Literature DB >> 32734589

Recent strategies in the synthesis of thiophene derivatives: highlights from the 2012-2020 literature.

Fahimeh Abedinifar1, Elham Babazadeh Rezaei1, Mahmood Biglar1, Bagher Larijani1, Halleh Hamedifar2, Samira Ansari3, Mohammad Mahdavi4.   

Abstract

Thiophene-based analogs have been fascinated by a growing number of scientists as a potential class of biologically active compounds. Furthermore, they play a vital role for medicinal chemists to improve advanced compounds with a variety of biological effects. The current review envisioned to highlight some recent and particularly remarkable examples of the synthesis of thiophene derivatives by heterocyclization of various substrates from 2012 on.
© 2020. Springer Nature Switzerland AG.

Entities:  

Keywords:  Biological activity; Heterocyclization; Medicinal application; Synthesis; Thiophene

Mesh：

Substances：

Year:  2020        PMID： 32734589     DOI： 10.1007/s11030-020-10128-9

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  41 in total

1.  Rhodium Thiavinyl Carbenes from 1,2,3-Thiadiazoles Enable Modular Synthesis of Multisubstituted Thiophenes.

Authors:  Daria Kurandina; Vladimir Gevorgyan
Journal:  Org Lett       Date:  2016-03-25       Impact factor: 6.005

2.  Rhodium-Catalyzed Intramolecular Transannulation Reaction of Alkynyl Thiadiazole Enabled 5,n-Fused Thiophenes.

Authors:  Ji Eun Kim; Jinsub Lee; Hyunsik Yun; Yonghyeon Baek; Phil Ho Lee
Journal:  J Org Chem       Date:  2017-01-25       Impact factor: 4.354

3.  Copper-Catalyzed Radical C-C Bond Cleavage and [4+1] Annulation Cascade of Cycloketone Oxime Esters with Enaminothiones.

Authors:  Yuan He; Jiang Lou; Kaikai Wu; Hongmei Wang; Zhengkun Yu
Journal:  J Org Chem       Date:  2019-01-29       Impact factor: 4.354

4.  Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes.

Authors:  Ya-Nan Wu; Rong Fu; Nan-Nan Wang; Wen-Juan Hao; Guigen Li; Shu-Jiang Tu; Bo Jiang
Journal:  J Org Chem       Date:  2016-05-24       Impact factor: 4.354

Review 5.  Clinical pharmacokinetics of articaine.

Authors:  R Oertel; R Rahn; W Kirch
Journal:  Clin Pharmacokinet       Date:  1997-12       Impact factor: 6.447

6.  Tetra substituted thiophenes as anti-inflammatory agents: exploitation of analogue-based drug design.

Authors:  Ajay D Pillai; Parendu D Rathod; Franklin P Xavier; Harish Padh; Vasudevan Sudarsanam; Kamala K Vasu
Journal:  Bioorg Med Chem       Date:  2005-08-24       Impact factor: 3.641

7.  Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety.

Authors:  Tamer Nasr; Samir Bondock; Sameh Eid
Journal:  Eur J Med Chem       Date:  2014-07-16       Impact factor: 6.514

8.  Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides.

Authors:  Li-Shi Ge; Zheng-Lin Wang; Xing-Lan An; Xiaoyan Luo; Wei-Ping Deng
Journal:  Org Biomol Chem       Date:  2014-11-14       Impact factor: 3.876

9.  Copper-Catalyzed One-Pot Cross-Dehydrogenative Thienannulation: Chemoselective Access to Naphtho[2,1-b]thiophene-4,5-diones and Subsequent Transformation to Benzo[a]thieno[3,2-c]phenazines.

Authors:  Gaurav Shukla; Abhijeet Srivastava; Dhananjay Yadav; Maya Shankar Singh
Journal:  J Org Chem       Date:  2018-01-26       Impact factor: 4.354

Review 10.  Therapeutic importance of synthetic thiophene.

Authors:  Rashmi Shah; Prabhakar Kumar Verma
Journal:  Chem Cent J       Date:  2018-12-19       Impact factor: 4.215
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  2 in total

Review 1.  Thiophenes-Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors.

Authors:  Sabrin R M Ibrahim; Abdelsattar M Omar; Alaa A Bagalagel; Reem M Diri; Ahmad O Noor; Diena M Almasri; Shaimaa G A Mohamed; Gamal A Mohamed
Journal:  Plants (Basel)       Date:  2022-02-17

2.  Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors.

Authors:  Yaqing Zuo; Rongrong Li; Yan Zhang; Guochen Bao; Yi Le; Longjia Yan
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756
  2 in total

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