Margaret A Adgent1,2, Tebeb Gebretsadik3, Jada Reedus1,4, Cornelia Graves5, Etoi Garrison6, Nicole Bush7,8, Robert Davis9, Kaja Z LeWinn7, Frances Tylavsky10, Kecia N Carroll1. 1. Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. 2. Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA. 3. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. 4. Meharry Medical College, Nashville, TN, USA. 5. University of Tennessee Health Sciences Center, College of Medicine, Nashville and Tennessee Maternal Fetal Medicine, Nashville, TN, USA. 6. Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA. 7. Department of Psychiatry, University of California, San Francisco, CA, USA. 8. Department of Pediatrics, University of California, San Francisco, CA, USA. 9. Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, USA. 10. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Abstract
BACKGROUND: Childhood asthma is a common chronic disease that likely has prenatal origins. Gestational diabetes alters maternal physiology and may influence fetal risk for childhood-onset disease. However, the association between gestational diabetes and child asthma is not well characterized. OBJECTIVE: To investigate the association between gestational diabetes and wheeze/asthma at approximately 4 years of age in a racially diverse US cohort. METHODS: We studied mother-child dyads enrolled prenatally in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. Gestational diabetes was determined by medical chart review. At approximately 4 years of age, we assessed child respiratory outcomes including parent report of physician-diagnosed asthma (ever), current wheeze (symptoms within the past 12 months), and current asthma (physician diagnosis and/or medication or symptoms within the past 12 months). We used the modified Poisson regression to assess associations between gestational diabetes and child respiratory outcomes, adjusting for maternal age, race, prenatal smoking, pre-pregnancy body mass index, parity, asthma history, socioeconomic status, and infant sex. RESULTS: Among 1107 women, 66% were African American/Black. Six percent (n = 62) had gestational diabetes documented during pregnancy. Gestational diabetes was associated with increased risk of physician-diagnosed asthma (adjusted risk ratio (RR) [95% Confidence Interval]: 2.13 [1.35, 3.38]; prevalence: 14%), current wheeze (RR: 1.85 [1.23, 2.78]; prevalence: 19%), and current asthma (RR: 2.01 [1.30, 3.10]; prevalence: 16%). CONCLUSIONS: Gestational diabetes was associated with increased risk of asthma and wheeze outcomes. Additional studies are needed to elucidate modifiable pathways underlying this association.
BACKGROUND: Childhood asthma is a common chronic disease that likely has prenatal origins. Gestational diabetes alters maternal physiology and may influence fetal risk for childhood-onset disease. However, the association between gestational diabetes and child asthma is not well characterized. OBJECTIVE: To investigate the association between gestational diabetes and wheeze/asthma at approximately 4 years of age in a racially diverse US cohort. METHODS: We studied mother-child dyads enrolled prenatally in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. Gestational diabetes was determined by medical chart review. At approximately 4 years of age, we assessed child respiratory outcomes including parent report of physician-diagnosed asthma (ever), current wheeze (symptoms within the past 12 months), and current asthma (physician diagnosis and/or medication or symptoms within the past 12 months). We used the modified Poisson regression to assess associations between gestational diabetes and child respiratory outcomes, adjusting for maternal age, race, prenatal smoking, pre-pregnancy body mass index, parity, asthma history, socioeconomic status, and infant sex. RESULTS: Among 1107 women, 66% were African American/Black. Six percent (n = 62) had gestational diabetes documented during pregnancy. Gestational diabetes was associated with increased risk of physician-diagnosed asthma (adjusted risk ratio (RR) [95% Confidence Interval]: 2.13 [1.35, 3.38]; prevalence: 14%), current wheeze (RR: 1.85 [1.23, 2.78]; prevalence: 19%), and current asthma (RR: 2.01 [1.30, 3.10]; prevalence: 16%). CONCLUSIONS: Gestational diabetes was associated with increased risk of asthma and wheeze outcomes. Additional studies are needed to elucidate modifiable pathways underlying this association.
Authors: Maria José Rosa; Terryl J Hartman; Margaret Adgent; Kourtney Gardner; Tebeb Gebretsadik; Paul E Moore; Robert L Davis; Kaja Z LeWinn; Nicole R Bush; Frances Tylavsky; Rosalind J Wright; Kecia N Carroll Journal: J Allergy Clin Immunol Date: 2019-12-03 Impact factor: 10.793
Authors: Paul S Noakes; Richard Thomas; Catherine Lane; Trevor A Mori; Anne E Barden; Sunalene G Devadason; Susan L Prescott Journal: Thorax Date: 2007-03-13 Impact factor: 9.139
Authors: Margaret A Adgent; Tebeb Gebretsadik; Cordelia R Elaiho; Ginger L Milne; Paul Moore; Terryl J Hartman; Whitney Cowell; Cecilia S Alcala; Nicole Bush; Robert Davis; Kaja Z LeWinn; Frances A Tylavsky; Rosalind J Wright; Kecia N Carroll Journal: Free Radic Biol Med Date: 2022-07-19 Impact factor: 8.101