Literature DB >> 3162224

Multilocus analysis of the fragile X syndrome.

W T Brown1, A Gross, C Chan, E C Jenkins, J L Mandel, I Oberlé, B Arveiler, G Novelli, S Thibodeau, R Hagerman.   

Abstract

A multilocus analysis of the fragile X (fra(X] syndrome was conducted with 147 families. Two proximal loci, DXS51 and F9, and two distal loci, DXS52 and DXS15, were studied. Overall, the best multipoint distances were found to be DXS51-F9, 6.9%, F9-fra(X), 22.4%; fra(X)-DXS52, 12.7%; DXS52-DXS15, 2.2%. These distances can be used for multipoint mapping of new probes, carrier testing and counseling of fra(X) families. Consistent with several previous studies, the families as a whole showed genetic heterogeneity for linkage between F9 and fra(X).

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Year:  1988        PMID： 3162224     DOI： 10.1007/bf00291662

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  29 in total

1.  Evidence against close linkage of the loci for fraXq of Martin-Bell syndrome and for factor IX.

Authors:  B Zoll; J Arnemann; M Krawczak; D N Cooper; G Pescia; W Wahli; P Steinbach; J Schmidtke
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

2.  Linkage studies of X-linked mental retardation: high frequency of recombination in the telomeric region of the human X chromosome (fragile site/linkage/recombination/X chromosome).

Authors:  K E Davies; M G Mattei; J F Mattei; H Veenema; S McGlade; K Harper; N Tommerup; K B Nielsen; M Mikkelsen; P Beighton
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

3.  Genetic heterogeneity of X-linked mental retardation with fragile X. Association of tight linkage to factor IX and incomplete penetrance in males.

Authors:  F Giannelli; A H Morris; C Garrett; M Daker; C Thurston; C A Smith
Journal:  Ann Hum Genet       Date:  1987-05       Impact factor: 1.670

4.  Mapping of DNA markers close to the fragile site on the human X chromosome at Xq27.3.

Authors:  M Patterson; S Kenwrick; S Thibodeau; K Faulk; M G Mattei; J F Mattei; K E Davies
Journal:  Nucleic Acids Res       Date:  1987-03-25       Impact factor: 16.971

5.  The marker (X) syndrome: a cytogenetic and genetic analysis.

Authors:  S L Sherman; N E Morton; P A Jacobs; G Turner
Journal:  Ann Hum Genet       Date:  1984-01       Impact factor: 1.670

6.  Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.

Authors:  D Drayna; K Davies; D Hartley; J L Mandel; G Camerino; R Williamson; R White
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

7.  The genetic linkage map of the human X chromosome.

Authors:  D Drayna; R White
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

8.  Further evidence for genetic heterogeneity in the fragile X syndrome.

Authors:  W T Brown; E C Jenkins; A C Gross; C B Chan; M S Krawczun; C J Duncan; S L Sklower; G S Fisch
Journal:  Hum Genet       Date:  1987-04       Impact factor: 4.132

9.  The fragile X syndrome in a large family. III. Investigations on linkage of flanking DNA markers with the fragile site Xq27.

Authors:  H Veenema; N J Carpenter; E Bakker; M H Hofker; A M Ward; P L Pearson
Journal:  J Med Genet       Date:  1987-07       Impact factor: 6.318

10.  Analysis of fragile X-mental retardation families using flanking polymorphic DNA probes.

Authors:  P Goonewardena; K H Gustavson; G Holmgren; A Tolun; J Chotai; E Johnsen; U Pettersson
Journal:  Clin Genet       Date:  1986-10       Impact factor: 4.438
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  11 in total

1.  Further localization of X-linked hydrocephalus in the chromosomal region Xq28.

Authors:  P J Willems; L Vits; P Raeymaekers; J Beuten; P Coucke; J J Holden; C Van Broeckhoven; S T Warren; M Sagi; D Robinson
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

2.  Genetic mapping of two new DNA markers in Xq26-q28 relative to the fragile-X syndrome locus.

Authors:  R Sood; L M Mulligan; R Poon; B N White; J J Holden
Journal:  Am J Hum Genet       Date:  1990-09       Impact factor: 11.025

Review 3.  The fragile X: progress toward solving the puzzle.

Authors:  W T Brown
Journal:  Am J Hum Genet       Date:  1990-08       Impact factor: 11.025

4.  Physical and genetic mapping of polymorphic loci in Xq28 (DXS15, DXS52, and DXS134): analysis of a cosmid clone and a yeast artificial chromosome.

Authors:  R Feil; G Palmieri; M d'Urso; R Heilig; I Oberlé; J L Mandel
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

5.  Further evidence localising the gene for Hunter's syndrome to the distal region of the X chromosome long arm.

Authors:  S H Roberts; M Upadhyaya; M Sarfarazi; P S Harper
Journal:  J Med Genet       Date:  1989-05       Impact factor: 6.318

6.  Linkage studies in a large fragile X family.

Authors:  M Patterson; M Bell; W Kress; K E Davies; U Froster-Iskenius
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

7.  Genetic mapping of new DNA probes at Xq27 defines a strategy for DNA studies in the fragile X syndrome.

Authors:  G K Suthers; J C Mulley; M A Voelckel; N Dahl; M L Väisänen; P Steinbach; I A Glass; C E Schwartz; B A van Oost; S N Thibodeau
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025

8.  Completion of the physical map of Xq28: the location of the gene for L1CAM on the human X chromosome.

Authors:  A Dietrich; B Korn; A Poustka
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

9.  Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304).

Authors:  N Dahl; P Goonewardena; H Malmgren; K H Gustavson; G Holmgren; E Seemanova; G Annerén; A Flood; U Pettersson
Journal:  Am J Hum Genet       Date:  1989-08       Impact factor: 11.025

10.  Inheritance of the fragile X syndrome: size of the fragile X premutation is a major determinant of the transition to full mutation.

Authors:  D Heitz; D Devys; G Imbert; C Kretz; J L Mandel
Journal:  J Med Genet       Date:  1992-11       Impact factor: 6.318
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