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Literature DB >> 7040247

Immunochemical and cytotoxic activities of Shigella dysenteriae 1 (shiga) and shiga-like toxins.

Abstract

Toxins in culture supernatants and bacterial lysates of S. dysenteriae 1 and S. flexneri were quantitated by a cytotoxicity assay and a newly developed radioimmunoassay. Cytotoxin titers paralleled toxin antigen levels. Thus, variations in cytotoxicity among shigellae probably reflect differences in toxin yield rather than specific activity (cytotoxicity per microgram of toxin antigen).

Entities: Disease Species

Mesh：

Substances：

Year: 1982 PMID： 7040247 PMCID： PMC351168 DOI： 10.1128/iai.35.3.1151-1154.1982

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. Estimation of microgram quantities of iron in culture medium, using bathophenanthroline.

Authors: P A SEAMER
Journal: Nature Date: 1959-08-22 Impact factor: 49.962

2. The neurotoxin of Shigella shigae. I. Production, purification and properties of the toxin.

Authors: W E VAN HEYNINGEN; G P GLADSTONE
Journal: Br J Exp Pathol Date: 1953-04

3. The pathogenesis of shigella diarrhea. II. Enterotoxin-induced acute enteritis in the rabbit ileum.

Authors: G T Keusch; G F Grady; A Takeuchi; H Sprinz
Journal: J Infect Dis Date: 1972-07 Impact factor: 5.226

4. Protein iodination with solid state lactoperoxidase.

Authors: G S David; R A Reisfeld
Journal: Biochemistry Date: 1974-02-26 Impact factor: 3.162

5. Inhibition of protein synthesis in intact HeLa cells by Shigella dysenteriae 1 toxin.

Authors: J E Brown; S W Rothman; B P Doctor
Journal: Infect Immun Date: 1980-07 Impact factor: 3.441

6. Immunochemical studies of diphtherial toxin and related nontoxic mutant proteins.

Authors: S J Cryz; S L Welkos; R K Holmes
Journal: Infect Immun Date: 1980-12 Impact factor: 3.441

7. Production and characterization of exotoxin(s) of Shigella dysenteriae type 1.

Authors: J McIver; G F Grady; G T Keusch
Journal: J Infect Dis Date: 1975-05 Impact factor: 5.226

8. Inhibition of in vitro protein synthesis by Shigella dysenteriae 1 toxin.

Authors: M R Thompson; M S Steinberg; P Gemski; S B Formal; B P Doctor
Journal: Biochem Biophys Res Commun Date: 1976-08-09 Impact factor: 3.575

9. The pathogenesis of Shigella diarrhea. VI. Toxin and antitoxin in Shigella flexneri and Shigella sonnei infections in humans.

Authors: G T Keusch; M Jacewicz
Journal: J Infect Dis Date: 1977-04 Impact factor: 5.226

10. Isolation and characterization of Shigella shigae cytotoxin.

Authors: S Olsnes; K Eiklid
Journal: J Biol Chem Date: 1980-01-10 Impact factor: 5.157

25 in total

1. Identification of a B subunit gene promoter in the Shiga toxin operon of Shigella dysenteriae 1.

Authors: N F Habib; M P Jackson
Journal: J Bacteriol Date: 1992-10 Impact factor: 3.490

2. Cloning of genes for production of Escherichia coli Shiga-like toxin type II.

Authors: J W Newland; N A Strockbine; R J Neill
Journal: Infect Immun Date: 1987-11 Impact factor: 3.441

3. Nucleotide sequence and promoter mapping of the Escherichia coli Shiga-like toxin operon of bacteriophage H-19B.

Authors: S De Grandis; J Ginsberg; M Toone; S Climie; J Friesen; J Brunton
Journal: J Bacteriol Date: 1987-09 Impact factor: 3.490

4. Production of Shiga-like toxin among Escherichia coli strains and other bacteria isolated from diarrhea in São Paulo, Brazil.

Authors: R Giraldi; B E Guth; L R Trabulsi
Journal: J Clin Microbiol Date: 1990-06 Impact factor: 5.948

Review 5. Shiga and Shiga-like toxins.

Authors: A D O'Brien; R K Holmes
Journal: Microbiol Rev Date: 1987-06

6. Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities.

Authors: N A Strockbine; L R Marques; J W Newland; H W Smith; R K Holmes; A D O'Brien
Journal: Infect Immun Date: 1986-07 Impact factor: 3.441

7. Variations in the csgD promoter of Escherichia coli O157:H7 associated with increased virulence in mice and increased invasion of HEp-2 cells.

Authors: Gaylen A Uhlich; James E Keen; Robert O Elder
Journal: Infect Immun Date: 2002-01 Impact factor: 3.441