Literature DB >> 32054749

Translating preclinical models to humans.

Douglas K Brubaker1, Douglas A Lauffenburger2.   

Abstract

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Year:  2020        PMID： 32054749     DOI： 10.1126/science.aay8086

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


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  11 in total

Review 1.  Current and potential future applications of human stem cell models in drug development.

Authors:  Mark Donowitz; Jerrold R Turner; Alan S Verkman; Nicholas Constantine Zachos
Journal:  J Clin Invest       Date:  2020-07-01       Impact factor: 14.808

Review 2.  Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives.

Authors:  Christina-Maria Flessa; Ioannis Kyrou; Narjes Nasiri-Ansari; Gregory Kaltsas; Athanasios G Papavassiliou; Eva Kassi; Harpal S Randeva
Journal:  Curr Obes Rep       Date:  2021-03-22

3.  An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.

Authors:  Douglas K Brubaker; Manu P Kumar; Evan L Chiswick; Cecil Gregg; Alina Starchenko; Paige N Vega; Austin N Southard-Smith; Alan J Simmons; Elizabeth A Scoville; Lori A Coburn; Keith T Wilson; Ken S Lau; Douglas A Lauffenburger
Journal:  Sci Signal       Date:  2020-08-04       Impact factor: 8.192

Review 4.  Cancer systems immunology.

Authors:  Nathan E Reticker-Flynn; Edgar G Engleman
Journal:  Elife       Date:  2020-07-13       Impact factor: 8.140

Review 5.  Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.

Authors:  Mark C Blaser; Simon Kraler; Thomas F Lüscher; Elena Aikawa
Journal:  Circ Res       Date:  2021-04-29       Impact factor: 17.367

Review 6.  Facing the urgency of therapies for progressive MS - a Progressive MS Alliance proposal.

Authors:  Fernando Dangond; Alexis Donnelly; Reinhard Hohlfeld; Catherine Lubetzki; Susan Kohlhaas; Letizia Leocani; Olga Ciccarelli; Bruno Stankoff; Maria Pia Sormani; Jeremy Chataway; Federico Bozzoli; Francesco Cucca; Lisa Melton; Timothy Coetzee; Marco Salvetti
Journal:  Nat Rev Neurol       Date:  2021-01-22       Impact factor: 42.937

7.  Predicting patient response with models trained on cell lines and patient-derived xenografts by nonlinear transfer learning.

Authors:  Soufiane M C Mourragui; Marco Loog; Daniel J Vis; Kat Moore; Anna G Manjon; Mark A van de Wiel; Marcel J T Reinders; Lodewyk F A Wessels
Journal:  Proc Natl Acad Sci U S A       Date:  2021-12-07       Impact factor: 12.779

8.  Screening for Combination Cancer Therapies With Dynamic Fuzzy Modeling and Multi-Objective Optimization.

Authors:  Simone Spolaor; Martijn Scheve; Murat Firat; Paolo Cazzaniga; Daniela Besozzi; Marco S Nobile
Journal:  Front Genet       Date:  2021-03-31       Impact factor: 4.599

9.  Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study.

Authors:  Andrey V Khrunin; Gennady V Khvorykh; Alexandra V Rozhkova; Evgeniya A Koltsova; Elizaveta A Petrova; Ekaterina I Kimelfeld; Svetlana A Limborska
Journal:  Genes (Basel)       Date:  2021-11-30       Impact factor: 4.096

Review 10.  Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory Therapeutics.

Authors:  Qingliang Yang; Harshani Wijerathne; Jordan C Langston; Mohammad F Kiani; Laurie E Kilpatrick
Journal:  Int J Mol Sci       Date:  2021-07-21       Impact factor: 5.923
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