| Literature DB >> 26882981 |
Sahar Kohanim1, Sotiria Palioura2, Hajirah N Saeed3, Esen K Akpek4, Guillermo Amescua2, Sayan Basu5, Preston H Blomquist6, Charles S Bouchard7, John K Dart8, Xiaowu Gai3, José A P Gomes9, Darren G Gregory10, Geetha Iyer11, Deborah S Jacobs12, Anthony J Johnson13, Shigeru Kinoshita14, Iason S Mantagos15, Jodhbir S Mehta16, Victor L Perez2, Stephen C Pflugfelder17, Virender S Sangwan5, Kimberly C Sippel18, Chie Sotozono14, Bhaskar Srinivasan11, Donald T H Tan16, Radhika Tandon19, Scheffer C G Tseng20, Mayumi Ueta14, James Chodosh21.
Abstract
Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immune-mediated disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. Part I of this review focused on the systemic aspects of SJS/TEN and was published in the January 2016 issue of this journal. The purpose of Part II is to summarize the ocular manifestations and their management through all phases of SJS/TEN, from acute to chronic. We hope this effort will assist ophthalmologists in their management of SJS/TEN, so that patients with this complex and debilitating disease receive the best possible care and experience the most optimal outcomes in their vision and quality of life.Entities:
Keywords: Stevens-Johnson Syndrome; amniotic membrane transplantation; apoptosis; drug-induced disease; immune-mediated disease; keratinocyte death; keratoprosthesis; ocular surface reconstruction; toxic epidermal necrolysis
Mesh：
Year: 2016 PMID： 26882981 DOI： 10.1016/j.jtos.2016.02.001
Source DB: PubMed Journal: Ocul Surf ISSN： 1542-0124 Impact factor: 5.033