PURPOSE: To determine the incidence of open-angle glaucoma (OAG) in Melbourne, Victoria, Australia. DESIGN: Population-based cohort study. PARTICIPANTS: Total of 3271 participants aged 40 years and older from Melbourne, Victoria, Australia. MAIN OUTCOME MEASURES: Five-year incidence of OAG. METHODS: Participants were recruited through a cluster random sampling from nine urban clusters. Baseline examination was conducted from 1992 through 1994, and the follow-up data were collected from 1997 through 1999. Each participant both at baseline and follow-up underwent a standardized ophthalmic examination including intraocular pressure measurement, visual field assessment, cup-to-disc ratio measurement, and paired stereo photographs of the optic disc. Glaucoma was assessed by a consensus group of six ophthalmologists that included two glaucoma specialists. Glaucoma was diagnosed as possible, probable, or definite. RESULTS: The overall incidence of definite OAG was 0.5% (95% confidence limits [CL], 0.3, 0.7); probable and definite incidence of OAG was 1.1% (95% CL, 0.8,1.4); and possible, probable, and definite OAG incidence was 2.7% (95% CL, 1.8, 3.7). The incidence of possible, probable, and definite OAG increases significantly as age increases (P < 0.001). The incidence of definite OAG increases from 0% of participants aged 40 to 49 years to 4.1% of participants aged 80 years and older. The incidence of probable and definite OAG increases from 0.2% of participants aged 40 to 49 years to 5.4% of participants aged 80 years and older. The incidence of possible, probable, and definite OAG increases from 0.5% of participants aged 40 to 49 years to 11% of participants aged 80 years and older. A nonsignificant but higher incidence of definite OAG among men was observed in this study when compared with women (odds ratio, 2.2; 95% CL, 0.9, 5.9). Fifty percent of the definite OAG participants were undiagnosed. CONCLUSIONS: The incidence of OAG increases significantly with age. The undiagnosed cases suggest the need to develop novel community screening strategies for glaucoma.
PURPOSE: To determine the incidence of open-angle glaucoma (OAG) in Melbourne, Victoria, Australia. DESIGN: Population-based cohort study. PARTICIPANTS: Total of 3271 participants aged 40 years and older from Melbourne, Victoria, Australia. MAIN OUTCOME MEASURES: Five-year incidence of OAG. METHODS:Participants were recruited through a cluster random sampling from nine urban clusters. Baseline examination was conducted from 1992 through 1994, and the follow-up data were collected from 1997 through 1999. Each participant both at baseline and follow-up underwent a standardized ophthalmic examination including intraocular pressure measurement, visual field assessment, cup-to-disc ratio measurement, and paired stereo photographs of the optic disc. Glaucoma was assessed by a consensus group of six ophthalmologists that included two glaucoma specialists. Glaucoma was diagnosed as possible, probable, or definite. RESULTS: The overall incidence of definite OAG was 0.5% (95% confidence limits [CL], 0.3, 0.7); probable and definite incidence of OAG was 1.1% (95% CL, 0.8,1.4); and possible, probable, and definite OAG incidence was 2.7% (95% CL, 1.8, 3.7). The incidence of possible, probable, and definite OAG increases significantly as age increases (P < 0.001). The incidence of definite OAG increases from 0% of participants aged 40 to 49 years to 4.1% of participants aged 80 years and older. The incidence of probable and definite OAG increases from 0.2% of participants aged 40 to 49 years to 5.4% of participants aged 80 years and older. The incidence of possible, probable, and definite OAG increases from 0.5% of participants aged 40 to 49 years to 11% of participants aged 80 years and older. A nonsignificant but higher incidence of definite OAG among men was observed in this study when compared with women (odds ratio, 2.2; 95% CL, 0.9, 5.9). Fifty percent of the definite OAG participants were undiagnosed. CONCLUSIONS: The incidence of OAG increases significantly with age. The undiagnosed cases suggest the need to develop novel community screening strategies for glaucoma.
Authors: V C T Sung; J M Koppens; S A Vernon; P Pawson; M Rubinstein; A J King; C L Tattersall Journal: Br J Ophthalmol Date: 2006-01 Impact factor: 4.638
Authors: Janey L Wiggs; Jae Hee Kang; Brian L Yaspan; Daniel B Mirel; Cathy Laurie; Andrew Crenshaw; Wendy Brodeur; Stephanie Gogarten; Lana M Olson; Wael Abdrabou; Elizabeth DelBono; Stephanie Loomis; Jonathan L Haines; Louis R Pasquale Journal: Hum Mol Genet Date: 2011-08-26 Impact factor: 6.150
Authors: Kevin C Chan; Yu Yu; Shuk Han Ng; Heather K Mak; Yolanda W Y Yip; Yolandi van der Merwe; Tianmin Ren; Jasmine S Y Yung; Sayantan Biswas; Xu Cao; Ying Chau; Christopher K S Leung Journal: Acta Biomater Date: 2019-06-06 Impact factor: 8.947