Literature DB >> 31765515

Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.

Wai Ling Cheung-Lee1, Madison E Parry1, Chuhan Zong2, Alexis Jaramillo Cartagena3, Seth A Darst3, Nancy D Connell4, Riccardo Russo5, A James Link1,2,6.   

Abstract

We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides, with 18 of its 28 amino acids found in the mechanically bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans, causative agents of lung infections in cystic fibrosis patients.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RiPP; antibiotics; lasso peptides; natural products; peptides

Year:  2020        PMID： 31765515      PMCID： PMC7205569          DOI： 10.1002/cbic.201900707

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  36 in total

Review 1.  Lasso peptides: an intriguing class of bacterial natural products.

Authors:  Julian D Hegemann; Marcel Zimmermann; Xiulan Xie; Mohamed A Marahiel
Journal:  Acc Chem Res       Date:  2015-06-16       Impact factor: 22.384

Review 2.  Lasso peptides: structure, function, biosynthesis, and engineering.

Authors:  Mikhail O Maksimov; Si Jia Pan; A James Link
Journal:  Nat Prod Rep       Date:  2012-07-25       Impact factor: 13.423

3.  The FhuA protein is involved in microcin 25 uptake.

Authors:  R A Salomón; R N Farías
Journal:  J Bacteriol       Date:  1993-12       Impact factor: 3.490

4.  The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase.

Authors:  Konstantin Kuznedelov; Ekaterina Semenova; Thomas A Knappe; Damir Mukhamedyarov; Aashish Srivastava; Sujoy Chatterjee; Richard H Ebright; Mohamed A Marahiel; Konstantin Severinov
Journal:  J Mol Biol       Date:  2011-03-15       Impact factor: 5.469

5.  Systematic structure-activity analysis of microcin J25.

Authors:  Olga Pavlova; Jayanta Mukhopadhyay; Elena Sineva; Richard H Ebright; Konstantin Severinov
Journal:  J Biol Chem       Date:  2008-07-16       Impact factor: 5.157

6.  Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail.

Authors:  Kelly-Anne Wilson; Markus Kalkum; Jennifer Ottesen; Julia Yuzenkova; Brian T Chait; Robert Landick; Tom Muir; Konstantin Severinov; Seth A Darst
Journal:  J Am Chem Soc       Date:  2003-10-15       Impact factor: 15.419

7.  Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.

Authors:  Jayanta Mukhopadhyay; Elena Sineva; Jennifer Knight; Ronald M Levy; Richard H Ebright
Journal:  Mol Cell       Date:  2004-06-18       Impact factor: 17.970

Review 8.  Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Authors:  Paul G Arnison; Mervyn J Bibb; Gabriele Bierbaum; Albert A Bowers; Tim S Bugni; Grzegorz Bulaj; Julio A Camarero; Dominic J Campopiano; Gregory L Challis; Jon Clardy; Paul D Cotter; David J Craik; Michael Dawson; Elke Dittmann; Stefano Donadio; Pieter C Dorrestein; Karl-Dieter Entian; Michael A Fischbach; John S Garavelli; Ulf Göransson; Christian W Gruber; Daniel H Haft; Thomas K Hemscheidt; Christian Hertweck; Colin Hill; Alexander R Horswill; Marcel Jaspars; Wendy L Kelly; Judith P Klinman; Oscar P Kuipers; A James Link; Wen Liu; Mohamed A Marahiel; Douglas A Mitchell; Gert N Moll; Bradley S Moore; Rolf Müller; Satish K Nair; Ingolf F Nes; Gillian E Norris; Baldomero M Olivera; Hiroyasu Onaka; Mark L Patchett; Joern Piel; Martin J T Reaney; Sylvie Rebuffat; R Paul Ross; Hans-Georg Sahl; Eric W Schmidt; Michael E Selsted; Konstantin Severinov; Ben Shen; Kaarina Sivonen; Leif Smith; Torsten Stein; Roderich D Süssmuth; John R Tagg; Gong-Li Tang; Andrew W Truman; John C Vederas; Christopher T Walsh; Jonathan D Walton; Silke C Wenzel; Joanne M Willey; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2013-01       Impact factor: 13.423

9.  A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.

Authors:  Julio Diaz Caballero; Shawn T Clark; Pauline W Wang; Sylva L Donaldson; Bryan Coburn; D Elizabeth Tullis; Yvonne C W Yau; Valerie J Waters; David M Hwang; David S Guttman
Journal:  PLoS Pathog       Date:  2018-12-07       Impact factor: 6.823

10.  Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides.

Authors:  Indran Mathavan; Séverine Zirah; Shahid Mehmood; Hassanul G Choudhury; Christophe Goulard; Yanyan Li; Carol V Robinson; Sylvie Rebuffat; Konstantinos Beis
Journal:  Nat Chem Biol       Date:  2014-04-06       Impact factor: 15.040
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  7 in total

Review 1.  How to harness biosynthetic gene clusters of lasso peptides.

Authors:  Shinya Kodani; Kohta Unno
Journal:  J Ind Microbiol Biotechnol       Date:  2020-07-23       Impact factor: 3.346

2.  Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in Burkholderia.

Authors:  Truc Do; Alina Thokkadam; Robert Leach; A James Link
Journal:  ACS Chem Biol       Date:  2022-07-08       Impact factor: 4.634

3.  Streptomyces griseocarneus R132 expresses antimicrobial genes and produces metabolites that modulate Galleria mellonella immune system.

Authors:  Kátia Aparecida de Siqueira; Rhavena Graziela Liotti; Janaina Rosa de Sousa; Suzana Junges Vendruscullo; Gilza Barcelos de Souza; Leonardo Gomes de Vasconcelos; Ana Helena Januário; Tiago Antônio de Oliveira Mendes; Marcos Antônio Soares
Journal:  3 Biotech       Date:  2021-08-04       Impact factor: 2.893

4.  Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs).

Authors:  Truc Do; A James Link
Journal:  Biochemistry       Date:  2022-01-10       Impact factor: 3.321

5.  Biosynthesis of Ditropolonyl Sulfide, an Antibacterial Compound Produced by Burkholderia cepacia Complex Strain R-12632.

Authors:  Eliza Depoorter; Tom Coenye; Peter Vandamme
Journal:  Appl Environ Microbiol       Date:  2021-09-15       Impact factor: 4.792

6.  BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression.

Authors:  Miao Dong; Shu Hin Kwok; Joseph L Humble; Yimin Liang; Sze Wing Tang; Kin Hung Tang; Man Kit Tse; Josh Haipeng Lei; Rajkumar Ramalingam; Mohamad Koohi-Moghadam; Doris Wai Ting Au; Hongyan Sun; Yun Wah Lam
Journal:  Sci Rep       Date:  2021-06-09       Impact factor: 4.379

7.  Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification.

Authors:  Li Cao; Moshe Beiser; Joseph D Koos; Margarita Orlova; Hader E Elashal; Hendrik V Schröder; A James Link
Journal:  J Am Chem Soc       Date:  2021-07-20       Impact factor: 16.383
  7 in total

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