Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.

Literature DB >> 31563041

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.

Abstract

The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated APOBEC3 expression in cancer cells, has raised the possibility that these enzymes contribute to oncogenesis. Genome deamination by APOBEC3 enzymes also elicits DNA damage response signaling and presents therapeutic vulnerabilities for cancer cells. Here, we discuss implications of APOBEC3 activity in cancer and the potential to exploit their mutagenic activity for targeted cancer therapies.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: APOBEC3; Cytosine deaminase; DNA damage response; Mutational patterns; Synthetic lethality

Mesh：

Substances：

Year: 2019 PMID： 31563041 PMCID： PMC6876854 DOI： 10.1016/j.dnarep.2019.102700

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

114 in total

1. Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.

Authors: Rodolphe Suspène; Marie-Ming Aynaud; Stefanie Koch; David Pasdeloup; Marc Labetoulle; Barbara Gaertner; Jean-Pierre Vartanian; Andreas Meyerhans; Simon Wain-Hobson
Journal: J Virol Date: 2011-06-01 Impact factor: 5.103

2. DNA deamination mediates innate immunity to retroviral infection.

Authors: Reuben S Harris; Kate N Bishop; Ann M Sheehy; Heather M Craig; Svend K Petersen-Mahrt; Ian N Watt; Michael S Neuberger; Michael H Malim
Journal: Cell Date: 2003-06-13 Impact factor: 41.582

3. Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome.

Authors: Qin Yu; Renate König; Satish Pillai; Kristopher Chiles; Mary Kearney; Sarah Palmer; Douglas Richman; John M Coffin; Nathaniel R Landau
Journal: Nat Struct Mol Biol Date: 2004-04-18 Impact factor: 15.369

4. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

Authors: Steven A Roberts; Michael S Lawrence; Leszek J Klimczak; Sara A Grimm; David Fargo; Petar Stojanov; Adam Kiezun; Gregory V Kryukov; Scott L Carter; Gordon Saksena; Shawn Harris; Ruchir R Shah; Michael A Resnick; Gad Getz; Dmitry A Gordenin
Journal: Nat Genet Date: 2013-07-14 Impact factor: 38.330

5. Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.

Authors: Richard N McLaughlin; Jacob T Gable; Cristina J Wittkopp; Michael Emerman; Harmit S Malik
Journal: Mol Biol Evol Date: 2016-04-06 Impact factor: 16.240

6. Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.

Authors: Rodolphe Suspène; Marie-Ming Aynaud; Denise Guétard; Michel Henry; Grace Eckhoff; Agnès Marchio; Pascal Pineau; Anne Dejean; Jean-Pierre Vartanian; Simon Wain-Hobson
Journal: Proc Natl Acad Sci U S A Date: 2011-03-02 Impact factor: 11.205

7. Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.

Authors: Candace D Middlebrooks; A Rouf Banday; Konichi Matsuda; Krizia-Ivana Udquim; Olusegun O Onabajo; Ashley Paquin; Jonine D Figueroa; Bin Zhu; Stella Koutros; Michiaki Kubo; Taro Shuin; Neal D Freedman; Manolis Kogevinas; Nuria Malats; Stephen J Chanock; Montserrat Garcia-Closas; Debra T Silverman; Nathaniel Rothman; Ludmila Prokunina-Olsson
Journal: Nat Genet Date: 2016-09-19 Impact factor: 38.330

8. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

Authors: Ann M Sheehy; Nathan C Gaddis; Jonathan D Choi; Michael H Malim
Journal: Nature Date: 2002-07-14 Impact factor: 49.962

9. APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.

Authors: Stephen Henderson; Ankur Chakravarthy; Xiaoping Su; Chris Boshoff; Tim Robert Fenton
Journal: Cell Rep Date: 2014-06-05 Impact factor: 9.423

10. Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.

Authors: Serena Nik-Zainal; David C Wedge; Ludmil B Alexandrov; Mia Petljak; Adam P Butler; Niccolo Bolli; Helen R Davies; Stian Knappskog; Sancha Martin; Elli Papaemmanuil; Manasa Ramakrishna; Adam Shlien; Ingrid Simonic; Yali Xue; Chris Tyler-Smith; Peter J Campbell; Michael R Stratton
Journal: Nat Genet Date: 2014-04-13 Impact factor: 38.330

23 in total

1. Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes.

Authors: Anna Julia Wiecek; Daniel Hadar Jacobson; Wojciech Lason; Maria Secrier
Journal: Front Cell Dev Biol Date: 2021-07-09

2. Controllable genome editing with split-engineered base editors.

Authors: Kiara N Berríos; Niklaus H Evitt; Rachel A DeWeerd; Diqiu Ren; Meiqi Luo; Aleksia Barka; Tong Wang; Caroline R Bartman; Yemin Lan; Abby M Green; Junwei Shi; Rahul M Kohli
Journal: Nat Chem Biol Date: 2021-10-18 Impact factor: 15.040

3. Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.

Authors: Keith C K Lau; Shivali S Joshi; Douglas J Mahoney; Andrew L Mason; Guido van Marle; Carla Osiowy; Carla S Coffin
Journal: Front Microbiol Date: 2020-07-14 Impact factor: 5.640

Review 4. Molecular origins of APOBEC-associated mutations in cancer.

Authors: Mia Petljak; John Maciejowski
Journal: DNA Repair (Amst) Date: 2020-07-06

Review 5. Interactions of APOBEC3s with DNA and RNA.

Authors: Atanu Maiti; Shurong Hou; Celia A Schiffer; Hiroshi Matsuo
Journal: Curr Opin Struct Biol Date: 2021-01-22 Impact factor: 6.809

6. Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection.

Authors: Maxwell Shapiro; Laurie T Krug; Thomas MacCarthy
Journal: PLoS Pathog Date: 2021-04-30 Impact factor: 6.823