Literature DB >> 3236017

DNA lability induced by nimustine and ramustine in rat glioma cells.

K Mineura1, S Fushimi, Y Itoh, M Kowada.   

Abstract

The DNA labile sites induced by two nitrosoureas, nimustine (ACNU) and ramustine (MCNU) synthesised in Japan, have been examined in highly reiterated DNA sequences of rat glioma cells. Reiterated fragments of 167 and 203 base pairs (bp), obtained after Hind III and Hae III restriction endonuclease digestion of rat glioma cells DNA, were used as target DNA sequences to determine the labile sites. In vitro reaction with ACNU and MCNU resulted in scission products corresponding to the locations of guanine. Subsequent piperidine hydrolysis produced more frequent breaks of the phosphodiester bonds at guanine positions, thus forming alkali-labile sites.

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Year:  1988        PMID： 3236017      PMCID： PMC1032808          DOI： 10.1136/jnnp.51.11.1391

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  14 in total

1.  Morphological studies of rat brain tumors induced by N-nitrosomethylurea.

Authors:  H H Schmidek; S L Nielsen; A L Schiller; J Messer
Journal:  J Neurosurg       Date:  1971-03       Impact factor: 5.115

2.  The use of DNA fragments of defined sequence for the study of DNA damage and repair.

Authors:  W A Haseltine; C P Lindan; A D D'Andrea; L Johnsrud
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

3.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

4.  Nucleotide sequence of a highly repetitive component of rat DNA.

Authors:  M Pech; T Igo-Kemenes; H G Zachau
Journal:  Nucleic Acids Res       Date:  1979-09-25       Impact factor: 16.971

5.  Effect of 3-[4-amino-2-methyl-5-pyrimidinyl)ethyl[-1(2-chloroethyl)-1-nitrosourea hydrochloride on lymphoid leukemia L-1210.

Authors:  F Shimizu; M Arakawa
Journal:  Gan       Date:  1975-04

6.  Differentiated rat glial cell strain in tissue culture.

Authors:  P Benda; J Lightbody; G Sato; L Levine; W Sweet
Journal:  Science       Date:  1968-07-26       Impact factor: 47.728

7.  Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.

Authors:  M D Walker; S B Green; D P Byar; E Alexander; U Batzdorf; W H Brooks; W E Hunt; C S MacCarty; M S Mahaley; J Mealey; G Owens; J Ransohoff; J T Robertson; W R Shapiro; K R Smith; C B Wilson; T A Strike
Journal:  N Engl J Med       Date:  1980-12-04       Impact factor: 91.245

8.  Effects of ACNU and radiotherapy on malignant glioma.

Authors:  K Takakura; H Abe; R Tanaka; K Kitamura; T Miwa; K Takeuchi; S Yamamoto; N Kageyama; H Handa; H Mogami
Journal:  J Neurosurg       Date:  1986-01       Impact factor: 5.115

9.  Use of an indicator sequence of human DNA to study DNA damage by methylbis(2-chloroethyl)amine.

Authors:  S M Grunberg; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

10.  Biologic activity of MCNU: a new antitumor agent.

Authors:  S Sekido; K Ninomiya; M Iwasaki
Journal:  Cancer Treat Rep       Date:  1979-06
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  3 in total

1.  Enhancement of ACNU cytotoxicity by pretreatment with O6-methylguanine in ACNU-resistant brain tumors.

Authors:  K Mineura; I Izumi; K Watanabe; M Kowada
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

2.  Linkage between O6-methylguanine-DNA methyltransferase (O6-MT) activity and cellular resistance to antitumour nitrosoureas in cultured rat brain tumour cell strains.

Authors:  K Mineura; S Fushimi; M Kowada; G Isowa; K Ishizaki; M Ikenaga
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

3.  A structural insight into major groove directed binding of nitrosourea derivative nimustine with DNA: a spectroscopic study.

Authors:  Shweta Agarwal; Deepak Kumar Jangir; Ranjana Mehrotra; Neelam Lohani; M R Rajeswari
Journal:  PLoS One       Date:  2014-08-07       Impact factor: 3.240
  3 in total

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