| Literature DB >> 31548407 |
Cristian Tomasetti1,2,3, Justin Poling4, Nicholas J Roberts2,5, Nyall R London6, Meredith E Pittman7, Michael C Haffner2,8, Anthony Rizzo8, Alex Baras8, Baktiar Karim9, Antonio Kim2, Christopher M Heaphy2,8, Alan K Meeker2,8, Ralph H Hruban2,5,8,10,11, Christine A Iacobuzio-Donahue12, Bert Vogelstein13,10,11.
Abstract
A new evaluation of previously published data suggested to us that the accumulation of mutations might slow, rather than increase, as individuals age. To explain this unexpected finding, we hypothesized that normal stem cell division rates might decrease as we age. To test this hypothesis, we evaluated cell division rates in the epithelium of human colonic, duodenal, esophageal, and posterior ethmoid sinonasal tissues. In all 4 tissues, there was a significant decrease in cell division rates with age. In contrast, cell division rates did not decrease in the colon of aged mice, and only small decreases were observed in their small intestine or esophagus. These results have important implications for understanding the relationship between normal stem cells, aging, and cancer. Moreover, they provide a plausible explanation for the enigmatic age-dependent deceleration in cancer incidence in very old humans but not in mice.Entities:
Keywords: aging; cancer; cell division; mutation rate
Year: 2019 PMID： 31548407 PMCID： PMC6789572 DOI： 10.1073/pnas.1905722116
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205