| Literature DB >> 25461284 |
Ying Wang1, Qinfu Zhao1, Ning Han1, Ling Bai1, Jia Li1, Jia Liu1, Erxi Che1, Liang Hu1, Qiang Zhang1, Tongying Jiang1, Siling Wang2.
Abstract
In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration. FROM THE CLINICAL EDITOR: This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed.Entities:
Keywords: Biocompatibility; Biomedical applications; Drug delivery systems; Mesoporous silica nanoparticles
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Year: 2014 PMID： 25461284 DOI： 10.1016/j.nano.2014.09.014
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307