| Literature DB >> 19913432 |
Shantibhusan Senapati1, Srustidhar Das, Surinder K Batra.
Abstract
Mucins are high molecular weight glycoproteins that are involved in regulating diverse cellular activities both in normal and pathological conditions. Mucin activity and localization is mediated by several molecular mechanisms, including discrete interactions with other proteins. An understanding of the biochemistry behind the known interactions between mucins and other proteins, coupled with an appreciation of their pathophysiological significance, can lend insight into the development of novel therapeutic agents. Indeed, a recent study demonstrated that a cell permeable inhibitor, PMIP, that disrupts the MUC1-EGFR interaction, is effective in killing breast cancer cells in vitro and in tumor models. 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19913432 PMCID： PMC3030310 DOI： 10.1016/j.tibs.2009.10.003
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807