Eleni Kapogianni1, Mike Barbeck2,3, Tim Fienitz4, Daniel Rothamel4,5, Ole Jung1,3, Aylin Arslan3, Lennart Kuhnel1, Xin Xiong6, Rumen Krastev6,7, Reinhard E. Friedrich1, Reinhard Schnettler1. 1. Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany. 2. Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany mike.barbeck@icloud.com. 3. BerlinAnalytix GmbH, Berlin, Germany. 4. Department of Oral and Maxillofacial Plastic Surgery, Evangelic Johanniter Hospital Bethesda Mönchengladbach, Mönchengladbach, Germany. 5. Department of Oral and Maxillofacial Plastic Surgery, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany. 6. Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany. 7. Department of Intelligent Surfaces, Faculty of Applied Chemistry, Reutlingen University, Reutlingen, Germany.
Abstract
BACKGROUND/AIM: The aim of this study was the development of a new osteoconductivity index to determine the bone healing capacities of bone substitute materials (BSM) on the basis of 3D microcomputed tomographic (μ-CT) data. MATERIALS AND METHODS: Sinus biopsies were used for the comparative analysis of the integration behavior of two xenogeneic BSM (cerabone® and Bio-Oss®). 3D μ-CT and data sets from histomorphometrical measurements based on 2D histological slices were used to measure the bone-material-contact and the tissue distribution within the biopsies. The tissue reactions to both BSM were microscopically analyzed. RESULTS: The 3D and 2D results of the osteoconductivity measurements showed comparable material-bone contacts for both BSM, but the 2D data were significantly lower. The same results were found when tissue distribution was measured in both groups. The histopathological analysis showed comparative tissue reactions in both BSM. CONCLUSION: Osteoconductivity index is a reliable measurement parameter for determining the healing capacities of BSM. The observed differences between both measurement methods could be assigned to the resolution capacity of μ-CT data that did not allow for a precise interface distinction between both BSM and bone tissue. Histomorphometrical data based on histological slides still allow for a more exact evaluation. Copyright
BACKGROUND/AIM: The aim of this study was the development of a new osteoconductivity index to determine the bone healing capacities of bone substitute materials (BSM) on the basis of 3D microcomputed tomographic (μ-CT) data. MATERIALS AND METHODS: Sinus biopsies were used for the comparative analysis of the integration behavior of two xenogeneic BSM (cerabone® and Bio-Oss®). 3D μ-CT and data sets from histomorphometrical measurements based on 2D histological slices were used to measure the bone-material-contact and the tissue distribution within the biopsies. The tissue reactions to both BSM were microscopically analyzed. RESULTS: The 3D and 2D results of the osteoconductivity measurements showed comparable material-bone contacts for both BSM, but the 2D data were significantly lower. The same results were found when tissue distribution was measured in both groups. The histopathological analysis showed comparative tissue reactions in both BSM. CONCLUSION: Osteoconductivity index is a reliable measurement parameter for determining the healing capacities of BSM. The observed differences between both measurement methods could be assigned to the resolution capacity of μ-CT data that did not allow for a precise interface distinction between both BSM and bone tissue. Histomorphometrical data based on histological slides still allow for a more exact evaluation. Copyright
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