| Literature DB >> 23866879 |
Robert A Schwartz1, Patrick H McDonough, Brian W Lee.
Abstract
Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, mucocutaneous disease. TEN has a high mortality rate, making early diagnosis and treatment of paramount importance. New but experimental diagnostic tools that measure serum granulysin and high-mobility group protein B1 (HMGB1) offer the potential to differentiate early TEN from other, less serious drug reactions, but these tests have not been validated and are not readily available. The mainstay of treatment for TEN involves discontinuation of the offending drug, specialized care in an intensive care unit or burn center, and supportive therapy. Pharmacogenetic studies have clearly established a link between human leukocyte antigen allotype and TEN. Human leukocyte antigen testing should be performed on patients of East Asian descent before the initiation of carbamezapine and on all patients before the initiation of abacavir. The effectiveness of systemic steroids, intravenous immunoglobulins, plasmapheresis, cyclosporine, biologics, and other agents is uncertain.Entities:
Keywords: ALDEN; BSA; EM; EMM; EMm; Fas ligand; FasL; GCSF; HLA; HMGB1; IVIG; LTT; N-acetylcysteine; NAC; SCORTEN; SJS; SSSS; Stevens–Johnson syndrome; TEN; TNF; algorithm for drug causality for epidermal necrolysis; biologics; body surface area; cyclosporine; drug eruption; erythema multiforme; erythema multiforme major; erythema multiforme minor; granulocyte colony-stimulating factor; granulysin; high-mobility group protein B1; human leukocyte antigen; intravenous immunoglobulin; lymphocyte transformation testing; penicillin; plasmapheresis; severity of illness score for toxic epidermal necrolysis; staphylococcal scalded skin syndrome; systemic steroids; toxic epidermal necrolysis; tumor necrosis factor
Mesh：
Year: 2013 PMID： 23866879 DOI： 10.1016/j.jaad.2013.05.002
Source DB: PubMed Journal: J Am Acad Dermatol ISSN： 0190-9622 Impact factor: 11.527