Maria José Rosa1, Terryl J Hartman2, Margaret Adgent3, Kourtney Gardner4, Tebeb Gebretsadik5, Paul E Moore6, Robert L Davis7, Kaja Z LeWinn8, Nicole R Bush9, Frances Tylavsky10, Rosalind J Wright11, Kecia N Carroll3. 1. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: maria.rosa@mssm.edu. 2. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Ga. 3. Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn. 4. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn. 5. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tenn. 6. Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn. 7. Center for Biomedical Informatics, University of Tennessee Health Sciences Center, Memphis, Tenn. 8. Department of Psychiatry, Weill Institute for the Neurosciences, University of California San Francisco, San Francisco, Calif. 9. Department of Psychiatry, Weill Institute for the Neurosciences, University of California San Francisco, San Francisco, Calif; Department of Pediatrics, University of California San Francisco, San Francisco, Calif. 10. Department of Preventive Medicine, University of Tennessee Health Science Center in Memphis, Memphis, Tenn. 11. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Abstract
BACKGROUND: Findings on prenatal polyunsaturated fatty acid (PUFA) intake and child wheeze and asthma have been inconsistent. OBJECTIVE: We sought to examine associations between prenatal PUFA status and child wheeze/asthma and modifying effects of maternal asthma/atopy, child sex, and maternal race. METHODS: Analyses included 1019 mother-child dyads with omega-3 (n-3) and omega-3 (n-6) PUFAs measured in second-trimester plasma; n-6/n-3 ratios were calculated. Child wheeze/asthma outcomes ascertained at age 4 to 6 years included ever physician-diagnosed asthma, current wheeze (symptoms past 12 months), current asthma (diagnosis and medication and/or symptoms past 12 months), and current diagnosed asthma. Each PUFA indicator and outcome was analyzed in separate models using modified Poisson regression with interaction terms. RESULTS: In quartile (Q) analyses, higher n-6 PUFAs were associated with increased risk of ever (risk ratio [RR] high vs low [RR Q4 vs Q1], 1.70; 95% CI, 1.07-2.71) and current (RR Q4 vs Q1, 1.70; 95% CI, 1.07-2.71) diagnosed asthma, whereas n-3 PUFAs were associated with lower risk (RR Q4 vs Q1, 0.59; 95% CI, 0.33-1.03) of current diagnosed asthma (Ptrend < .05 for all). Higher n-6 PUFAs were associated with a higher risk of all respiratory outcomes among children born to women with asthma (Pinteraction < .05 for all outcomes). A significant 3-way interaction between child sex, maternal asthma, and n-6/n-3 PUFA indicated that male children born to women with asthma and a higher ratio had the highest risk across wheeze/asthma outcomes (Pinteraction < .05). CONCLUSIONS: Associations between prenatal PUFA status and childhood wheeze/asthma were modified by maternal history of asthma and child sex.
BACKGROUND: Findings on prenatal polyunsaturated fatty acid (PUFA) intake and child wheeze and asthma have been inconsistent. OBJECTIVE: We sought to examine associations between prenatal PUFA status and child wheeze/asthma and modifying effects of maternal asthma/atopy, child sex, and maternal race. METHODS: Analyses included 1019 mother-child dyads with omega-3 (n-3) and omega-3 (n-6) PUFAs measured in second-trimester plasma; n-6/n-3 ratios were calculated. Child wheeze/asthma outcomes ascertained at age 4 to 6 years included ever physician-diagnosed asthma, current wheeze (symptoms past 12 months), current asthma (diagnosis and medication and/or symptoms past 12 months), and current diagnosed asthma. Each PUFA indicator and outcome was analyzed in separate models using modified Poisson regression with interaction terms. RESULTS: In quartile (Q) analyses, higher n-6 PUFAs were associated with increased risk of ever (risk ratio [RR] high vs low [RR Q4 vs Q1], 1.70; 95% CI, 1.07-2.71) and current (RR Q4 vs Q1, 1.70; 95% CI, 1.07-2.71) diagnosed asthma, whereas n-3 PUFAs were associated with lower risk (RR Q4 vs Q1, 0.59; 95% CI, 0.33-1.03) of current diagnosed asthma (Ptrend < .05 for all). Higher n-6 PUFAs were associated with a higher risk of all respiratory outcomes among children born to women with asthma (Pinteraction < .05 for all outcomes). A significant 3-way interaction between child sex, maternal asthma, and n-6/n-3 PUFA indicated that male children born to women with asthma and a higher ratio had the highest risk across wheeze/asthma outcomes (Pinteraction < .05). CONCLUSIONS: Associations between prenatal PUFA status and childhood wheeze/asthma were modified by maternal history of asthma and child sex.
Authors: Bright I Nwaru; Maijaliisa Erkkola; Mirka Lumia; Carina Kronberg-Kippilä; Suvi Ahonen; Minna Kaila; Jorma Ilonen; Olli Simell; Mikael Knip; Riitta Veijola; Suvi M Virtanen Journal: Br J Nutr Date: 2011-11-09 Impact factor: 3.718
Authors: Tanya L Blasbalg; Joseph R Hibbeln; Christopher E Ramsden; Sharon F Majchrzak; Robert R Rawlings Journal: Am J Clin Nutr Date: 2011-03-02 Impact factor: 7.045
Authors: Roger B Newson; Seif O Shaheen; A John Henderson; Pauline M Emmett; Andrea Sherriff; Philip C Calder Journal: J Allergy Clin Immunol Date: 2004-09 Impact factor: 10.793
Authors: Keadrea Wilson; Tebeb Gebretsadik; Margaret A Adgent; Christine Loftus; Catherine Karr; Paul E Moore; Sheela Sathyanarayana; Nora Byington; Emily Barrett; Nicole Bush; Ruby Nguyen; Terry J Hartman; Kaja Z LeWinn; Alexis Calvert; W Alex Mason; Kecia N Carroll Journal: Ann Allergy Asthma Immunol Date: 2022-05-10 Impact factor: 6.248
Authors: Marnie F Hazlehurst; Kecia N Carroll; Christine T Loftus; Adam A Szpiro; Paul E Moore; Joel D Kaufman; Kipruto Kirwa; Kaja Z LeWinn; Nicole R Bush; Sheela Sathyanarayana; Frances A Tylavsky; Emily S Barrett; Ruby H N Nguyen; Catherine J Karr Journal: Environ Epidemiol Date: 2021-04
Authors: Matthias V Kopp; Cathleen Muche-Borowski; Michael Abou-Dakn; Birgit Ahrens; Kirsten Beyer; Katharina Blümchen; Petra Bubel; Adam Chaker; Monika Cremer; Regina Ensenauer; Michael Gerstlauer; Uwe Gieler; Inga-Marie Hübner; Fritz Horak; Ludger Klimek; Berthold V Koletzko; Sybille Koletzko; Susanne Lau; Thomas Lob-Corzilius; Katja Nemat; Eva M J Peters; Antonio Pizzulli; Imke Reese; Claudia Rolinck-Werninghaus; Elien Rouw; Bianca Schaub; Sebastian Schmidt; Jens-Oliver Steiß; Anne Kathrin Striegel; Zsolt Szépfalusi; Dietmar Schlembach; Thomas Spindler; Christian Taube; Valérie Trendelenburg; Regina Treudler; Ulrich Umpfenbach; Christian Vogelberg; Martin Wagenmann; Anke Weißenborn; Thomas Werfel; Margitta Worm; Helmut Sitter; Eckard Hamelmann Journal: Allergol Select Date: 2022-03-04