Peng Xu1,2, Jia Yao1, Zhen Li3, Meng Wang2, Linghui Zhou1,2, Guansheng Zhong1, Yi Zheng1,2, Na Li1,2, Zhen Zhai1,2, Si Yang1,2, Ying Wu1,2, Dai Zhang2, Zhijun Dai1. 1. Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People's Republic of China. 2. Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, People's Republic of China. 3. Department of Student Affairs, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, People's Republic of China.
Abstract
INTRODUCTION: Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed to enhance its efficiency and overcome the side effects of chemotherapy. MATERIALS AND METHODS: In this study, we synthesized and characterized mesoporous silica nanoparticles (MSN-DOX-Ce6) loaded with doxorubicin (DOX) and sonosensitizer, chlorin e6 (Ce6). Then, we conducted in vitro and in vivo experiments to explore the antitumor effect of MSN-DOX-Ce6 under ultrasound (US) treatment. RESULTS: The characterization tests showed that the nanoparticles are uniformly sized spheres with mesoporous structure, resulting in a high drug-loading efficiency. In the in vitro experiments, MSN-DOX-Ce6 could effectively inhibit cell proliferation under US but not more than other treatment groups. However, the in vivo studies showed that MSN-DOX-Ce6+US has better antitumor effect than DOX+Ce6+US or DOX alone on xenograft tumor-bearing mice. CONCLUSION: In summary, MSNs showed a great potential for DOX and Ce6 delivery. We concluded that under US, MSN-DOX-Ce6 nanocomposites increase the antitumor effect of DOX and SDT and thereby are a potential treatment for solid tumors.
INTRODUCTION: Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed to enhance its efficiency and overcome the side effects of chemotherapy. MATERIALS AND METHODS: In this study, we synthesized and characterized mesoporous silica nanoparticles (MSN-DOX-Ce6) loaded with doxorubicin (DOX) and sonosensitizer, chlorin e6 (Ce6). Then, we conducted in vitro and in vivo experiments to explore the antitumor effect of MSN-DOX-Ce6 under ultrasound (US) treatment. RESULTS: The characterization tests showed that the nanoparticles are uniformly sized spheres with mesoporous structure, resulting in a high drug-loading efficiency. In the in vitro experiments, MSN-DOX-Ce6 could effectively inhibit cell proliferation under US but not more than other treatment groups. However, the in vivo studies showed that MSN-DOX-Ce6+US has better antitumor effect than DOX+Ce6+US or DOX alone on xenograft tumor-bearing mice. CONCLUSION: In summary, MSNs showed a great potential for DOX and Ce6 delivery. We concluded that under US, MSN-DOX-Ce6 nanocomposites increase the antitumor effect of DOX and SDT and thereby are a potential treatment for solid tumors.
Authors: Heather Nesbitt; Yingjie Sheng; Sukanta Kamila; Keiran Logan; Keith Thomas; Bridgeen Callan; Mark A Taylor; Mark Love; Declan O'Rourke; Paul Kelly; Estelle Beguin; Eleanor Stride; Anthony P McHale; John F Callan Journal: J Control Release Date: 2018-04-11 Impact factor: 9.776
Authors: L A Osminkina; A A Kudryavtsev; S V Zinovyev; A P Sviridov; Yu V Kargina; K P Tamarov; V N Nikiforov; A V Ivanov; A N Vasilyev; V Yu Timoshenko Journal: Bull Exp Biol Med Date: 2016-07-07 Impact factor: 0.804