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Literature DB >> 32215395

Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.

Nicholas G Paciaroni¹, John M Ndungu, Thomas Kodadek.

Abstract

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

Entities: Chemical Disease Species

Mesh：

Substances：
Aldehydes

Year: 2020 PMID： 32215395 PMCID： PMC7298663 DOI： 10.1039/d0cc01474e

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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3. Solid-Phase Synthesis of β-Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions.

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5. Solid-phase synthesis of diverse peptide tertiary amides by reductive amination.

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7. What is a "DNA-Compatible" Reaction?

Authors: Marie L Malone; Brian M Paegel
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8. In situ generation of the Ohira-Bestmann reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes.

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9. An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis.

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10. Development and Synthesis of DNA-Encoded Benzimidazole Library.

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Review 5. Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA-Displayed Peptide Libraries.

Authors: Paddy R A Melsen; Ryoji Yoshisada; Seino A K Jongkees
Journal: Chembiochem Date: 2022-02-18 Impact factor: 3.461