Literature DB >> 32605475

Gene signature and prognostic merit of M6a regulators in colorectal cancer.

Jinfeng Zhang1, Xuedi Cheng2, Junzheng Wang3, Yongjie Huang4, Junhui Yuan5, Dawen Guo1.   

Abstract

IMPACT STATEMENT: Although new diagnostic techniques and treatments are increasingly updated for CRC, the clinical outcomes of CRC patients are still not encouraging with a low survival rate. N6-methyladenosine (m6A) as a popular modification on mRNA is associated with multiple types of cancers. Our purpose is to identify gene signature and prognostic ability of m6A modulators in CRC. For the first time, we identified genetic changes of m6A modulators and built prognostic gene signature in CRC, which may provide effective targets for the diagnosis and management of CRC.

Entities:  

Keywords:  Colorectal cancer; N6-methyladenosine RNA methylation; TCGA; bioinformatics; prognostic signature

Mesh：

Substances：

Year:  2020        PMID： 32605475      PMCID： PMC7441353          DOI： 10.1177/1535370220936145

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  32 in total

Review 1.  Gene expression regulation mediated through reversible m⁶A RNA methylation.

Authors:  Ye Fu; Dan Dominissini; Gideon Rechavi; Chuan He
Journal:  Nat Rev Genet       Date:  2014-03-25       Impact factor: 53.242

Review 2.  Colorectal carcinoma screening: Established methods and emerging technology.

Authors:  Erika Hissong; Meredith E Pittman
Journal:  Crit Rev Clin Lab Sci       Date:  2019-10-11       Impact factor: 6.250

3.  Exploration of potential key pathways and genes in multiple ocular cancers through bioinformatics analysis.

Authors:  Qi Wan; Jing Tang
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2019-07-15       Impact factor: 3.117

Review 4.  The role of m6A RNA methylation in cancer.

Authors:  Ting Sun; Ruiyan Wu; Liang Ming
Journal:  Biomed Pharmacother       Date:  2019-02-19       Impact factor: 6.529

Review 5.  Functions of RNA N6-methyladenosine modification in cancer progression.

Authors:  Bing Chen; Ya Li; Ruifeng Song; Chen Xue; Feng Xu
Journal:  Mol Biol Rep       Date:  2019-03-25       Impact factor: 2.316

Review 6.  Emerging function of N6-methyladenosine in cancer.

Authors:  Kwonho Hong
Journal:  Oncol Lett       Date:  2018-09-04       Impact factor: 2.967

7.  m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas.

Authors:  Rui-Chao Chai; Fan Wu; Qi-Xue Wang; Shu Zhang; Ke-Nan Zhang; Yu-Qing Liu; Zheng Zhao; Tao Jiang; Yong-Zhi Wang; Chun-Sheng Kang
Journal:  Aging (Albany NY)       Date:  2019-02-27       Impact factor: 5.682

8.  Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA.

Authors:  Gang Bao; Jianjun Huang; Wei Pan; Xing Li; Tian Zhou
Journal:  Cancer Med       Date:  2019-11-08       Impact factor: 4.452

9.  YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma.

Authors:  Jiajie Hou; He Zhang; Jun Liu; Zhenjun Zhao; Jianye Wang; Zhike Lu; Bian Hu; Jiankui Zhou; Zhicong Zhao; Mingxuan Feng; Haiyan Zhang; Bin Shen; Xingxu Huang; Beicheng Sun; Mark J Smyth; Chuan He; Qiang Xia
Journal:  Mol Cancer       Date:  2019-11-18       Impact factor: 27.401

10.  Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer.

Authors:  Yujiro Nishizawa; Masamitsu Konno; Ayumu Asai; Jun Koseki; Koichi Kawamoto; Norikatsu Miyoshi; Hidekazu Takahashi; Naohiro Nishida; Naotsugu Haraguchi; Daisuke Sakai; Toshihiro Kudo; Taishi Hata; Chu Matsuda; Tsunekazu Mizushima; Taroh Satoh; Yuichiro Doki; Masaki Mori; Hideshi Ishii
Journal:  Oncotarget       Date:  2017-12-21
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  4 in total

Review 1.  N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer.

Authors:  Yiling Ge; Tong Liu; Chuntao Wang; Yanqiu Zhang; Siyi Xu; Yiyi Ren; Yanlu Feng; Lihong Yin; Yuepu Pu; Geyu Liang
Journal:  RNA Biol       Date:  2021-10-21       Impact factor: 4.766

Review 2.  Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer.

Authors:  Shunhao Zhang; Jing Sun; Minqi Gu; Guihua Wang; Xudong Wang
Journal:  Cancer Med       Date:  2021-11-18       Impact factor: 4.452

3.  Links Between N 6-Methyladenosine and Tumor Microenvironments in Colorectal Cancer.

Authors:  Yundi Zhang; Ke Zhang; Haoming Gong; Qin Li; Lajie Man; Qingchang Jin; Lin Zhang; Song Li
Journal:  Front Cell Dev Biol       Date:  2022-02-10

Review 4.  The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer.

Authors:  Xinwei Xu; Jintu Huang; Dickson Kofi Wiredu Ocansey; Yuxuan Xia; Zihan Zhao; Zhiwei Xu; Yongmin Yan; Xu Zhang; Fei Mao
Journal:  J Inflamm Res       Date:  2021-07-15
  4 in total

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