BACKGROUND: Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease. OBJECTIVE: To assess prenatal fatty acid exposures as predictors of early childhood wheezing and eczema. METHODS: In the Avon Longitudinal Study of Parents and Children, late pregnancy maternal blood samples and umbilical cord blood samples were assayed for n-6 and n-3 fatty acids (percentage of total red cell phospholipid), and mothers were asked about wheezing and eczema in their children. We measured associations of 11 n-6 and n-3 fatty acid exposures with wheezing at 30 to 42 months, with wheezing patterns defined by presence (+) or absence (-) of wheezing during 2 periods, 0 to 6 months and 30 to 42 months (transient infant, +/-; later-onset, -/+; persistent, +/+; n=1191 and n=2764 for cord and maternal analyses, respectively), and with eczema at 18 to 30 months (n=1238 and n=2945 for cord and maternal analyses, respectively). RESULTS: In cord blood red cells, the ratio of arachidonic:eicosapentaenoic acid was positively associated with eczema (adjusted odds ratio [OR] per doubling, 1.14; 95% CI, 1.00-1.31; P=.044), the ratio of linoleic acid:alpha-linolenic acid was positively associated with later-onset wheeze (OR, 1.30; CI, 1.04-1.61; P=.019), and the ratio of alpha-linolenic acid:n-3 products was negatively associated with later-onset wheeze (OR, 0.86; CI, 0.75-0.99; P=.040). However, these associations were no longer significant after adjusting for multiple comparisons. CONCLUSIONS: It seems unlikely that fetal exposure to n-6 and n-3 fatty acids is an important determinant of early childhood wheezing and atopic disease.
BACKGROUND: Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease. OBJECTIVE: To assess prenatal fatty acid exposures as predictors of early childhood wheezing and eczema. METHODS: In the Avon Longitudinal Study of Parents and Children, late pregnancy maternal blood samples and umbilical cord blood samples were assayed for n-6 and n-3 fatty acids (percentage of total red cell phospholipid), and mothers were asked about wheezing and eczema in their children. We measured associations of 11 n-6 and n-3 fatty acid exposures with wheezing at 30 to 42 months, with wheezing patterns defined by presence (+) or absence (-) of wheezing during 2 periods, 0 to 6 months and 30 to 42 months (transient infant, +/-; later-onset, -/+; persistent, +/+; n=1191 and n=2764 for cord and maternal analyses, respectively), and with eczema at 18 to 30 months (n=1238 and n=2945 for cord and maternal analyses, respectively). RESULTS: In cord blood red cells, the ratio of arachidonic:eicosapentaenoic acid was positively associated with eczema (adjusted odds ratio [OR] per doubling, 1.14; 95% CI, 1.00-1.31; P=.044), the ratio of linoleic acid:alpha-linolenic acid was positively associated with later-onset wheeze (OR, 1.30; CI, 1.04-1.61; P=.019), and the ratio of alpha-linolenic acid:n-3 products was negatively associated with later-onset wheeze (OR, 0.86; CI, 0.75-0.99; P=.040). However, these associations were no longer significant after adjusting for multiple comparisons. CONCLUSIONS: It seems unlikely that fetal exposure to n-6 and n-3 fatty acids is an important determinant of early childhood wheezing and atopic disease.
Authors: Diane R Gold; Ben M Willwerth; Kelan G Tantisira; Patricia W Finn; Bianca Schaub; David L Perkins; Arthur Tzianabos; Ngoc P Ly; Christian Schroeter; Fiona Gibbons; Hannia Campos; Emily Oken; Matthew W Gillman; Lyle J Palmer; Louise M Ryan; Scott T Weiss Journal: J Allergy Clin Immunol Date: 2006-02-14 Impact factor: 10.793
Authors: Nikos Stratakis; Theano Roumeliotaki; Emily Oken; Ferran Ballester; Henrique Barros; Mikel Basterrechea; Sylvaine Cordier; Renate de Groot; Herman T den Dekker; Liesbeth Duijts; Merete Eggesbø; Maria Pia Fantini; Francesco Forastiere; Ulrike Gehring; Marij Gielen; Davide Gori; Eva Govarts; Hazel M Inskip; Nina Iszatt; Maria Jansen; Cecily Kelleher; John Mehegan; Carolina Moltó-Puigmartí; Monique Mommers; Andreia Oliveira; Sjurdur F Olsen; Fabienne Pelé; Costanza Pizzi; Daniela Porta; Lorenzo Richiardi; Sheryl L Rifas-Shiman; Sian M Robinson; Greet Schoeters; Marin Strøm; Jordi Sunyer; Carel Thijs; Martine Vrijheid; Tanja G M Vrijkotte; Alet H Wijga; Manolis Kogevinas; Maurice P Zeegers; Leda Chatzi Journal: Int J Epidemiol Date: 2017-10-01 Impact factor: 7.196
Authors: Maria José Rosa; Terryl J Hartman; Margaret Adgent; Kourtney Gardner; Tebeb Gebretsadik; Paul E Moore; Robert L Davis; Kaja Z LeWinn; Nicole R Bush; Frances Tylavsky; Rosalind J Wright; Kecia N Carroll Journal: J Allergy Clin Immunol Date: 2019-12-03 Impact factor: 10.793