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Literature DB >> 2882476

Mapping of DNA markers close to the fragile site on the human X chromosome at Xq27.3.

M Patterson, S Kenwrick, S Thibodeau, K Faulk, M G Mattei, J F Mattei, K E Davies.

Abstract

We report the identification of a new RFLP detected by the DNA probe MN12, which is linked to both the fragile site on the X chromosome at Xq27.3 and the highly polymorphic locus detected by St14 (DXS52). In situ mapping confirms the localisation of MN12 distal to the fragile site. A detailed physical analysis of this region of the X chromosome using pulsed-field gel electrophoresis has shown that MN12, St14 and DX13 (DXS15) are physically linked within a region of 470kb. A long range restriction map around the MN12 locus reveals at least two candidate HTF islands, suggesting the existence of expressed sequences in this region.

Entities: Chemical Gene Species

Mesh：

Year: 1987 PMID： 2882476 PMCID： PMC340674 DOI： 10.1093/nar/15.6.2639

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

17 in total

1. Long-range restriction site mapping of mammalian genomic DNA.

Authors: W R Brown; A P Bird
Journal: Nature Date: 1986 Jul 31-Aug 6 Impact factor: 49.962

2. Report of the Committee on the Genetic Constitution of the X and Y Chromosomes.

Authors: P N Goodfellow; K E Davies; H H Ropers
Journal: Cytogenet Cell Genet Date: 1985

3. The marker (X) syndrome: a cytogenetic and genetic analysis.

Authors: S L Sherman; N E Morton; P A Jacobs; G Turner
Journal: Ann Hum Genet Date: 1984-01 Impact factor: 1.670

4. Chiasma frequency and distribution in a sample of human males: chromosomes 1, 2, and 9.

Authors: D A Laurie; M Hultén; G H Jones
Journal: Cytogenet Cell Genet Date: 1981

Review 5. Marker (X)-linked mental retardation.

Authors: G Turner; P Jacobs
Journal: Adv Hum Genet Date: 1983

6. Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.

Authors: D Drayna; K Davies; D Hartley; J L Mandel; G Camerino; R Williamson; R White
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

7. Long-range restriction map around the Duchenne muscular dystrophy gene.

Authors: M Burmeister; H Lehrach
Journal: Nature Date: 1986 Dec 11-17 Impact factor: 49.962

8. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.

Authors: D C Schwartz; C R Cantor
Journal: Cell Date: 1984-05 Impact factor: 41.582

9. Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome.

Authors: K E Davies; P L Pearson; P S Harper; J M Murray; T O'Brien; M Sarfarazi; R Williamson
Journal: Nucleic Acids Res Date: 1983-04-25 Impact factor: 16.971

10. Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry.

Authors: K E Davies; B D Young; R G Elles; M E Hill; R Williamson
Journal: Nature Date: 1981-10-01 Impact factor: 49.962

24 in total

1. Adrenoleucodystrophy: a molecular genetic study in five families.

Authors: R G Del Mastro; S Bundey; M W Kilpatrick
Journal: J Med Genet Date: 1990-11 Impact factor: 6.318

2. Unusual X chromosome inactivation in a mentally retarded girl with an interstitial deletion Xq27: implications for the fragile X syndrome.

Authors: M Schmidt; A Certoma; D Du Sart; P Kalitsis; M Leversha; K Fowler; L Sheffield; I Jack; D M Danks
Journal: Hum Genet Date: 1990-03 Impact factor: 4.132

Review 3. The fragile X: progress toward solving the puzzle.

Authors: W T Brown
Journal: Am J Hum Genet Date: 1990-08 Impact factor: 11.025

4. Physical and genetic mapping of polymorphic loci in Xq28 (DXS15, DXS52, and DXS134): analysis of a cosmid clone and a yeast artificial chromosome.

Authors: R Feil; G Palmieri; M d'Urso; R Heilig; I Oberlé; J L Mandel
Journal: Am J Hum Genet Date: 1990-04 Impact factor: 11.025

5. Dissociation between mental retardation and fragile site expression in a family with fragile X-linked mental retardation.

Authors: M A Voelckel; M G Mattei; C N'Guyen; N Philip; F Birg; J F Mattei
Journal: Hum Genet Date: 1988-12 Impact factor: 4.132