| Literature DB >> 33128686 |
Patricio Gonzalez-Hormazabal1, Rocío Retamales-Ortega2, Maher Musleh3, Marco Bustamante4, Juan Stambuk5, Raul Pisano5, Hector Valladares3, Enrique Lanzarini3, Hector Chiong6, Jose Suazo7, Luis A Quiñones8,9, Nelson M Varela8,9, V Gonzalo Castro2, Lilian Jara2, Ricardo A Verdugo2,8, Zoltan Berger10.
Abstract
Genetic variants are considered risk factors for gastric cancer. To date, 61 polymorphisms have been identified as associated with this disease. The aim of the present study was to analyze the association of some of those polymorphisms with GC in Chile. We performed a case-control study including 310 gastric cancer cases and 311 controls to assess the association of 36 single-nucleotide polymorphisms genotyped by Global Screening Array (GSA). Three polymorphisms was significantly associated: PSCA rs2294008 (allele model, OR = 1.49, 95%CI 1.17-1.88, P = 1.08 × 10-3), IL-4 rs2243250 (allele model, OR = 1.28, 95%CI 1.01-1.62, P = 0.04), and MUC1 rs4072037 (allele model, OR = 0.78, 95%CI 0.61-0.99, P = 0.04).PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in Chile. It suggests that those polymorphisms could be used as biomarkers to assess the genetic risk for this cancer outside of the previously studied populations, not only for East Asians and Caucasians populations.Entities:
Keywords: Gastric cancer; IL-4; MUC1; PSCA; Polymorphism
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Year: 2020 PMID： 33128686 DOI： 10.1007/s11033-020-05943-0
Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316