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Literature DB >> 3162079

Mitochondrial resistance to miconazole in Saccharomyces cerevisiae.

Abstract

One mutant of mitochondrial origin resistant to miconazole has been isolated and characterized in S. cerevisiae. The mutation is linked to the locus oli1, the structural gene for subunit 9 of ATPase on mitochondrial DNA. Miconazole inhibited the mitochondrial ATPase of the wild type while the enzyme of the resistant mutant was insensitive to this effect. Levels of ATP decreased to one-third of the control in the wild type in the presence of miconazole, while they were unaffected in the mutant.

Entities: Chemical Species

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Year: 1985 PMID： 3162079 DOI： 10.1007/bf00330764

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

14 in total

1. An outer metabolic region of the yeast cell.

Authors: E J CONWAY; M DOWNEY
Journal: Biochem J Date: 1950-09 Impact factor: 3.857

2. Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans.

Authors: H van den Bossche; G Willemsens; W Cools; W F Lauwers; L Le Jeune
Journal: Chem Biol Interact Date: 1978-04 Impact factor: 5.192

3. Mitochondrial genetics. V. Multifactorial mitochondrial crosses involving a mutation conferring paromomycin-resistance in Saccharomyces cerevisiae.

Authors: K Wolf; B Dujon; P P Slonimski
Journal: Mol Gen Genet Date: 1973-09-05

4. Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles.

Authors: H Van den Bossche; G Willemsens; W Cools; P Marichal; W Lauwers
Journal: Biochem Soc Trans Date: 1983-12 Impact factor: 5.407

5. Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein.

Authors: S M Read; D H Northcote
Journal: Anal Biochem Date: 1981-09-01 Impact factor: 3.365

6. Cytoduction: a tool for mitochondrial genetic studies in yeast. Utilization of the nuclear-fusion mutation kar 1-1 for transfer of drug r and mit genomes in Saccharomyces cerevisiae.

Authors: W E Lancashire; J R Mattoon
Journal: Mol Gen Genet Date: 1979-03-05

Mitochondrial resistance to miconazole in Saccharomyces cerevisiae.

1. An outer metabolic region of the yeast cell.

2. Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans.

3. Mitochondrial genetics. V. Multifactorial mitochondrial crosses involving a mutation conferring paromomycin-resistance in Saccharomyces cerevisiae.

4. Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles.

5. Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein.

6. Cytoduction: a tool for mitochondrial genetic studies in yeast. Utilization of the nuclear-fusion mutation kar 1-1 for transfer of drug r and mit genomes in Saccharomyces cerevisiae.

7. Mode of action of miconazole on yeasts: inhibition of the mitochondrial ATPase.

8. Energy metabolism of Saccharomyces cerevisiae discrepancy between ATP balance and known metabolic functions.

9. Studies on the genetic regulation of cytochrome P-450 production in Saccharomyces cerevisiae.

10. Characterization of the plasma membrane ATPase of Saccharomyces cerevisiae.

Review 1. Drug resistance in human pathogenic fungi.

2. Effect of miconazole on growth and aflatoxin production by Aspergillus parasiticus.