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Literature DB >> 3205717

An embryonic DNA-binding protein specific for a region of the human IFN beta 1 promoter.

A Haggarty¹, A Ponton, G D Paterno, L Daigneault, D Skup.

Abstract

Embryonal carcinoma (EC) cells are unable to make interferon in response to inducing agents. This block disappears after differentiation. We have found that nuclear extracts from undifferentiated P19 EC cells contain a DNA-binding activity which specifically recognizes a region within the human interferon-beta 1 promoter. This activity is absent from differentiated cell types, both of EC and non-EC origin. The binding of the factor in undifferentiated EC cells leads to dramatic changes in the overall protein binding pattern of the interferon promoter as compared with differentiated cells, and may be responsible for repression of the endogenous interferon-beta gene prior to differentiation.

Entities: Disease Gene Species

Mesh：

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Year: 1988 PMID： 3205717 PMCID： PMC338925 DOI： 10.1093/nar/16.22.10575

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

36 in total

1. Expression of a chemically synthesized human alpha 1 interferon gene.

Authors: E De Maeyer; D Skup; K S Prasad; J De Maeyer-Guignard; B Williams; P Meacock; G Sharpe; D Pioli; J Hennam; W Schuch; K Atherton
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

2. Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

Authors: S Ohno; T Taniguchi
Journal: Nucleic Acids Res Date: 1982-02-11 Impact factor: 16.971

3. Controlled transcription of a human alpha-interferon gene introduced into mouse L cells.

Authors: N Mantei; C Weissmann
Journal: Nature Date: 1982-05-13 Impact factor: 49.962

4. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element.

Authors: P Hearing; T Shenk
Journal: Cell Date: 1983-07 Impact factor: 41.582

5. Isolation of male embryonal carcinoma cells and their chromosome replication patterns.

Authors: M W McBurney; B J Rogers
Journal: Dev Biol Date: 1982-02 Impact factor: 3.582

6. Regulation of translation in L-cells infected with reovirus.

Authors: D Skup; H Zarbl; S Millward
Journal: J Mol Biol Date: 1981-09-05 Impact factor: 5.469

7. Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene.

Authors: T Fujita; S Ohno; H Yasumitsu; T Taniguchi
Journal: Cell Date: 1985-06 Impact factor: 41.582

8. Appearance of interferon inducibility and sensitivity during differentiation of murine teratocarcinoma cells in vitro.

Authors: D C Burke; C F Graham; J M Lehman
Journal: Cell Date: 1978-02 Impact factor: 41.582

An embryonic DNA-binding protein specific for a region of the human IFN beta 1 promoter.

1. Expression of a chemically synthesized human alpha 1 interferon gene.

2. Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

3. Controlled transcription of a human alpha-interferon gene introduced into mouse L cells.

4. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element.

5. Isolation of male embryonal carcinoma cells and their chromosome replication patterns.

6. Regulation of translation in L-cells infected with reovirus.

7. Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene.

8. Appearance of interferon inducibility and sensitivity during differentiation of murine teratocarcinoma cells in vitro.

9. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

10. Deletion mapping of the inducible promoter of human IFN-beta gene.

1. Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells.

2. Two distinct pathways of interferon induction as revealed by 2-aminopurine.

3. Control of beta-interferon expression in murine embryonal carcinoma F9 cells.