Shuichiro Aoki1, Yoshiaki Kiuchi2, Kana Tokumo2, Yuri Fujino3,4, Masato Matsuura3,4, Hiroshi Murata3, Shunsuke Nakakura5, Ryo Asaoka6. 1. Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan. 2. Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan. 3. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. 4. Department of Rehabilitation, Orthopic and Visual Science, School of Allied Health Sciences, Kitasato University, Tokyo, Kanagawa, Japan. 5. Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Hyogo, Japan. 6. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. rasaoka-tky@umin.ac.jp.
Abstract
PURPOSES: To investigate associations between Corvis ST-measured corneal biomechanical parameters and glaucomatous optic nerve head (ONH) morphology. METHODS: In total, 118 eyes of 70 patients with open-angle glaucoma were examined in this retrospective cross-sectional study. We measured Heidelberg retina tomograph and Corvis ST values in all eyes. We used the linear mixed model in four sectors (temporal superior, TS; temporal inferior, TI; nasal superior, NS; and nasal inferior, NI) to detect associations between six ONH-related parameters and 14 Corvis ST-related parameters, controlling for age, intraocular pressure, axial length, and central corneal thickness. We calculated the ONH temporal and nasal sector vertical asymmetries (TS-TI and NS-NI asymmetries) and identified the optimal linear mixed models to describe them using model selection with the second-order bias corrected Akaike Information Criterion. RESULTS: The Corvis ST A2 velocity was negatively associated with the rim volume in the NS sector (p < 0.05). The optimal model for TS-TI asymmetry was TS-TI asymmetry = - 3.22 + 0.15 × HC time + 0.88 × HC deflection amplitude, whereas that for NS-NI asymmetry was 0.49-0.048 × axial length - 2.45 × A2 velocity. CONCLUSION: Glaucomatous ONH superior-inferior asymmetries were associated with biomechanical properties measured with Corvis ST. Eyes with superior-dominant rim volume reduction of ONH were associated with small deformations and slow recovery of the cornea.
PURPOSES: To investigate associations between Corvis ST-measured corneal biomechanical parameters and glaucomatous optic nerve head (ONH) morphology. METHODS: In total, 118 eyes of 70 patients with open-angle glaucoma were examined in this retrospective cross-sectional study. We measured Heidelberg retina tomograph and Corvis ST values in all eyes. We used the linear mixed model in four sectors (temporal superior, TS; temporal inferior, TI; nasal superior, NS; and nasal inferior, NI) to detect associations between six ONH-related parameters and 14 Corvis ST-related parameters, controlling for age, intraocular pressure, axial length, and central corneal thickness. We calculated the ONH temporal and nasal sector vertical asymmetries (TS-TI and NS-NI asymmetries) and identified the optimal linear mixed models to describe them using model selection with the second-order bias corrected Akaike Information Criterion. RESULTS: The Corvis ST A2 velocity was negatively associated with the rim volume in the NS sector (p < 0.05). The optimal model for TS-TI asymmetry was TS-TI asymmetry = - 3.22 + 0.15 × HC time + 0.88 × HC deflection amplitude, whereas that for NS-NI asymmetry was 0.49-0.048 × axial length - 2.45 × A2 velocity. CONCLUSION:Glaucomatous ONH superior-inferior asymmetries were associated with biomechanical properties measured with Corvis ST. Eyes with superior-dominant rim volume reduction of ONH were associated with small deformations and slow recovery of the cornea.
Entities:
Keywords:
Biomechanics; Glaucoma; Optic nerve head; Visual field
Authors: David F Garway-Heath; David P Crabb; Catey Bunce; Gerassimos Lascaratos; Francesca Amalfitano; Nitin Anand; Augusto Azuara-Blanco; Rupert R Bourne; David C Broadway; Ian A Cunliffe; Jeremy P Diamond; Scott G Fraser; Tuan A Ho; Keith R Martin; Andrew I McNaught; Anil Negi; Krishna Patel; Richard A Russell; Ameet Shah; Paul G Spry; Katsuyoshi Suzuki; Edward T White; Richard P Wormald; Wen Xing; Thierry G Zeyen Journal: Lancet Date: 2014-12-19 Impact factor: 79.321
Authors: Anthony P Wells; David F Garway-Heath; Ali Poostchi; Tracey Wong; Kenneth C Y Chan; Nisha Sachdev Journal: Invest Ophthalmol Vis Sci Date: 2008-03-03 Impact factor: 4.799
Authors: Katie Banister; Charles Boachie; Rupert Bourne; Jonathan Cook; Jennifer M Burr; Craig Ramsay; David Garway-Heath; Joanne Gray; Peter McMeekin; Rodolfo Hernández; Augusto Azuara-Blanco Journal: Ophthalmology Date: 2016-03-23 Impact factor: 12.079