Literature DB >> 33836051

Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis.

Craig Lammert1, Andrea S Shin1, Huiping Xu2, Christopher Hemmerich3, Thomas M O'Connell4, Naga Chalasani1.   

Abstract

The gut microbiota and metabolome could play a role in primary biliary cholangitis (PBC) progression. We aimed to assess fecal microbiota and fecal short-chain fatty acids (SCFAs) in PBC according to fibrosis. In a cross-sectional study of 23 PBC patients, fecal microbiota and SCFAs were determined using 16S rRNA sequencing and nuclear magnetic resonance spectroscopy, respectively. Fecal acetate and SCFAs were higher in advanced fibrosis. Advanced fibrosis microbiota exhibited decreased alpha diversity, increased Weisella and a distinct community composition. SCFAs correlated with individual taxa in non-advanced fibrosis. Fecal microbiota and SCFAs correspond to fibrosis in PBC.
© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.

Entities:  

Keywords:  acetate; butyrate; metabolome; microbiome; primary biliary cirrhosis; propionate

Mesh：

Substances：

Year:  2021        PMID： 33836051      PMCID： PMC8062329          DOI： 10.1093/femsle/fnab038

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  18 in total

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  5 in total

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  5 in total

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