunteers. Inter-site average CVs were 5.23% and 6.45% for MAPSS T1ρ and T2, respectively in phantoms, and 8.14% and 10.06% for MAPSS T1ρ and T2, respectively, In volunteers. CONCLUSION: This study showed promising results of multi-site, multi-vendor reproducibility of T1ρ and T2 values in knee cartilage. These quantitative measures may be applied in large-scale multi-site, multi-vendor trials with controlled sequence structure and scan parameters and centralized data processing.
OBJECTIVE: To develop 3D T1ρ and T2 imaging based on the same sequence structure on MR systems from multiple vendors, and to evaluate intra-site repeatability and inter-site inter-vendor reproducibility of T1ρ and T2 measurements of knee cartilage. METHODS: 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS) were implemented on MR systems from Siemens, GE and Philips. Phantom and human subject data were collected at four sites using 3T MR systems from the three vendors with harmonized protocols. Phantom data were collected by means of different positioning of the coil. Volunteers were scanned and rescanned after repositioning. Two traveling volunteers were scanned at all sites. Data were transferred to one site for centralized processing. RESULTS: Intra-site average coefficient of variations (CVs) ranged from 1.09% to 3.05% for T1ρ and 1.78-3.30% for T2 in phantoms, and 1.60-3.93% for T1ρ and 1.44-4.08% for T2 in volunteers. Inter-site average CVs were 5.23% and 6.45% for MAPSS T1ρ and T2, respectively in phantoms, and 8.14% and 10.06% for MAPSS T1ρ and T2, respectively, In volunteers. CONCLUSION: This study showed promising results of multi-site, multi-vendor reproducibility of T1ρ and T2 values in knee cartilage. These quantitative measures may be applied in large-scale multi-site, multi-vendor trials with controlled sequence structure and scan parameters and centralized data processing.
Authors: Miriam G Cisternas; Louise Murphy; Jeffrey J Sacks; Daniel H Solomon; David J Pasta; Charles G Helmick Journal: Arthritis Care Res (Hoboken) Date: 2016-05 Impact factor: 4.794
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Authors: John J Elias; Mei Li; Mingrui Yang; Richard Lartey; John P Murray; Lutul D Farrow; Carl S Winalski; Xiaojuan Li Journal: Cartilage Date: 2022 Apr-Jun Impact factor: 3.117
Authors: Mohamed Jarraya; Rafael Heiss; Jeffrey Duryea; Armin M Nagel; John A Lynch; Ali Guermazi; Marc-André Weber; Andreas Arkudas; Raymund E Horch; Michael Uder; Frank W Roemer Journal: Diagnostics (Basel) Date: 2021-01-12