Juozas Kupcinskas1, Thomas Wex2, Alexander Link3, Ruta Bartuseviciute4, Milda Dedelaite4, Gintare Kevalaite4, Marcis Leja5, Jurgita Skieceviciene6, Gediminas Kiudelis1, Laimas Jonaitis1, Limas Kupcinskas7, Peter Malfertheiner3. 1. Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania. 2. Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department of Molecular Genetics, Otto von Guericke University, Magdeburg, Germany. 3. Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany. 4. Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania. 5. Faculty of Medicine, University of Latvia, Riga, Latvia Digestive Diseases Center GASTRO, Riga, Latvia Riga East University Hospital, Riga, Latvia. 6. Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania. 7. Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania l.kupcinskas@gmail.com.
Abstract
BACKGROUND/AIM: Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG). MATERIALS AND METHODS: Using TaqMan system, SNPs were genotyped in 252 patients with GC, 136 patients with HRAG and 246 controls. RESULTS: PSCA rs2294008 allele T was associated with risk of GC (odds ratio (OR)=1.88, p<0.001) and HRAG (OR=1.49, p=0.009). Allele A of PSCA rs2976392 was associated with development of GC (OR=1.88, p<0.001) and HRAG (OR=1.56, p<0.01). MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223. CONCLUSION: Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG. Copyright
BACKGROUND/AIM: Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG). MATERIALS AND METHODS: Using TaqMan system, SNPs were genotyped in 252 patients with GC, 136 patients with HRAG and 246 controls. RESULTS:PSCArs2294008 allele T was associated with risk of GC (odds ratio (OR)=1.88, p<0.001) and HRAG (OR=1.49, p=0.009). Allele A of PSCArs2976392 was associated with development of GC (OR=1.88, p<0.001) and HRAG (OR=1.56, p<0.01). MUC1rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1rs2274223. CONCLUSION: Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG. Copyright