Literature DB >> 31965983

Phase-separation in chromatin organization.

Geeta J Narlikar1.   

Abstract

The organization of chromatin into different types of compact versus open states provides a means to fine tune gene regulation. Recent studies have suggested a role for phase-separation in chromatin compaction, raising new possibilities for regulating chromatin compartments. This perspective discusses some specific molecular mechanisms that could leverage such phase-separation processes to control the functions and organization of chromatin.

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Year:  2020        PMID： 31965983      PMCID： PMC9107952     

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  14 in total

Review 1.  Heterochromatin: new possibilities for the inheritance of structure.

Authors:  Shiv I S Grewal; Sarah C R Elgin
Journal:  Curr Opin Genet Dev       Date:  2002-04       Impact factor: 5.578

2.  Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome.

Authors:  Yongdae Shin; Yi-Che Chang; Daniel S W Lee; Joel Berry; David W Sanders; Pierre Ronceray; Ned S Wingreen; Mikko Haataja; Clifford P Brangwynne
Journal:  Cell       Date:  2018-11-29       Impact factor: 41.582

3.  Phase separation drives heterochromatin domain formation.

Authors:  Amy R Strom; Alexander V Emelyanov; Mustafa Mir; Dmitry V Fyodorov; Xavier Darzacq; Gary H Karpen
Journal:  Nature       Date:  2017-06-21       Impact factor: 49.962

4.  Preface. New models of the cell nucleus: crowding, entropic forces, phase separation, and fractals.

Authors:  Ronald Hancock; Kwang W Jeon
Journal:  Int Rev Cell Mol Biol       Date:  2014       Impact factor: 6.813

5.  Crystal structure of the nucleosome core particle at 2.8 A resolution.

Authors:  K Luger; A W Mäder; R K Richmond; D F Sargent; T J Richmond
Journal:  Nature       Date:  1997-09-18       Impact factor: 49.962

Review 6.  Mechanisms of functional promiscuity by HP1 proteins.

Authors:  Daniele Canzio; Adam Larson; Geeta J Narlikar
Journal:  Trends Cell Biol       Date:  2014-03-04       Impact factor: 20.808

Review 7.  Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.

Authors:  Simon Alberti; Amy Gladfelter; Tanja Mittag
Journal:  Cell       Date:  2019-01-24       Impact factor: 41.582

Review 8.  Mechanisms of ATP-Dependent Chromatin Remodeling Motors.

Authors:  Coral Y Zhou; Stephanie L Johnson; Nathan I Gamarra; Geeta J Narlikar
Journal:  Annu Rev Biophys       Date:  2016-07-05       Impact factor: 19.763

9.  Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.

Authors:  Adam G Larson; Daniel Elnatan; Madeline M Keenen; Michael J Trnka; Jonathan B Johnston; Alma L Burlingame; David A Agard; Sy Redding; Geeta J Narlikar
Journal:  Nature       Date:  2017-06-21       Impact factor: 49.962

10.  HP1 reshapes nucleosome core to promote phase separation of heterochromatin.

Authors:  S Sanulli; M J Trnka; V Dharmarajan; R W Tibble; B D Pascal; A L Burlingame; P R Griffin; J D Gross; G J Narlikar
Journal:  Nature       Date:  2019-10-16       Impact factor: 49.962
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  15 in total

Review 1.  Protein phase separation: A novel therapy for cancer?

Authors:  Wei Wang; Yingqian Chen; Aixiao Xu; Minyi Cai; Ji Cao; Hong Zhu; Bo Yang; Xuejing Shao; Meidan Ying; Qiaojun He
Journal:  Br J Pharmacol       Date:  2020-09-28       Impact factor: 8.739

2.  Histone H3 and H4 tails play an important role in nucleosome phase separation.

Authors:  Erin F Hammonds; Megan Cleland Harwig; Emeleeta A Paintsil; Emma A Tillison; R Blake Hill; Emma A Morrison
Journal:  Biophys Chem       Date:  2022-02-02       Impact factor: 2.352

Review 3.  The solid and liquid states of chromatin.

Authors:  Jeffrey C Hansen; Kazuhiro Maeshima; Michael J Hendzel
Journal:  Epigenetics Chromatin       Date:  2021-10-30       Impact factor: 4.954

4.  'RNA modulation of transport properties and stability in phase-separated condensates.

Authors:  Andrés R Tejedor; Adiran Garaizar; Jorge Ramírez; Jorge R Espinosa
Journal:  Biophys J       Date:  2021-11-09       Impact factor: 4.033

Review 5.  The spatial organization of transcriptional control.

Authors:  Antonina Hafner; Alistair Boettiger
Journal:  Nat Rev Genet       Date:  2022-09-14       Impact factor: 59.581

6.  Multi-scale phase separation by explosive percolation with single-chromatin loop resolution.

Authors:  Kaustav Sengupta; Michał Denkiewicz; Mateusz Chiliński; Teresa Szczepińska; Ayatullah Faruk Mollah; Sevastianos Korsak; Raissa D'Souza; Yijun Ruan; Dariusz Plewczynski
Journal:  Comput Struct Biotechnol J       Date:  2022-07-02       Impact factor: 6.155

7.  Mammalian nuclear speckles exhibit stable association with chromatin: a biochemical study.

Authors:  Komal Raina; Basuthkar J Rao
Journal:  Nucleus       Date:  2022-12       Impact factor: 4.197

Review 8.  Shining Light on the Dark Side of the Genome.

Authors:  Lori L Wallrath; Felipe Rodriguez-Tirado; Pamela K Geyer
Journal:  Cells       Date:  2022-01-19       Impact factor: 6.600

Review 9.  The road ahead in genetics and genomics.

Authors:  Amy L McGuire; Stacey Gabriel; Sarah A Tishkoff; Ambroise Wonkam; Aravinda Chakravarti; Eileen E M Furlong; Barbara Treutlein; Alexander Meissner; Howard Y Chang; Núria López-Bigas; Eran Segal; Jin-Soo Kim
Journal:  Nat Rev Genet       Date:  2020-08-24       Impact factor: 53.242

10.  Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sites.

Authors:  Mariel Mendoza; Gabor Egervari; Simone Sidoli; Greg Donahue; Desi C Alexander; Payel Sen; Benjamin A Garcia; Shelley L Berger
Journal:  Sci Adv       Date:  2022-01-21       Impact factor: 14.957
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