Literature DB >> 323142

Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin.

A D O'Brien, M R Thompson, P Gemski, B P Doctor, S B Formal.   

Abstract

A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.

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Year:  1977        PMID： 323142      PMCID： PMC421442          DOI： 10.1128/iai.15.3.796-798.1977

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  Studies with Vibrio cholerae in the ligated loop of the rabbit intestine.

Authors:  S B FORMAL; D KUNDEL; H SCHNEIDER; H SPRINZ
Journal:  Br J Exp Pathol       Date:  1961-10

2.  The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro.

Authors:  G VICARI; A L OLITZKI; Z OLITZKI
Journal:  Br J Exp Pathol       Date:  1960-04

3.  The neurotoxin of Shigella shigae. I. Production, purification and properties of the toxin.

Authors:  W E VAN HEYNINGEN; G P GLADSTONE
Journal:  Br J Exp Pathol       Date:  1953-04

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Shigellosis due to Shigella dysenteriae. 1. Relative importance of mucosal invasion versus toxin production in pathogenesis.

Authors:  P Gemski; A Takeuchi; O Washington; S B Formal
Journal:  J Infect Dis       Date:  1972-11       Impact factor: 5.226

6.  Inhibition of in vitro protein synthesis by Shigella dysenteriae 1 toxin.

Authors:  M R Thompson; M S Steinberg; P Gemski; S B Formal; B P Doctor
Journal:  Biochem Biophys Res Commun       Date:  1976-08-09       Impact factor: 3.575

7.  Fluorescent-antibody and histological study of vaccinated and control monkeys challenged with Shigella flexneri.

Authors:  S B Formal; T H Kent; S Austin; E H Labrec
Journal:  J Bacteriol       Date:  1966-06       Impact factor: 3.490

8.  The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I.

Authors:  G T Keusch; G F Grady; L J Mata; J McIver
Journal:  J Clin Invest       Date:  1972-05       Impact factor: 14.808

9.  USE OF LIGATED SEGMENTS OF RABBIT SMALL INTESTINE IN EXPERIMENTAL SHIGELLOSIS.

Authors:  H G ARM; T M FLOYD; J E FABER; J R HAYES
Journal:  J Bacteriol       Date:  1965-03       Impact factor: 3.490
  9 in total
  26 in total

1.  Role of Shiga toxin in the pathogenesis of bacillary dysentery, studied by using a Tox- mutant of Shigella dysenteriae 1.

Authors:  A Fontaine; J Arondel; P J Sansonetti
Journal:  Infect Immun       Date:  1988-12       Impact factor: 3.441

Review 2.  Shiga and Shiga-like toxins.

Authors:  A D O'Brien; R K Holmes
Journal:  Microbiol Rev       Date:  1987-06

3.  Pathogenesis of Shigella diarrhea: rabbit intestinal cell microvillus membrane binding site for Shigella toxin.

Authors:  G Fuchs; M Mobassaleh; A Donohue-Rolfe; R K Montgomery; R J Grand; G T Keusch
Journal:  Infect Immun       Date:  1986-08       Impact factor: 3.441

4.  The mode of action of Shiga toxin on peptide elongation of eukaryotic protein synthesis.

Authors:  T G Obrig; T P Moran; J E Brown
Journal:  Biochem J       Date:  1987-06-01       Impact factor: 3.857

5.  Toxin from the culture filtrate of Shigella dysenteriae that causes morphological changes in Chinese hamster ovary cells and is distinct from the neurotoxin.

Authors:  Y Takeda; K Okamoto; T Miwatani
Journal:  Infect Immun       Date:  1977-11       Impact factor: 3.441

6.  Immunochemical and cytotoxic activities of Shigella dysenteriae 1 (shiga) and shiga-like toxins.

Authors:  A D O'Brien; G D Laveck
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

7.  Invasiveness of Aeromonas spp. in relation to biotype, virulence factors, and clinical features.

Authors:  I M Watson; J O Robinson; V Burke; M Gracey
Journal:  J Clin Microbiol       Date:  1985-07       Impact factor: 5.948

8.  Mitomycin C stimulates production of a toxin in Shigella species that causes morphological changes in Chinese hamster ovary cells.

Authors:  Y Takeda; K Okamoto; T Miwatani
Journal:  Infect Immun       Date:  1979-01       Impact factor: 3.441

9.  Enzyme-linked immunosorbent assay for shigella toxin.

Authors:  A Donohue-Rolfe; M A Kelley; M Bennish; G T Keusch
Journal:  J Clin Microbiol       Date:  1986-07       Impact factor: 5.948

10.  Release of Shiga toxin from Shigella dysenteriae 1 by polymyxin B.

Authors:  D E Griffin; P Gemski
Journal:  Infect Immun       Date:  1983-04       Impact factor: 3.441
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