Carmelo Messina1,2, Luca Petruccio Piodi3, Luca Rinaudo4, Ciriaco Buonomenna5, Luca Maria Sconfienza1,2, Laura Vergani6, Fabio Massimo Ulivieri7. 1. IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy. 2. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Pascal, 36, 20100, Milan, Italy. 3. Gastroenterologia ed Endoscopia Digestiva, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy. 4. TECHNOLOGIC Srl, Lungo Dora Voghera 34/36, 10153, Turin, Italy. 5. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, Via Festa del Perdono 7, 20122, Milan, Italy. 6. Dipartimento di Ingegneria Meccanica, Politecnico di Milano, Via Giuseppe La Masa 1, 20156, Milan, Italy. 7. Medicina Nucleare, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy. ulivieri@gmail.com.
Abstract
OBJECTIVES: Bone strain index (BSI) is a dual-energy X-ray absorptiometry (DXA)-derived index of bone strength obtained from lumbar densitometric scan. We estimated the reproducibility of BSI in healthy women with different body mass index. METHODS: We enrolled postmenopausal women (mean age ± SD: 66 ± 10 years) divided into three groups (A, B and C) according to body mass index (BMI: < 25; 25-29.9; ≥ 30 kg/m2) and two groups (D and E) according to waist circumference (WC: ≤ 88; > 88 cm), each of 30 subjects. They underwent two DXA examinations with in-between repositioning, according to the International Society for Clinical Densitometry guidelines for precision estimation. Bone mineral density (BMD) and BSI were expressed as g/cm2 and absolute value, respectively. The coefficient of variation (CoV) was calculated as the ratio between root-mean-square standard deviation and mean; least significant change percentage (LSC%) as 2.77 × CoV; reproducibility as the complement to 100% LSC. RESULTS: BSI increased proportionally to BMI and WC and significantly in group C compared to B and A (p = 0.032 and 0.006, respectively). BSI was significantly higher in E compared to D (p = 0.017), whereas no differences were observed in BMD. Although BSI reproducibility was slightly lower in group C (89%), the differences were not significant between all groups. BMD reproducibility did not significantly differ between all groups. CONCLUSIONS: BSI reproducibility was significantly lower than that of BMD and decreased proportionally to BMI and WC increase. This reduction of BSI reproducibility was more pronounced in patients with BMI ≥ 30 and WC > 88, as expected, being BSI a parameter sensible to weight.
OBJECTIVES: Bone strain index (BSI) is a dual-energy X-ray absorptiometry (DXA)-derived index of bone strength obtained from lumbar densitometric scan. We estimated the reproducibility of BSI in healthy women with different body mass index. METHODS: We enrolled postmenopausal women (mean age ± SD: 66 ± 10 years) divided into three groups (A, B and C) according to body mass index (BMI: < 25; 25-29.9; ≥ 30 kg/m2) and two groups (D and E) according to waist circumference (WC: ≤ 88; > 88 cm), each of 30 subjects. They underwent two DXA examinations with in-between repositioning, according to the International Society for Clinical Densitometry guidelines for precision estimation. Bone mineral density (BMD) and BSI were expressed as g/cm2 and absolute value, respectively. The coefficient of variation (CoV) was calculated as the ratio between root-mean-square standard deviation and mean; least significant change percentage (LSC%) as 2.77 × CoV; reproducibility as the complement to 100% LSC. RESULTS: BSI increased proportionally to BMI and WC and significantly in group C compared to B and A (p = 0.032 and 0.006, respectively). BSI was significantly higher in E compared to D (p = 0.017), whereas no differences were observed in BMD. Although BSI reproducibility was slightly lower in group C (89%), the differences were not significant between all groups. BMD reproducibility did not significantly differ between all groups. CONCLUSIONS: BSI reproducibility was significantly lower than that of BMD and decreased proportionally to BMI and WC increase. This reduction of BSI reproducibility was more pronounced in patients with BMI ≥ 30 and WC > 88, as expected, being BSI a parameter sensible to weight.
Entities:
Keywords:
Bone mineral density; Bone strain index; Dual-energy X-ray absorptiometry; Osteoporosis; Reproducibility
Authors: Giulia Rodari; G Scuvera; F M Ulivieri; E Profka; F Menni; V Saletti; S Esposito; S Bergamaschi; E Ferrante; C Eller-Vainicher; S Esposito; M Arosio; C Giavoli Journal: Arch Osteoporos Date: 2018-08-27 Impact factor: 2.617
Authors: J A Kanis; D Hans; C Cooper; S Baim; J P Bilezikian; N Binkley; J A Cauley; J E Compston; B Dawson-Hughes; G El-Hajj Fuleihan; H Johansson; W D Leslie; E M Lewiecki; M Luckey; A Oden; S E Papapoulos; C Poiana; R Rizzoli; D A Wahl; E V McCloskey Journal: Osteoporos Int Date: 2011-07-21 Impact factor: 4.507
Authors: Fabio M Ulivieri; Luca P Piodi; Enzo Grossi; Luca Rinaudo; Carmelo Messina; Anna P Tassi; Marcello Filopanti; Anna Tirelli; Francesco Sardanelli Journal: PLoS One Date: 2018-01-05 Impact factor: 3.240
Authors: C Messina; L P Piodi; L Rinaudo; I Emili; F Porro; C Buonomenna; L M Sconfienza; L Vergani; F M Ulivieri Journal: Eur Radiol Exp Date: 2019-08-14