Literature DB >> 466655

Biologic activity of MCNU: a new antitumor agent.

S Sekido, K Ninomiya, M Iwasaki.   

Abstract

A novel nitrosourea derivative, methyl-6-[[[(2-chloroethyl)nitrosoamino]carbonyl]-amino]-6-deoxy-alpha-D-glucopyranoside (MCNU), is a water-soluble compound in which a methoxyl group is attached to the C-1 position and an N-(2-chloroethyl)-N-nitrosoureido group is attached to the C-6 position of the glucose moiety. MCNU exhibited a marked life-prolongation or growth-inhibitory effect against mouse L1210 leukemia, adenocarcinoma 755, Nakahara-Fukuoka sarcoma, Lewis lung carcinoma, and B16 melanoma. Ip, oral, or iv administration of MCNU was markedly effective against L1210 leukemia, and the therapeutic ratio by ip administration was larger than that of chlorozotocin or CCNU. The life-prolongation effect of MCNU against established Lewis lung carcinoma was similar to that of methyl-CCNU. The bone marrow toxicity of MCNU was less than that of CCNU but considerably more than that of chlorozotocin.

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Year:  1979        PMID： 466655

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  10 in total

1.  Sensitivity of human malignant intracranial tumors against MCNU in vitro in comparison to ACNU and BCNU.

Authors:  J C Tonn; R Schönmayr; H P Kraemer
Journal:  J Neurooncol       Date:  1990-02       Impact factor: 4.130

2.  Characterization of the anti-tumour activity against solid tumours of a new nitrosoureido sugar: Cy 233.

Authors:  G Atassi; P Dumont; C Gosse; J P Fournier; A Gouyette; P Roger
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

3.  Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma.

Authors:  T Yamashima; T Ohnishi; Y Nakajima; T Terasaki; M Tanaka; J Yamashita; T Sasaki; A Tsuji
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

4.  Antitumor activity of a nitrosourea derivative, CNUA, on murine tumors.

Authors:  K Edanami; K Komiyama; T Kuroda; I Umezawa
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

5.  DNA lability induced by nimustine and ramustine in rat glioma cells.

Authors:  K Mineura; S Fushimi; Y Itoh; M Kowada
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-11       Impact factor: 10.154

6.  Delivery of a novel nitrosourea, MCNU, to the brain tissue in glioma-bearing rats. Intracarotid versus intravenous infusion.

Authors:  A Hodozuka; K Sako; H Nakai; M Tomabechi; N Suzuki; Y Yonemasu
Journal:  J Neurooncol       Date:  1993-01       Impact factor: 4.130

7.  Linkage between O6-methylguanine-DNA methyltransferase (O6-MT) activity and cellular resistance to antitumour nitrosoureas in cultured rat brain tumour cell strains.

Authors:  K Mineura; S Fushimi; M Kowada; G Isowa; K Ishizaki; M Ikenaga
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

8.  A new nitrosourea derivative TA-077, 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea. I. Comparative study on antitumor activity.

Authors:  S Fujimoto; M Ogawa
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

9.  MCNU in the treatment of essential thrombocythemia--a pilot study.

Authors:  H Murakami; J Tamura; M Sawamura
Journal:  Ann Hematol       Date:  1993-05       Impact factor: 3.673

10.  Enhanced antitumor activity and reduced toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea administered in lipid microspheres to tumor-bearing mice.

Authors:  M Takenaga; R Igarashi; H Tsuji; Y Mizushima
Journal:  Jpn J Cancer Res       Date:  1993-10
  10 in total

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