Literature DB >> 32490750

Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?

Lu Jiang1, Bernd Schnabl1.   

Abstract

The gut and the liver have a bidirectional communication via the biliary system and the portal vein. The intestinal microbiota and microbial products play an important role for modulating liver diseases such as alcohol-associated liver disease, non-alcoholic fatty liver disease and steatohepatitis, and cholestatic liver diseases. Here, we review the role of the gut microbiota and its products for the pathogenesis and therapy of chronic liver diseases.

Entities:  

Keywords:  alcoholic liver disease; bile acids; microbiome; non-alcoholic fatty liver disease; short-chain fatty acids

Mesh：

Year:  2020        PMID： 32490750      PMCID： PMC7474259          DOI： 10.1152/physiol.00005.2020

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  186 in total

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Authors:  Stig Bengmark
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Review 2.  Alcoholic liver disease: pathogenesis and new therapeutic targets.

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Journal:  Gastroenterology       Date:  2011-09-12       Impact factor: 22.682

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Journal:  Dig Dis Sci       Date:  2015-07-03       Impact factor: 3.199

4.  Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.

Authors:  Rohit Loomba; Victor Seguritan; Weizhong Li; Tao Long; Niels Klitgord; Archana Bhatt; Parambir Singh Dulai; Cyrielle Caussy; Richele Bettencourt; Sarah K Highlander; Marcus B Jones; Claude B Sirlin; Bernd Schnabl; Lauren Brinkac; Nicholas Schork; Chi-Hua Chen; David A Brenner; William Biggs; Shibu Yooseph; J Craig Venter; Karen E Nelson
Journal:  Cell Metab       Date:  2017-05-02       Impact factor: 27.287

5.  Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice.

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Journal:  Alcohol Clin Exp Res       Date:  2011-04-04       Impact factor: 3.455

Review 6.  Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.

Authors:  Mihai G Mehedint; Steven H Zeisel
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2013-05       Impact factor: 4.294

Review 7.  Changes in the Intestinal Microbiome and Alcoholic and Nonalcoholic Liver Diseases: Causes or Effects?

Authors:  Naga S Betrapally; Patrick M Gillevet; Jasmohan S Bajaj
Journal:  Gastroenterology       Date:  2016-03-04       Impact factor: 22.682

Review 8.  Experimental and analytical tools for studying the human microbiome.

Authors:  Justin Kuczynski; Christian L Lauber; William A Walters; Laura Wegener Parfrey; José C Clemente; Dirk Gevers; Rob Knight
Journal:  Nat Rev Genet       Date:  2011-12-16       Impact factor: 53.242

9.  Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease.

Authors:  Lucie Etienne-Mesmin; Matam Vijay-Kumar; Andrew T Gewirtz; Benoit Chassaing
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2016-05-05

Review 10.  Role of Gut Microbiota in Hepatocarcinogenesis.

Authors:  Haripriya Gupta; Gi Soo Youn; Min Jea Shin; Ki Tae Suk
Journal:  Microorganisms       Date:  2019-05-05
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  11 in total

Review 1.  Roles for the mycobiome in liver disease.

Authors:  Suling Zeng; Bernd Schnabl
Journal:  Liver Int       Date:  2022-01-17       Impact factor: 5.828

2.  Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis.

Authors:  Craig Lammert; Andrea S Shin; Huiping Xu; Christopher Hemmerich; Thomas M O'Connell; Naga Chalasani
Journal:  FEMS Microbiol Lett       Date:  2021-04-22       Impact factor: 2.742

3.  Physiology in Perspective: The New Normal-Life in a Pandemic.

Authors:  Gary C Sieck
Journal:  Physiology (Bethesda)       Date:  2020-07-01

4.  The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury.

Authors:  Shahrbanoo Keshavarz Azizi Raftar; Fatemeh Ashrafian; Abbas Yadegar; Arezou Lari; Hamid Reza Moradi; Arefeh Shahriary; Masoumeh Azimirad; Helia Alavifard; Zhaleh Mohsenifar; Mehdi Davari; Farzam Vaziri; Arfa Moshiri; Seyed Davar Siadat; Mohammad Reza Zali
Journal:  Microbiol Spectr       Date:  2021-09-22

5.  The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury.

Authors:  Shahrbanoo Keshavarz Azizi Raftar; Fatemeh Ashrafian; Sara Abdollahiyan; Abbas Yadegar; Hamid Reza Moradi; Morteza Masoumi; Farzam Vaziri; Arfa Moshiri; Seyed Davar Siadat; Mohammad Reza Zali
Journal:  Sci Rep       Date:  2022-02-14       Impact factor: 4.996

6.  Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury.

Authors:  Hesuiyuan Wang; Qing Wang; Chengmao Yang; Mingming Guo; Xiaoyue Cui; Zhe Jing; Yujie Liu; Wanjin Qiao; Hang Qi; Hongyang Zhang; Xu Zhang; Na Zhao; Mengjuan Zhang; Min Chen; Song Zhang; Haijin Xu; Liqing Zhao; Mingqiang Qiao; Zhenzhou Wu
Journal:  Gut Microbes       Date:  2022 Jan-Dec

Review 7.  Overview of the microbiota in the gut-liver axis in viral B and C hepatitis.

Authors:  Maria Adriana Neag; Andrei Otto Mitre; Adrian Catinean; Anca Dana Buzoianu
Journal:  World J Gastroenterol       Date:  2021-11-21       Impact factor: 5.742

Review 8.  Bile Acids, Their Receptors, and the Gut Microbiota.

Authors:  James C Poland; C Robb Flynn
Journal:  Physiology (Bethesda)       Date:  2021-07-01

9.  The gut mycobiome: a novel player in chronic liver diseases.

Authors:  Lu Jiang; Peter Stärkel; Jian-Gao Fan; Derrick Eugene Fouts; Petra Bacher; Bernd Schnabl
Journal:  J Gastroenterol       Date:  2020-11-05       Impact factor: 7.527

10.  Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice.

Authors:  Richa Singhal; Hridgandh Donde; Smita Ghare; Kendall Stocke; Jingwein Zhang; Manicka Vadhanam; Sreelatha Reddy; Leila Gobejishvili; Paula Chilton; Swati Joshi-Barve; Wenke Feng; Craig McClain; Kristi Hoffman; Joseph Petrosino; Marius Vital; Shirish Barve
Journal:  Gut Microbes       Date:  2021 Jan-Dec
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