Peixi Liu1, Mingxi Zeng1. 1. Department of Gastroenterology, Sichuan People Hospital Chendu, China.
Abstract
Background and objective: To further determine the association between mucin 1 (MUC1) rs4072037 polymorphism and gastric cancer risk on the basis of previously published studies. Methodology: PubMed and Embase were used to search all the available publications. The relative risk of the correlation was shown as odds ratio (OR) with 95% confidence interval (95% CI) under all the genetic comparisons. Subgroup analyses based on ethnicity, study design and HWE were also executed to detect effects of specific factors on the risk of gastric cancer. Results: MUC1 rs4072037 polymorphism was observed to reduce the risk of gastric cancer under the five genetic comparisons [(GG versus AA: OR (95% CI)=0.72 (0.61, 0.84); GG + GA versus AA: OR (95% CI)=0.82 (0.76, 0.88); GG versus AA + GA: OR (95% CI)=0.83 (0.71, 0.96); G versus A: OR (95% CI)=0.78 (0.72, 0.84); GA versus AA: OR (95% CI)=0.80 (0.74, 0.87)]. This decreased risk of gastric cancer was also detected in subgroup analyses based on ancestry (Asian and Caucasian), study design (population-based and hospital-based) and HWE (P HWE>0.05). Conclusions: MUC1 rs4072037 polymorphism may have an important role in gastric cancer, and this protective effect may vary among different ethnic populations and control subjects. IJCEP
Background and objective: To further determine the association between mucin 1 (MUC1) rs4072037 polymorphism and gastric cancer risk on the basis of previously published studies. Methodology: PubMed and Embase were used to search all the available publications. The relative risk of the correlation was shown as odds ratio (OR) with 95% confidence interval (95% CI) under all the genetic comparisons. Subgroup analyses based on ethnicity, study design and HWE were also executed to detect effects of specific factors on the risk of gastric cancer. Results:MUC1 rs4072037 polymorphism was observed to reduce the risk of gastric cancer under the five genetic comparisons [(GG versus AA: OR (95% CI)=0.72 (0.61, 0.84); GG + GA versus AA: OR (95% CI)=0.82 (0.76, 0.88); GG versus AA + GA: OR (95% CI)=0.83 (0.71, 0.96); G versus A: OR (95% CI)=0.78 (0.72, 0.84); GA versus AA: OR (95% CI)=0.80 (0.74, 0.87)]. This decreased risk of gastric cancer was also detected in subgroup analyses based on ancestry (Asian and Caucasian), study design (population-based and hospital-based) and HWE (P HWE>0.05). Conclusions: MUC1 rs4072037 polymorphism may have an important role in gastric cancer, and this protective effect may vary among different ethnic populations and control subjects. IJCEP
Authors: Ahmedin Jemal; Freddie Bray; Melissa M Center; Jacques Ferlay; Elizabeth Ward; David Forman Journal: CA Cancer J Clin Date: 2011-02-04 Impact factor: 508.702
Authors: Sara Remuzgo-Martínez; Belén Atienza-Mateo; J Gonzalo Ocejo-Vinyals; Fernanda Genre; Verónica Pulito-Cueto; Víctor M Mora-Cuesta; David Iturbe-Fernández; Leticia Lera-Gómez; Raquel Pérez-Fernández; Diana Prieto-Peña; Juan Irure; Fredeswinda Romero-Bueno; Olga Sanchez-Pernaute; Rodrigo Alonso-Moralejo; Laura Nuño; Gema Bonilla; Esther F Vicente-Rabaneda; Ignacio Grafia; Sergio Prieto-González; Javier Narvaez; Ernesto Trallero-Araguas; Albert Selva-O'Callaghan; Oreste Gualillo; Lorenzo Cavagna; José M Cifrián; Elisabetta A Renzoni; Santos Castañeda; Raquel López-Mejías; Miguel A González-Gay Journal: Sci Rep Date: 2021-11-19 Impact factor: 4.379