Leangelo N Hall1, Swapna S Shanbhag2, Ramy Rashad3, James Chodosh1, Hajirah N Saeed4. 1. Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. 2. Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; LV Prasad Eye Institute, Hyderabad, India. 3. Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Tufts University School of Medicine, Boston, MA, USA. 4. Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address: Hajirah_Saeed@meei.harvard.edu.
Abstract
PURPOSE: To evaluate the effect of systemic cyclosporine (CsA) on ocular disease in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients. METHODS: In this retrospective, comparative cohort study at a single center, patients with a diagnosis of SJS/TEN and with at least 3 months of follow up were divided into two groups: those who received systemic CsA and those who did not receive systemic CsA. Best-corrected visual acuity (BCVA) and chronic ocular surface complications score (COCS) at final follow-up were compared between the two groups. RESULTS: The median age and follow-up period of patients was 29 years (range, 1.5-71 years) and 16.8 months (range, 3.67-91.58 months), respectively. BCVA, COCS, meibomian gland dysfunction, limbal stem cell deficiency, and the need for mucous membrane grafting and scleral lenses were not significantly different between patients who received systemic CsA as compared to patients who did not receive systemic CsA. CONCLUSIONS: In this small cohort of patients with SJS/TEN, we could identify no association between the use of systemic CsA as a component of their initial therapy and chronic ocular complications.
PURPOSE: To evaluate the effect of systemic cyclosporine (CsA) on ocular disease in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients. METHODS: In this retrospective, comparative cohort study at a single center, patients with a diagnosis of SJS/TEN and with at least 3 months of follow up were divided into two groups: those who received systemic CsA and those who did not receive systemic CsA. Best-corrected visual acuity (BCVA) and chronic ocular surface complications score (COCS) at final follow-up were compared between the two groups. RESULTS: The median age and follow-up period of patients was 29 years (range, 1.5-71 years) and 16.8 months (range, 3.67-91.58 months), respectively. BCVA, COCS, meibomian gland dysfunction, limbal stem cell deficiency, and the need for mucous membrane grafting and scleral lenses were not significantly different between patients who received systemic CsA as compared to patients who did not receive systemic CsA. CONCLUSIONS: In this small cohort of patients with SJS/TEN, we could identify no association between the use of systemic CsA as a component of their initial therapy and chronic ocular complications.
Authors: L Valeyrie-Allanore; P Wolkenstein; L Brochard; N Ortonne; B Maître; J Revuz; M Bagot; J C Roujeau Journal: Br J Dermatol Date: 2010-10 Impact factor: 9.302
Authors: Mark G Kirchhof; Monica A Miliszewski; Sheena Sikora; Anthony Papp; Jan P Dutz Journal: J Am Acad Dermatol Date: 2014-07-30 Impact factor: 11.527
Authors: Sahar Kohanim; Sotiria Palioura; Hajirah N Saeed; Esen K Akpek; Guillermo Amescua; Sayan Basu; Preston H Blomquist; Charles S Bouchard; John K Dart; Xiaowu Gai; José A P Gomes; Darren G Gregory; Geetha Iyer; Deborah S Jacobs; Anthony J Johnson; Shigeru Kinoshita; Iason S Mantagos; Jodhbir S Mehta; Victor L Perez; Stephen C Pflugfelder; Virender S Sangwan; Kimberly C Sippel; Chie Sotozono; Bhaskar Srinivasan; Donald T H Tan; Radhika Tandon; Scheffer C G Tseng; Mayumi Ueta; James Chodosh Journal: Ocul Surf Date: 2016-02-13 Impact factor: 5.033